Infectious disease

This expanded access program lets doctors in Texas give banked, partially matched virus-specific T cells to children under 18 who have persistent or recurring EBV, CMV, adenovirus, or BK virus infections after an allogeneic stem cell transplant or CAR T therapy. The cells come fr…

Researchers are testing whether a combination of cipargamin and KLU156 (ganaplacide plus lumefantrine) can cure uncomplicated Plasmodium falciparum malaria in children aged 2 to under 12. The trial compares this oral regimen with standard Coartem treatment. The main goal is to se…

This study tests a new two-drug combination (ASC22 and Peg-IFNa) to see if it can functionally cure chronic hepatitis B. About 150 adults with low virus levels will receive the treatment. The goal is to raise the cure rate above 50% without needing lifelong medication.

This pilot study is testing whether a 4-week course of two antiviral drugs—sofosbuvir plus glecaprevir/pibrentasvir—can cure chronic hepatitis C in people who have not been treated before and have only mild liver scarring. Participants who relapse after the short treatment will r…

This trial tests different doses of tafenoquine, a single-dose drug, to see if it can effectively cure Plasmodium vivax malaria by targeting dormant liver stages. The study involves 820 people in Southeast Asia with confirmed vivax malaria. Researchers aim to find a dose that pre…

This trial compares different surgical and antibiotic approaches to treat infections in artificial hip and knee joints. It tests whether cleaning the joint while keeping the implant in place (DAIR) or replacing the joint entirely leads to better cure rates. It also examines wheth…

This large phase 3 trial compares an investigational mRNA flu vaccine with a licensed flu vaccine in adults aged 65 and older. Each participant receives a single injection and is followed through the flu season. Researchers measure how well the mRNA vaccine prevents laboratory-co…

This study tests an experimental flu vaccine called BPL-1357, given as a shot or nasal spray, to see if it is safe and can protect against multiple flu types. About 129 healthy adults aged 18-55 will receive the vaccine or a placebo, then be exposed to a flu virus in a controlled…

This early-stage trial is testing a new COVID-19 booster vaccine called OCU500, which is given as a nasal spray or inhaled mist instead of a shot. The study involves 80 healthy adults aged 18-64 who have already been vaccinated against COVID-19. Researchers are checking if the va…

This early-stage trial is testing a new HIV vaccine booster called VRIPRO, given with an immune-boosting adjuvant, in 40 healthy adults aged 18-60 who previously received an HIV vaccine in the HVTN 706 study. Participants will get three shots over 24 weeks. The main goals are to …

This early-stage study is testing two new vaccines (V350A and V350B) designed to prevent diseases caused by the Epstein-Barr virus (EBV), which can cause infectious mononucleosis and is linked to certain cancers and multiple sclerosis. The study will enroll 250 healthy adults and…

Researchers are testing a single injection vaccine designed to protect adults 60 and older from two respiratory viruses: RSV and HMPV. The trial plans to enroll about 8,000 participants who will randomly receive either the vaccine or a placebo. Scientists will track who develops …

This phase 2 trial tests a CMV vaccine (CMV-MVA Triplex) given before a liver transplant to see if it reduces the need for antiviral drugs after surgery. The study enrolls 416 CMV-negative adults awaiting a liver transplant from a CMV-positive donor. Participants receive two vacc…

This trial is testing a new vaccine called rBCG-N-RSV, which is based on the BCG vaccine (used for tuberculosis) but modified to also target respiratory syncytial virus (RSV). The study involves 200 adults over 60 years old, who will receive either this new vaccine or the standar…

This early-stage trial tests an experimental flu vaccine called FluMos-v2, with or without an adjuvant (ALFQ), in 45 healthy adults aged 18-50. Participants receive two shots four months apart and are followed for 15 months. The goal is to check safety and how well the vaccine tr…

This study tests a new pneumococcal vaccine in about 2400 healthy infants starting at 2 months old. The goal is to see if the new vaccine is as safe as the current vaccine, Prevnar 20, and if it can protect against more types of bacteria that cause pneumonia, meningitis, and ear …

This study tests a new chickenpox vaccine called NBP608 in about 780 children aged 1 to 12 years. The vaccine is compared to licensed vaccines to see how well it triggers immunity and if it is safe. Children receive one or two shots, and researchers monitor their immune response …

