New drug cocktail shows promise against Drug-Resistant TB
NCT ID NCT02333799
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested a combination of three drugs—bedaquiline, pretomanid, and linezolid—in 109 people with extensively drug-resistant TB (XDR-TB) or multi-drug resistant TB (MDR-TB) that didn't respond to other treatments. Participants took the drugs for 6 to 9 months. The goal was to see if the combo could clear the infection and prevent it from coming back. Results from this completed phase 3 trial help show whether this shorter, all-oral regimen is a safe and effective option for tough TB cases.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of three drugs: bedaquiline, pretomanid (PA-824), and linezolid
- What this could lead to
- If successful, this could provide a shorter, more effective treatment option for people with highly drug-resistant tuberculosis, potentially replacing longer and more toxic regimens.
- What could go wrong
- This is a completed phase 3 trial with 109 participants, so results are more reliable than earlier studies. However, the combination may still cause side effects like nerve damage or bone marrow suppression from linezolid, and it may not work for all TB strains.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PULMONARY TUBERCULOSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
King DinuZulu Hospital Complex
Sydenham, Durban, 4001, South Africa
-
Sizwe Tropical Disease Hospital
Sandringham, Johannesburg, 2131, South Africa
-
Task Applied Science - Brooklyn Chest Hospital
Ysterplaat, Cape Town, 7405, South Africa
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new patient cohort unlock the secrets of TB treatment success?
- Shorter TB treatment: a 4-Month regimen put to the test
- Lung damage after TB: a new study tests whether rehabilitation can restore breathing and quality of life
- Can a more powerful antibiotic clear TB faster? a trial puts rifapentine to the test.
- Could a simple screening strategy uncover hidden TB in COPD patients?
- Talking it out: could counseling be the key to beating TB?