Mycobacterial infectious disease

This study tests whether a higher dose of the drug rifampicin can safely shorten tuberculosis treatment for children aged 3 months to 10 years. About 230 children with drug-susceptible TB will receive either the standard or a higher rifampicin dose, with treatment duration adjust…

This study tests whether tuberculosis (TB) treatment can be tailored to each person's risk of a poor outcome. About 900 adults with drug-sensitive TB will be grouped as lower-risk or higher-risk. Lower-risk participants may get a shorter treatment course, while higher-risk partic…

This trial is testing a new vaccine called rBCG-N-RSV, which is based on the BCG vaccine (used for tuberculosis) but modified to also target respiratory syncytial virus (RSV). The study involves 200 adults over 60 years old, who will receive either this new vaccine or the standar…

This study tests an experimental tuberculosis vaccine called Lipovaxin in healthy adults aged 18 to 40 in Indonesia. The vaccine is given as two shots, 28 days apart, and compared to a placebo. The main goals are to check if the vaccine is safe and whether it triggers an immune r…

This study tests an experimental vaccine called ID93 + GLA-SE in 1500 people with drug-susceptible pulmonary TB. Participants receive the vaccine or a placebo alongside their regular TB treatment. Researchers want to see if the vaccine can improve immune responses and reduce poor…

Many people who recover from tuberculosis are left with long-term lung damage, known as post-tuberculosis lung disease (PTLD), which can cause breathing problems and reduce quality of life. This study follows 760 participants—including people with active TB, those with establishe…

This trial tests whether a package of support from a community health worker can help adults hospitalized with advanced HIV in Lusaka, Zambia, stay in care and survive longer. Participants are randomly assigned to receive the ARC intervention or standard care and are followed for…

This study tests whether an 8-week supervised pulmonary rehabilitation program can improve breathing, exercise capacity, and quality of life in adults with persistent lung problems after completing tuberculosis treatment. Participants are randomly assigned to either the rehab pro…

This study tests whether structured psychosocial counseling can improve treatment adherence in adults newly diagnosed with pulmonary tuberculosis. Participants in 10 primary health centers in Indonesia will either receive standard care or standard care plus counseling sessions. T…

This phase 3 trial tests whether a 6-month combination of five drugs (bedaquiline, delamanid, delpazolid, levofloxacin, and pyrazinamide) works as well as standard treatment for rifampicin-resistant tuberculosis in adults and adolescents aged 15 and older in South Africa. The stu…

This study looks at whether shorter, rifapentine-based treatments for tuberculosis and latent TB are safe and effective in real-world settings in Kazakhstan. It will follow 350 adults, including those with HIV, comparing a 4-month regimen to the standard 6-month one for active TB…

This study will compare two different HIV medication combinations in 60 people who also have active tuberculosis. Participants will receive either a newer drug (Ainuovirine) or a standard one (Efavirenz), along with their TB meds. The goal is to see which regimen better suppresse…

This phase 3 trial tests whether adding a steroid (hydrocortisone) and a stronger mix of antibiotics to standard care can improve survival in HIV patients with sepsis in sub-Saharan Africa. The study will enroll 344 adults and measure how many are alive after 28 days. It aims to …

This study tests whether a shorter, 5-month combination of TB drugs works as well as the standard 6-month treatment for people with both HIV and drug-susceptible tuberculosis. It involves 148 participants with very weak immune systems (CD4 count under 100). The goal is to see if …

This trial tests whether adding a fluoroquinolone antibiotic to the standard three-drug treatment helps HIV patients with a serious bacterial infection called disseminated MAC. About 124 adults will be randomly assigned to get either the standard therapy or the four-drug combo fo…

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…

This study tests whether adding nurse-led educational sessions helps people with tuberculosis stick to their treatment plan. About 40 adults recently diagnosed with TB will receive extra guidance from nurses. The goal is to see if this support improves treatment completion and re…