This trial is testing an experimental vaccine against H5N8, a type of bird flu, in healthy adults aged 18 and older. The vaccine is made using eggs and is given as two shots, with or without an adjuvant—a substance that may boost the immune response. The study aims to see if the …

Researchers are testing an experimental mRNA vaccine called ABO1108 to see whether it can prevent herpes zoster, the painful rash also known as shingles. The trial enrolls adults aged 40 and older, including people whose long-term conditions are stable. Participants receive two i…

This early-stage trial will test two experimental mRNA vaccines designed to teach the immune system to make antibodies that target HIV. About 42 adults with well-controlled HIV will receive the vaccines and then temporarily pause their regular HIV medication under close monitorin…

Researchers are testing an experimental vaccine called INT101 to see if it is safe and can trigger an immune response against norovirus. The trial enrolls about 30 healthy adults aged 19 to 48. Participants receive either a low dose, a high dose, or a placebo as three intramuscul…

This study tests a new dengue vaccine called V181 in 12,000 healthy children aged 2 to 17. The goal is to see if the vaccine is safe, triggers a strong immune response, and reduces cases of dengue fever caused by any of the four dengue virus types. Participants will receive eithe…

This early-stage trial is testing an experimental mRNA vaccine called mRNA-1469 to see if it is safe and can trigger an immune response against Ebola-Bundibugyo virus disease. Healthy adults aged 18 to 65 will receive either the vaccine or a placebo. The study focuses on safety a…

This early-stage trial tests an experimental mRNA vaccine called YKYY025 designed to protect against respiratory syncytial virus (RSV). Healthy adults aged 18 and older receive a single injection of either the vaccine or a placebo. Researchers monitor safety, side effects, and im…

This early-stage study tests a new flu vaccine (STEMos1) in 56 healthy adults aged 18-50. Half of the participants get the vaccine with an adjuvant (a substance that boosts the immune response), and half get it without. The goal is to check safety and how well the vaccine trigger…

This phase 3 study tests an investigational meningococcal conjugate vaccine in healthy infants and toddlers aged 2 to 23 months in China. The vaccine targets four serogroups of meningococcal bacteria (A, C, W, Y) that can cause meningitis and bloodstream infections. Researchers c…

Researchers are testing whether a new oral polio vaccine called nOPV2, given at birth, helps infants block type 2 poliovirus in their intestines. The trial enrolls 740 healthy newborns who have received standard injected polio vaccines. Scientists will check stool samples for sig…

This study tests whether a vaccine can prevent C. difficile infection in adults 65 and older. About 32,000 participants will receive either the vaccine or a placebo shot. The study will track infections and side effects over up to three and a half years.

This phase 3 trial is investigating whether giving a repeat dose of the RSVpreF vaccine to immunocompromised adults is safe and triggers a strong immune response. Participants, aged 18 and older, will receive one shot and be monitored for about a year. The study aims to find the …

This study tests a new pneumococcal vaccine in healthy infants to see if it is safe and works better than the current vaccine. About 3,230 babies will receive either the new vaccine or the existing one at routine checkups. Researchers will compare side effects and immune response…

This study tests two experimental vaccines against Epstein-Barr virus (EBV), which causes mono and is linked to cancers. Researchers will give 750 healthy adults aged 18-29 three shots over several months to check for side effects and immune response. The goal is to find a safe v…

This study tests an experimental vaccine called V132 in healthy adults aged 50 and older. The goal is to see how safe it is and how well it triggers an immune response compared to existing pneumococcal vaccines. Participants will receive one of several formulations of V132 or a c…

This study compares three different flu vaccines in 60 adults with blood cancers like leukemia or lymphoma. The goal is to see which vaccine triggers the strongest immune response in people with weakened immune systems. Participants will receive one of the vaccines and have their…

This study tests a new pneumococcal vaccine (PG4) in healthy children aged 15 months to 18 years. About 1,200 participants will receive either the new vaccine or the current Prevnar 20. Researchers will compare safety and immune response over 6 months. The goal is to see if the n…

This large study will test the LC16m8 mpox vaccine in nearly 12,000 people aged one year and older in the Democratic Republic of Congo. Researchers want to see if the vaccine can prevent mpox disease and monitor its safety. Participants will receive the vaccine as part of the gov…

