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Scientists investigate mysterious lung infection in south china

NCT ID NCT07377864

Knowledge-focused Sponsor: Eighth Affiliated Hospital, Sun Yat-sen University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at a lung infection called NTM lung disease in South China. Researchers will review medical records of about 1,500 patients and collect samples from around 100 current patients to learn how the immune system reacts. The goal is to help doctors diagnose and manage the disease better. No new drugs or treatments are being tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,500 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study population comprises patients diagnosed with nontuberculous mycobacterial infection in South China. It includes two nested cohorts: (1) a large multicenter retrospective cohort of approximately 1,500 patients identified from hospital records between 2015 and 2025, from whom clinical and epidemiological data will be extracted; and (2) a prospective sub-cohort of about 106 patients consecutively enrolled from the aforementioned group, who will provide additional biospecimens (peripheral blood and bronchoalveolar lavage fluid) for mechanistic laboratory investigations.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:1. (Both Cohorts): * Patients diagnosed with nontuberculous mycobacterial according to standard guidelines. * Aged 18 years or older. * Available medical records covering the period from 2015 to 2025 (for the retrospective cohort). 2\. (Prospective Sub-cohort Additional): * Willing and able to provide written informed consent for biospecimen collection. * Clinically stable and suitable for undergoing research bronchoalveolar lavage (BAL) procedure, as judged by the investigator. Exclusion Criteria: 1. (Both Cohorts): * Active tuberculosis or other dominant pulmonary infections. * Incomplete medical records that preclude adequate data extraction (for retrospective analysis). 2\. (Prospective Sub-cohort Additional): * Contraindications to bronchoscopy or BAL procedure. * Pregnancy or lactation. * Any condition that, in the opinion of the investigator, would compromise patient safety or data integrity.

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Conditions

The condition(s) this trial relates to.

Mycobacterium avium complex disease pulmonary non-tuberculous mycobacterial infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mycobacterium avium complex (MAC) Nontuberculous mycobacterial lung disease

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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