This study tests a new 6-month treatment called BPaLM for people with multidrug-resistant tuberculosis (MDR-TB). The goal is to see if it works as well as the current 18+ month regimen. About 55 adults in France will receive the shorter treatment, and their outcomes will be compa…

This trial tests a new combination of antibiotics (called Arm D) against standard treatments for a rare lung infection caused by Mycobacterium abscessus. About 300 people with or without cystic fibrosis will take part. The goal is to see if the new combo clears the infection bett…

This Phase II trial tests whether an AI-optimized combination of pyrazinamide and hydroxychloroquine works better than the standard four-drug RIPE regimen for newly diagnosed drug-sensitive pulmonary tuberculosis. Two hundred adults will receive either the new AI-personalized tre…

This study tests a new two-drug combination (Alpibectir and Ethionamide) added to standard treatment for tuberculosis meningitis, a serious brain infection. About 64 adults newly diagnosed with the condition will receive the drugs to see how well they reach the brain and how safe…

This early study tests a special cocktail of viruses (phages) designed to attack a drug-resistant bacterium causing chronic lung infection. Only one person will receive the treatment alongside their usual antibiotics. The goal is to see if it's safe and can reduce the amount of b…

This study tests whether adding acetohydroxamic acid (AHA) to a short-course antibiotic regimen can safely and effectively treat multidrug-resistant tuberculosis (MDR-TB). About 120 adults with confirmed MDR-TB will receive either AHA or a placebo alongside standard drugs. The go…

This study tests whether placing one-way valves in the lungs can shrink cavities caused by drug-resistant tuberculosis (TB) or nontuberculous mycobacteria (NTM) infections. The valves block airflow into the cavity, creating a low-oxygen environment that may slow or stop bacterial…

This study will test two ways to find TB in pregnant women with HIV: using symptoms or a blood test. It will also compare starting TB prevention medicine right away versus after giving birth. The goal is to reduce harm to mothers and babies. About 1,500 pregnant women in Uganda w…

This phase 3 trial tests a 9-month, all-oral combination of four drugs (BLMZ) for people aged 12 and older with rifampicin-resistant tuberculosis. The goal is to see if this shorter regimen leads to a cure without the need for injections. Participants take the pills daily or week…

This study tests whether using a chat-based mobile app (Zalo) can help people follow through with recommended tests after an abnormal chest X-ray read by AI. About 2,692 adults in Vietnam at risk for lung cancer or TB will be randomly assigned to receive either standard results o…

This study tests whether a 6-month combination of four drugs (bedaquiline, delamanid, linezolid, and levofloxacin) works as well as the standard longer treatment for drug-resistant tuberculosis. Fifty-two adults in Hubei, China will be randomly assigned to either the short or sta…

This study tests a 6-month treatment regimen containing pretomanid for people with drug-resistant tuberculosis who also have type 2 diabetes. Researchers will compare how well the treatment works and how safe it is in diabetic patients versus non-diabetic patients. The goal is to…

This study looks at people who have TB-like changes on chest X-rays but negative sputum tests. It compares different treatment lengths (8 to 24 weeks) versus close monitoring without immediate treatment. The goal is to find the shortest effective treatment and understand who real…

This study looks at whether two simple calculations, called Cancer Ratio and Cancer Ratio Plus, can help doctors tell the difference between fluid around the lungs caused by cancer and fluid caused by tuberculosis. These calculations use results from routine blood and fluid tests…

This study tests a community-based screening strategy for tuberculosis (TB) in migrant communities in New York City. A mobile van offers digital chest X-rays with AI interpretation, along with TB symptom checks, blood tests for latent TB, and HIV testing. The goal is to see wheth…

This study tests whether an AI-powered digital stethoscope can help health workers more accurately diagnose pneumonia in children aged 2 months to 5 years. 350 children with cough or breathing difficulty will be randomly assigned to standard care or care plus the AI stethoscope. …

This trial tests a new DNA test that reads drug resistance directly from sputum samples in people with multidrug-resistant tuberculosis (MDR-TB). The goal is to see if this test helps doctors prescribe at least five effective drugs within 14 days of diagnosis, compared to current…