This trial tests whether a single dose of the 9-valent HPV vaccine triggers the same immune response as two doses in healthy adults aged 18 to 45. Researchers will measure antibody and B cell responses in blood, lymph nodes, and bone marrow. The goal is to understand how the vacc…

This first-in-human trial tests an experimental vaccine called LTB-NG6, designed to protect against gonorrhea. The study will enroll healthy adults aged 18-50 to evaluate the vaccine's safety and its ability to trigger an immune response. Participants will receive either the vacc…

This study tests whether a combination of a culturally tailored video message from an HPV cancer survivor and a reminder phone call can increase the number of adolescents aged 10-12 who get the HPV vaccine. The intervention is delivered through a patient portal and direct outreac…

This study is testing how well the 9-valent HPV vaccine (Gardasil9) triggers an immune response in people born male who have used estrogen or androgen blockers, including those living with HIV. Participants receive three doses of the vaccine over six months, and their immune resp…

This trial tests a new oral cholera vaccine called PanChol in healthy adults aged 18 to 55 in Zambia. The vaccine is designed to be safer and more effective than current options. Researchers will monitor participants for side effects and measure their immune response after vaccin…

This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the proce…

This study tests whether the antiviral drug molnupiravir can prevent severe illness from COVID-19 in adults at high risk. About 3,000 non-hospitalized participants will take either molnupiravir or a placebo for 5 days. The main goal is to see if the drug reduces hospitalizations,…

Researchers are testing a topical filmogel device called URGO MICKAEL on mild to moderate toenail fungus. About 54 adults with one or two damaged big toenails apply the device daily for up to six months. The study measures whether fungal cultures from the treated nail turn negati…

This study tests a new medicine called BI 765423 in 71 adults with idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and breathing problems. Participants receive either the drug or a placebo by infusion every four weeks for about 3 months. The main goal is …

This study tests whether a combination of three drugs (cyclophosphamide, bortezomib, and maraviroc) can safely prevent graft-versus-host disease after a half-matched bone marrow transplant in people living with HIV who also have a blood cancer. The trial involves 265 participants…

This study tests a new way to find and treat a type of malaria (P. vivax) that can hide in the liver and come back months later. Researchers will use a simple blood test to find people who have been infected recently, then give them a treatment to clear the hidden parasites. The …

This study tests a drug called felzartamab in people who received a kidney transplant and later developed microvascular inflammation (MVI), a type of injury to small blood vessels in the new kidney that can lead to serious problems. The trial includes 81 participants who will rec…

Researchers are testing whether regulatory T cells taken from donated thymus tissue can control the dangerous immune overreaction that occurs in severe COVID-19 and acute respiratory distress syndrome (ARDS). The trial enrolls adults aged 18 to 65 who are hospitalized with acute …

This study looks at whether an essential oil from Pelargonium graveolens (a type of geranium) can be used to treat deep cavities in children's baby teeth. The goal is to see if it works as well as current materials to relieve pain and prevent infection. Thirty children will recei…

This study tests whether a program that helps incarcerated men with HIV notify their sex and drug-use partners about possible HIV exposure can increase testing and treatment. Participants can choose to tell partners themselves or have a trained notifier do it anonymously. The goa…

This study will test a two-drug HIV pill (Dolutegravir/Lamivudine) in 210 pregnant women who have never taken HIV medication. The goal is to see if it controls the virus and prevents passing HIV to their babies. Participants will be compared to those on standard three-drug therap…

This study is testing whether giving fewer non-essential fluids to adults with septic shock can improve outcomes. The trial will enroll 1,850 patients in intensive care, comparing a restrictive fluid strategy to usual care. The main goal is to see if this approach reduces deaths …

This phase 3 trial is testing whether the oral antiviral secutrelvir can prevent severe COVID-19 in people who are at high risk for complications. Participants with mild symptoms and confirmed SARS-CoV-2 infection will receive either secutrelvir or a placebo. The study will measu…

This phase 1 study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs can shrink tumors. Up to 58 people with Kapo…

This phase 3 trial tests whether the oral drug rentosertib (INS018_055) can slow lung function decline in adults with idiopathic pulmonary fibrosis (IPF), a progressive lung disease. About 320 participants will receive either rentosertib or a placebo daily for 52 weeks. The main …

This study tests two doses of an experimental drug, zampilimab, against a placebo in 240 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The main goal is to see if the drug can improve lung function over 24 weeks, with an …

