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Personalized TB treatment could shorten recovery time

NCT ID NCT07595042

Not yet recruiting ⭐️ CURE ⭐️ Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether tuberculosis (TB) treatment can be tailored to each person's risk of a poor outcome. About 900 adults with drug-sensitive TB will be grouped as lower-risk or higher-risk. Lower-risk participants may get a shorter treatment course, while higher-risk participants may receive a stronger drug combination. The goal is to see if personalized treatment can improve cure rates and reduce side effects.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TUBERCULOSIS

Contacts and locations

Locations

  • Barranco CRS (Site #: 11301)

    Lima, Peru

  • Blantyre CRS (Site #: 30301)

    Blantyre, Malawi

  • Byramjee Jeejeebhoy Government Medical College (BJGMC) CRS (Site #: 31441)

    Pune, Maharashtra, 411001, India

  • Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales CRS (CITBM) - Unidad de Ensayos Clínicos (UNIDEC) (Site # 31970)

    Callao, Peru

  • Chiang Mai University HIV Treatment (CMU HIV Treatment) CRS (Site #: 31784)

    Chiang Mai, 50200, Thailand

  • Chiangrai Prachanukroh Hospital NICHD CRS (Site # 5116)

    Chiang Rai, Thailand

  • Fundacion Huesped CRS (Site # 31957)

    Buenos Aires, Argentina

  • GHESKIO Institute of Infectious Diseases and Reproductive Health (GHESKIO - IMIS) CRS (Site #: 31730)

    Port-au-Prince, HT-6110, Haiti

  • Gaborone CRS (Site #: 12701)

    Gaborone, Botswana

  • Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS (Site #: 12101)

    Rio de Janeiro, 21040-360, Brazil

  • Instituto de Pesquisas em AIDS do Rio Grande do Sul - IPARGS CRS (Site # 12201)

    Rio Grande, Brazil

  • Joint Clinical Research Centre (JCRC)/Kampala Clinical Research Site (Site #: 12401)

    Kampala, 10005, Uganda

  • Kenya Medical Research Institute/Walter Reed Project Clinical Research Center (KEMRI/WRP) CRS (Site #: 12501)

    Kericho, Rift Valley, 20200, Kenya

  • Kilimanjaro Christian Medical Centre (KCMC) (Site # 5118)

    Moshi, Tanzania

  • Les Centres GHESKIO Clinical Research Site (GHESKIO-INLR) CRS (Site #: 30022)

    Port-au-Prince, HT-6110, Haiti

  • MU-JHU Research Collaboration (MUJHU CARE LTD) CRS (Site # 30293)

    Kampala, Uganda

  • Malawi CRS (Site #: 12001)

    Lilongwe, Central Region, Malawi

  • Milton Park CRS (Site #: 30313)

    Harare, 263663, Zimbabwe

  • Moi University Clinical Research Center (MUCRC) CRS (Site #: 12601)

    Eldoret, Rift Valley, 30100, Kenya

  • Molepolole CRS (Site # 12702)

    Gaborone, Botswana

  • National Lung Hospital (Site #: 32483)

    Hanoi, 100000, Vietnam

  • Nutrición-Mexico CRS (Site #: 32078)

    Mexico City, 14000, Mexico

  • San Miguel CRS (Site # 11302)

    Lima, Peru

  • Siriraj Hospital, Mahidol University NICHD CRS (Site # 5115)

    Bangkok, Thailand

  • Socios en Salud Sucursal Peru CRS (Site # 31985)

    Lima, Peru

  • TB HIV Innovations and Clinical Research Foundation Corp. (Site #: 31981)

    Dasmariñas, Cavite, 4114, Philippines

  • Thai Red Cross AIDS Research Centre (TRC-ARC) CRS (Site #: 31802)

    Pathum Wan, Bangkok, 10330, Thailand

  • Vietnam-University of Sydney CRS (Site # 32495)

    Sydney, Australia

  • YRG CARE CRS (Site # 32075)

    Chennai, India

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