This large study in five countries will test new, portable diagnostic tools for tuberculosis (TB) that use tongue swabs and AI-assisted chest X-rays. The goal is to see if these faster, easier tests can find more TB cases, especially in people who have no symptoms or can't produc…

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This trial tests a new biopsy method called EBUS-TBMC against the standard needle approach for diagnosing tuberculosis in chest lymph nodes. About 108 adults with suspected TB will undergo both procedures in one session to see which yields better tissue samples. The goal is to im…

This study will test a new, portable device that can detect tuberculosis (TB) in about 15-35 minutes using a simple tongue or sputum swab. It aims to enroll 60,000 people in Bangladesh, Cameroon, and Nigeria who are screened in community settings. The goal is to see if this rapid…

This study tests whether new, easier-to-use diagnostic tests for tuberculosis (TB) can help find more cases in Indonesia. About 40,000 people with TB symptoms will take part. Some clinics will use the new tests, while others will use standard methods. The goal is to see if the ne…

This study tests a new liquid biopsy that measures TB DNA in fluid from around the lungs to diagnose tuberculous pleuritis, a common form of TB. Current methods often require invasive tissue biopsies or have low accuracy. The trial will enroll 350 adults with new-onset pleural ef…

This study aims to find better ways to diagnose tuberculosis (TB) in children and young teens. It will test new tools like computer-aided chest X-ray reading and non-sputum samples (e.g., stool or urine) in Bangladesh, Cameroon, Kenya, and Vietnam. About 7,920 participants aged 1…

This study tests a new blood test that looks for TB DNA in the blood. It aims to see if it works as well as a bronchoscopy (a scope down the throat) to diagnose lung tuberculosis. 600 adults who need a bronchoscopy will give a blood sample for comparison. If successful, patients …

This trial investigates whether annual re-screening for tuberculosis infection using a blood test (IGRA) can prevent active TB in people with autoimmune rheumatic diseases who are taking biologic or immunosuppressive medications. Participants who initially test negative for TB ar…

This study explores whether community health workers can use a new skin test, with or without AI help, to test close contacts of TB patients at home instead of at a clinic. The goal is to make it easier for people, especially children and families in Tajikistan and Tanzania, to g…

This study tests a simpler way to give TB preventive therapy to household contacts of TB patients and people living with HIV. Instead of monthly clinic visits, some participants get the full course of pills at once in their community. Researchers want to see if this approach help…

This study tests a 28-day daily combination of two drugs, rifapentine and isoniazid, to prevent tuberculosis (TB) in children under 13. About 144 children, some with HIV and some without, will join to find the right dose and check for side effects. The goal is to see if this shor…

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This study compares three different ways to screen for and prevent tuberculosis (TB) in prisons in Paraguay. About 4,500 inmates will be tested and followed for 18 months to see which strategy best reduces new TB cases and infections. The goal is to find a safe, effective, and af…

This study tests whether having health workers visit homes can improve tuberculosis (TB) prevention for children under 15 in southern Ethiopia. About 1,300 children will be split into two groups: one gets home-based care, the other standard clinic care. The goal is to see if more…

This study tests whether online mindfulness, digital cognitive behavioral therapy, and an interactive chatbot can reduce stigma and improve mental health in people with tuberculosis. About 496 adults with active TB will be randomly assigned to receive these digital tools alongsid…

This study tests whether a supervised exercise and education program (pulmonary rehabilitation) can help people with long-term lung diseases like COPD, asthma, and post-TB lung damage in Nigeria, South Africa, and Cameroon. Researchers will enroll 90 patients to see if the progra…

This early-stage study looks at how a common tuberculosis drug, rifampin, affects levels of a new HIV prevention medicine called MK-8527. Fourteen adults with latent TB (no active symptoms) will take MK-8527 with and without rifampin. The goal is to see if the two drugs can be us…

This study aims to better understand tuberculosis (TB) across its entire spectrum—from early, symptom-free infection to active disease and after treatment. Researchers will recruit TB patients and their close contacts to analyze immune responses and identify biomarkers that could…