Researchers are testing venetoclax, a drug that prompts certain cells to self-destruct, in people living with HIV who take antiretroviral therapy. The goal is to see if it can safely reduce the size of the latent HIV reservoir, the hidden pool of virus that persists despite treat…

This study tests whether curcumin, the active compound in turmeric, can help regulate the overactive immune response in critically ill patients with sepsis. Fifty-six participants will receive either curcumin or a placebo alongside standard care for 10 days. Researchers will meas…

This phase 2 trial tests whether the drug nivolumab can slow or stop the growth of Epstein-Barr virus (EBV)-positive lymphoproliferative disorders and non-Hodgkin lymphomas. About 40 people aged 12 and older whose cancers have not responded to standard therapy will receive nivolu…

This Phase 2 trial tests whether a new drug called EL219 (Turletricin) is safe and effective for early treatment of invasive mould infections in people with weakened immune systems, such as those who have had a bone marrow transplant. About 60 participants will receive either EL2…

This study tests whether using a chat-based mobile app (Zalo) can help people follow through with recommended tests after an abnormal chest X-ray read by AI. About 2,692 adults in Vietnam at risk for lung cancer or TB will be randomly assigned to receive either standard results o…

This study tests whether a single dose of N-acetylcysteine (NAC), an antioxidant, can help adults with severe infections and liver dysfunction recover faster. 360 participants will receive either NAC or a placebo infusion within 24 hours of hospital admission. The main goal is to…

This study tests a new 6-month treatment called BPaLM for people with multidrug-resistant tuberculosis (MDR-TB). The goal is to see if it works as well as the current 18+ month regimen. About 55 adults in France will receive the shorter treatment, and their outcomes will be compa…

This study at the National Institutes of Health evaluates and treats people aged 3 and older with known or suspected parasitic infections, such as malaria, intestinal worms, and others. Participants receive standard medical care, not experimental treatments. The goal is to monito…

This study tests whether giving newborns plasma from people who recently recovered from chikungunya can prevent brain swelling or damage. The trial will include 60 newborns whose mothers were infected around the time of birth. Half will receive the plasma transfusion, and their o…

This study tests an experimental drug called LXE408 in 130 adults with chronic Chagas disease who do not have severe organ damage. The goal is to see if LXE408 can clear or reduce the parasite level in the blood over 6 months, compared to placebo and standard treatment. Participa…

Researchers are following 100 people newly diagnosed with Mycobacterium avium complex pulmonary disease (MAC-PD) who need standard three-drug antibiotic treatment. The study measures how many patients clear the infection after six months, how their bacterial load changes, and how…

This Phase 2 trial tests an experimental drug called EYU688 in 108 adults with dengue fever. Participants receive either the drug or a placebo to see if it lowers the amount of virus in the blood and shortens fever. The study is currently recruiting.

Researchers are testing whether an experimental drug called resomelagon can safely treat adults with dengue fever. The trial enrolls 120 adults who have had dengue symptoms for less than three and a half days. Participants receive either resomelagon or a placebo, along with stand…

This study tests whether IgPro20 (HIZENTRA), a concentrated antibody solution given under the skin, can prevent infections in people with multiple myeloma who have low antibody levels due to bispecific antibody therapy. About 100 participants will either receive IgPro20 plus stan…

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and reco…

This study is testing the drug letermovir to prevent cytomegalovirus (CMV) infection in children and teens who have had a kidney transplant and weigh less than 40 kg. About 40 participants will receive the drug to see how it moves through their bodies and if it is safe. The goal …

This study is for people with HPV-related throat cancer who have surgery to remove the tumor. Normally, some patients also get radiation afterward to lower the risk of cancer coming back. This trial tests whether it's safe to skip that radiation if a blood test two weeks after su…

This phase 3 trial tests whether adding trimodulin (a protein mixture from donated blood) to standard care can lower death rates in adults with severe community-acquired pneumonia who need a breathing machine. About 590 hospitalized patients will receive either trimodulin or a pl…

This study tests a new medicine called fosmanogepix for adults with serious mold infections that are hard to treat. About 234 people will join, receiving either the new drug or standard care. The main goal is to see if fewer people die by day 42. The study is currently recruiting…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This trial is testing a new ventilator called INBENTUS VERSATILE in 81 adults who need help breathing. The study checks if the device is safe and works well for conditions like ARDS, pneumonia, and COPD. Participants will use the ventilator for 3 to 48 hours and be monitored unti…

This study tests a new treatment called LBP-EC01, which uses specially designed viruses (bacteriophages) to attack drug-resistant E. coli bacteria that cause urinary tract infections (UTIs). About 318 adults with a history of UTIs and a current infection will receive either LBP-E…

This phase 2 trial tests whether an inhaled form of nintedanib (MNKD-201) is safe and effective for people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring. About 210 adults with IPF will receive either a low or high dose of the inhaled drug or a plac…

This Phase 3 trial tests a new drug called fosmanogepix against standard treatments for life-threatening Candida bloodstream or organ infections. About 450 adults will be randomly assigned to receive either fosmanogepix (first by IV, then as a pill) or the usual IV caspofungin fo…

This study compares two treatments after surgery for stage III-IVA head and neck cancer: radiation alone versus radiation plus the chemotherapy drug cisplatin. The goal is to see which approach better prevents the cancer from returning, especially in patients with certain TP53 ge…

This phase 2 trial tests an oral drug called PIPE-791 in 324 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Participants take either a low or high dose of PIPE-791 or a placebo daily for several months. The main goal is t…

Researchers are testing whether a higher daily dose of the antiviral drug entecavir suppresses hepatitis B virus better than the standard lower dose in adults whose livers are already scarred and failing. The trial enrolls 48 people with hepatitis B and decompensated cirrhosis. P…

This study tests whether giving a whole blood transfusion can help children under 5 with severe malaria and very low platelet counts survive. The trial is enrolling 132 children in Zambia. Researchers will compare death rates and blood changes between those who get a transfusion …

This study compares oral (pill) antibiotics to intravenous (IV) antibiotics for treating infected broken bones that haven't healed properly. About 250 adults with this condition will be randomly assigned to receive either oral or IV antibiotics for up to 6 weeks after surgery. Th…

This study tests whether adding immune cells from a family donor to standard antiviral drugs can help children and young adults clear stubborn adenovirus or cytomegalovirus infections after a stem cell transplant. About 69 participants will be randomly assigned to receive either …

This phase 2 trial tests whether adding the antibiotic ertapenem to standard cefazolin treatment improves outcomes for adults with methicillin-susceptible Staphylococcus aureus bloodstream infections. About 60 participants will receive either the combination or a placebo. The stu…

This study tests new combinations of drugs for adults with lung tuberculosis (TB). The goal is to see if these new regimens work faster and are safer than the current standard treatment. About 315 participants will receive either an experimental drug combo or the usual care for 8…

This Phase 2 trial tests an experimental drug called AHB-137 in 84 adults with chronic hepatitis B who are already on antiviral therapy. The goal is to see if AHB-137 can clear the hepatitis B surface antigen and keep the virus under control, potentially leading to a functional c…

This study tests whether a two-drug HIV regimen (dolutegravir plus lamivudine) works as well as the standard three-drug regimen in people who also have tuberculosis and are on TB treatment. About 150 participants who have never taken HIV medication will be randomly assigned to on…

This study tests whether transplanting vaginal fluid from healthy donors can restore a healthy bacterial balance in women with recurrent bacterial vaginosis (BV). Participants receive either the transplant or a placebo after antibiotic treatment. The goal is to see if the transpl…

This study tests a special blood-filtering device (DPCAS+LPE) in 192 adults with acute-on-chronic liver failure and sepsis. The device removes harmful inflammatory substances from the blood. Researchers will compare survival rates and organ function between patients receiving thi…

This study tests whether adding a probiotic called Lacticaseibacillus rhamnosus GG to standard care (like rehydration fluids) can shorten the duration of acute infectious diarrhea in children. About 480 kids aged 1 month to 10 years in Turkey will take part. Half will get the pro…

This study tests whether switching from the current drug bulevirtide to a new drug called brelovitug can better control chronic hepatitis Delta. About 120 adults who have been on bulevirtide for at least 6 months will take brelovitug for 24 weeks. The main goal is to see if the v…

This study tests whether injecting the antibiotic moxifloxacin directly into the cornea can help treat bacterial eye infections that don't improve with standard antibiotic drops. About 60 adults with stubborn corneal infections will receive either the injection plus drops or drop…