This trial evaluates an active case-finding strategy to detect pulmonary tuberculosis (TB) among people with chronic obstructive pulmonary disease (COPD) in primary care clinics in Henan, China. The strategy uses computer-aided diagnosis and a rapid TB test during routine COPD vi…

This study works with African and South Asian immigrants to design a tuberculosis (TB) screening program that fits their needs. Researchers will hold workshops with immigrants, community leaders, and doctors to identify barriers and create a screening pathway. Then, they will tes…

This study collects long-term data from tuberculosis patients across Europe to better understand the disease and its treatment. Researchers track risk factors, diagnostic details, side effects, and outcomes for both drug-sensitive and drug-resistant TB. The goal is to identify wh…

This study will use artificial intelligence to analyze data from over 31,000 tuberculosis patients. The goal is to create a system that helps doctors decide which patients can be cured with a short treatment course and which need longer therapy. The AI will be tested to see if it…

This study looks back at records of over 1,000 new hospital workers in Nice, France, who were tested for latent (hidden) tuberculosis infection as part of their hiring process. The goal is to see how many test positive, what factors increase the risk, and whether the screening le…

This study looks at how people diagnosed with tuberculosis (TB) in rural and coastal areas of Southwest England experience stigma. Researchers will interview 20 patients to understand how stigma affects their lives and access to care. The goal is to develop better ways to support…

This study aims to create a database of 686 adults with suspected or confirmed tuberculosis at an Italian hospital. Researchers will analyze patient data to build a risk score that helps doctors quickly decide who needs isolation and who can be ruled out. The goal is to improve d…

This study will track 220 adults being treated for tuberculosis (TB) or latent TB with the drug isoniazid. Researchers want to see how often the drug causes liver injury and what factors make it more likely. They will also look at how doctors manage this side effect in real-world…

This study looks back at the medical records of 130 people diagnosed with Hansen's disease (leprosy) in Costa Rica between 2018 and 2025. The goal is to describe the patients, how the disease was diagnosed, what treatments were used, and what complications occurred. No new treatm…

This study will test better ways to screen for tuberculosis (TB) in pregnant and postpartum women in Guinea-Bissau. Researchers will use a symptom checklist, stool tests, and AI-powered chest X-rays to find more TB cases. The goal is to improve health for mothers and babies and g…

This study looks at how five common tuberculosis drugs move into breast milk after a single dose. Sixty healthy breastfeeding women in Indonesia will each receive one drug, and researchers will measure drug levels in their blood and milk. The goal is to gather safety data so that…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This study looks at a lung infection called NTM lung disease in South China. Researchers will review medical records of about 1,500 patients and collect samples from around 100 current patients to learn how the immune system reacts. The goal is to help doctors diagnose and manage…

This study looks at how the body's immune response and nutrition are linked to the progression of nontuberculous mycobacterial pulmonary disease (NTM-PD), a chronic lung infection. Researchers will analyze immune cells from the lungs and blood of 50 adults with confirmed or suspe…

This study will test a new way to care for people in Ghana who have both a neglected tropical skin disease (like leprosy or Buruli ulcer) and mental health challenges like depression or anxiety. Researchers will work with 200 affected adults and local health workers to create a G…

This study will test 200 adults on regular hemodialysis at Sohag University Hospital for latent tuberculosis infection (LTBI) using a simple skin test. The goal is to find out how many dialysis patients carry the bacteria without symptoms, so doctors can better prevent active TB …

This study will test 250 people with tuberculosis (TB) to see how common drug resistance is. Using special rapid tests called GeneXpert, researchers will look for resistance to key TB drugs like Rifampicin. They also want to find out if things like diabetes or drug addiction make…

This study in Kenya will test whether a new blood test, called PATHFAST TB LAM ag, can better track how well tuberculosis (TB) treatment is working. Researchers will follow 300 adults with TB, collecting samples regularly during their 6-month treatment. The goal is to see if chan…