This study tests an experimental drug called recombinant human plasma gelsolin (rhu-pGSN) added to standard care for people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive eithe…

This study tests whether starting antiretroviral therapy within 7 days of an HIV diagnosis can reduce stigma and improve health outcomes for people who inject drugs. Researchers will develop a rapid-start strategy and pilot it with 135 participants at HIV clinics. The goal is to …

Researchers in Peru are studying whether moving HIV care from specialized hospitals to primary health clinics helps more people stay in treatment and keep the virus suppressed. The trial combines two training programs, NIATx and Project ECHO, to give primary care staff the skills…

This study tests whether washing out infected fluid from the brain's cavities (ventricular irrigation) can improve survival and recovery in people with severe ventriculitis, a life-threatening brain infection. About 310 adults aged 18-65 with confirmed ventriculitis will be rando…

This phase 2 trial tests whether applying a special gel (Geniwa gel) after laser removal can better treat recurrent genital warts and prevent them from returning. Adults who have had at least three laser treatments and still experience recurrences are eligible. Participants recei…

This study tests whether oral antibiotics (linezolid or amoxicillin) can effectively treat newborns at risk of congenital syphilis, compared to a standard penicillin shot. The goal is to find a safe, outpatient-friendly option that avoids long hospital stays. The trial involves 9…

This study tests whether giving very early and intensive antiretroviral therapy, plus an antibody, can help infants with HIV achieve remission—meaning the virus stays undetectable even after stopping treatment. Researchers will enroll about 1,120 infants and follow them for safet…

This phase 3 trial will test how well two different triple therapies—one using a standard acid reducer (proton pump inhibitor) and one using a newer drug (vonoprazan)—work to eliminate H. pylori infection. It will also see if adding zinc improves results. The study plans to enrol…

This study compares two common antibiotics, daptomycin and vancomycin, to see which one works better for adults with MRSA bloodstream infections. About 300 participants will be randomly assigned to one of the two drugs. The goal is to find which treatment leads to fewer complicat…

This study looks at whether people with HIV who need a liver transplant can safely receive a liver from a donor who also had HIV. Researchers will compare infections and cancer rates between those who get an HIV-positive donor liver and those who get an HIV-negative donor liver. …

This study tests whether an injectable combination of two experimental drugs, GS-3242 and lenacapavir, can control HIV-1 as well as the daily pill Biktarvy. About 700 people with HIV who have never taken antiviral treatment will receive either the injectable regimen or the standa…

This study tests a newer acid-blocking drug (vonoprazan) against a standard one, each combined with vitamin D or probiotics, to treat H. pylori infection. About 66 adults with confirmed H. pylori will receive one of three treatments for two weeks. The goal is to see which combina…

This study tests whether a once-weekly combination of two experimental drugs (islatravir and ulonivirine) works as well as the standard daily three-drug pill Biktarvy for people newly diagnosed with HIV-1. About 570 adults who have never taken HIV medication will be randomly assi…

This Phase 3 trial tests whether giving immune globulin (IGI) regularly can prevent serious infections in adults with multiple myeloma who are receiving a bispecific antibody therapy. About 183 participants will be randomly assigned to get IGI right away for 12 months or only aft…

This study offers continued access to HIV medications for children and adolescents who completed a previous Gilead HIV treatment study. About 350 participants will receive their study drug or switch to a standard HIV medication, and researchers will monitor for side effects. The …

This study looks at a newly recognized disease called KSHV Inflammatory Cytokine Syndrome (KICS), caused by a virus that can also lead to certain cancers. Researchers aim to learn more about the disease and test experimental treatments, including antiviral and chemotherapy drugs,…

This trial tests whether a special filter called oXiris, used during continuous blood purification, can lower endotoxin levels in adults with septic shock and acute kidney injury. Septic shock is a life-threatening condition where infection causes severe organ failure. The filter…

This study tests whether the drug emetine can help people hospitalized with dengue fever. About 600 adults aged 18 to 65 will take either a low or high dose of emetine or a placebo pill for 7 days. Researchers will track if the drug reduces deaths or stops the disease from becomi…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study tests whether adding hyperbaric oxygen treatment (breathing pure oxygen in a pressurized chamber) to standard care can lower the death rate in people with severe, fast-spreading soft-tissue infections. About 1,480 adults with surgically confirmed infection will be rand…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This Phase 2 trial tests an experimental inhaled medication called LTI-03 in about 120 people with idiopathic pulmonary fibrosis (IPF), a progressive lung disease that causes scarring and breathing difficulty. Participants will inhale LTI-03 or a placebo twice daily for 24 weeks.…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study compares different antibiotic strategies for people hospitalized with Gram-negative bloodstream infections. The goal is to find which approach leads to better outcomes, like survival and fewer complications, while also reducing the risk of antibiotic resistance. About …

This study tests a special device called PIVO Pro that lets doctors draw blood for infection tests through an IV line already in the arm, avoiding extra needle sticks. The goal is to see if this method reduces contamination of the blood sample compared to the usual way. About 1,1…

This phase 2 trial tests a new combination of an anti-PD-1 antibody (a type of immunotherapy) plus standard antiviral drugs in 120 adults with chronic hepatitis B. The goal is to achieve a functional cure, where the virus is no longer active and patients can stop medication. The …

This early-stage trial tests whether specially grown donor T cells can safely treat adenovirus infections in people with weakened immune systems, such as cancer patients. The cells are designed to target and kill the virus. The study will check for side effects and see if the inf…

This Phase 2 trial tests whether switching to a combination of two injectable drugs, GS-3242 and lenacapavir, works as well as staying on the daily pill Biktarvy for people with HIV who already have the virus under control. About 175 participants will be randomly assigned to eith…

This study looks at the best time to give hepatitis C medication to people without HCV who receive a kidney from an HCV-positive donor. One group starts the drug just before transplant and takes it for only 2 weeks; the other starts after transplant and takes it for 12 weeks. The…

This study tests whether a new antibiotic called polymyxin E2, given both through a vein and as a mist inhaled into the lungs, can safely cure hospital-acquired pneumonia caused by drug-resistant bacteria. About 48 adults with this serious lung infection will receive either the n…

This early-stage trial tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people vulnerable to severe infections. Researchers take a participant's own white blood cells, use mRNA to correct the genetic defect, and infuse the cells back. …

This phase 2 trial tests a combination of an anti-PD-1 antibody, interferon, and standard antiviral drugs in 120 adults with chronic hepatitis B. The goal is to boost the immune system to clear the virus and achieve a functional cure, where the virus stays under control without l…

This early-stage study tests whether giving two powerful antibodies along with a therapeutic HIV vaccine can help people with HIV control the virus after they stop their daily antiretroviral therapy. The trial enrolls 48 adults in Thailand who started HIV treatment very soon afte…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This Phase 3 trial tests YCANTH, a topical solution containing cantharidin (a substance from blister beetles), against a placebo for treating common warts. About 300 people aged 2 and older with at least one wart on their body (excluding certain areas) will receive either the act…

This phase 3 trial tests a chewable tablet called ZP5-9676 (flubendazole) against common intestinal worms like hookworm, roundworm, and whipworm. About 300 people aged 6 months to 59 years from high-risk areas will receive either the drug or a placebo. The goal is to see if the d…

This trial tests whether photodynamic therapy (PDT) can clear toenail fungus. People with a confirmed fungal nail infection will have a special gel applied to the affected nail, then exposed to red light. The study will check if the nail looks healthy and if the fungus is gone at…

This study tests a new treatment called FB301, a capsule containing beneficial bacteria, for women with an imbalance of vaginal bacteria who have had a failed frozen embryo transfer (IVF). Thirty women aged 18-40 will receive FB301 or a placebo during a mock IVF cycle, with some …

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of …

This study looks at whether people with HIV who have stopped their medication for at least 12 weeks can safely restart treatment with a single daily pill (B/F/TAF) on the same day they return to care. About 200 adults will take part to see if this quick restart helps lower the vi…

This study tests a new drug, LYT-100, against an existing one (pirfenidone) for idiopathic pulmonary fibrosis, a lung disease that gets worse over time. About 1,100 adults will take either drug three times daily for up to a year, and researchers will measure how well their lungs …

This trial tests whether combining an antifungal drug (itraconazole) with infrared heat therapy clears skin lesions from sporotrichosis better than either treatment alone. Sporotrichosis is a chronic fungal infection that can persist for months and become serious. Researchers wil…

This study tests an experimental drug called ABBV-142 in people with idiopathic pulmonary fibrosis (IPF), a rare lung disease that causes scarring and breathing problems. About 165 adults will receive either ABBV-142 or a placebo for 52 weeks to see if the drug is safe and can he…

This study tests whether efavirenz, a drug used for HIV, can help people with Creutzfeldt-Jakob disease (CJD) live longer. CJD is a rare, rapidly fatal brain disorder. The trial will enroll 246 adults and randomly assign them to receive either efavirenz or a placebo. The main goa…

This study tests an experimental drug called dovramilast in 45 adults with moderate to severe leprosy type 2 reaction, a painful skin condition. Participants receive either dovramilast (100 mg or 150 mg) or standard treatments like prednisolone or thalidomide. The goal is to see …

This study tests whether a probiotic supplement containing Lactobacillus crispatus can reduce the number of times bacterial vaginosis (BV) comes back in women who have had it repeatedly. About 156 women aged 18-45 will take either the probiotic or a placebo daily for 12 weeks aft…

This trial tests a two-part approach for viral warts: applying mild heat at 44°C to the largest wart and using a 3% hydrogen peroxide solution on all warts. The idea is that heating one lesion may rally the immune system to fight the virus elsewhere, while the peroxide works dire…

This phase 3 trial is testing whether the oral drug secutrelvir can help people with COVID-19 recover faster. The study involves about 1,200 nonhospitalized participants aged 12 to 75 who start treatment within 48 hours of symptom onset. Half will receive secutrelvir and half a p…

This early-phase trial is testing an oral drug called VK-2019 in 30 adults with a type of lymphoma (DLBCL) that is linked to the Epstein-Barr virus and has not responded to at least two prior treatments. Participants take the drug daily in 28-day cycles at one of three dose level…

This study tests an experimental drug called AZD4144 in 124 adults with sepsis who have also developed acute kidney injury. Participants receive either the drug or a placebo daily by IV while in the hospital. The main goal is to see if the drug helps maintain kidney function bett…

This Phase 2 trial tests whether an oral drug called ifetroban can slow the decline in lung function for people with idiopathic pulmonary fibrosis (IPF), a progressive lung-scarring disease. About 128 adults aged 40 and older with IPF will receive either ifetroban or a placebo da…

This phase 3 trial tests tabelecleucel, a cell therapy made from donor immune cells, in 115 organ or stem cell transplant patients who developed a rare cancer (EBV+ PTLD) after standard treatment failed. The goal is to see if it can shrink tumors and improve outcomes. Participant…

This pilot study tests whether giving angiotensin II early in the emergency department can help stabilize blood pressure in patients with septic shock. Twenty adults who need a standard drug called norepinephrine will receive angiotensin II as an add-on. The main goal is to see i…

This study tests whether a shorter treatment regimen (13-24 weeks) using a combination of drugs (bedaquiline, linezolid, pretomanid, and moxifloxacin) works as well as the standard longer treatment for people with a type of drug-resistant tuberculosis. About 400 adults with fluor…

This trial tests whether nursing home residents who become acutely ill can be safely assessed and treated at home by municipal acute care teams, with remote consultation from a senior hospital physician, instead of being sent to the hospital. Participating nursing homes are rando…

This early-stage trial is testing whether lab-made antibodies that target HIV are safe and how long they stay in the body. About 83 healthy adults without HIV will receive the antibodies by vein or under the skin, alone or in combination. The goal is to find the right dose and ch…

This trial tests a new way to treat Helicobacter pylori, a common stomach bacteria linked to ulcers and cancer. Researchers compare a staged regimen that gradually increases the amoxicillin dose against a standard 14-day dual therapy. The study enrolls adults with chronic gastrit…

This study tests whether the drug fisetin can reduce organ failure in adults aged 65 and older who have sepsis (a severe response to infection). Researchers will give participants either one or two doses of fisetin or a placebo, and measure changes in heart, lung, and kidney func…

This early-stage study tests a new antibody called BNT351 in 67 adults, both with and without HIV. The goal is to check safety, how long the antibody stays in the blood, and whether it can lower HIV levels in people with the virus. It is a first step toward possibly controlling H…

This early-stage trial is testing an experimental drug called GS-0415 in people with HIV who already have the virus well-controlled by standard antiretroviral therapy. The study will give single and multiple doses of GS-0415 to evaluate its safety, tolerability, and how the body …

This trial tests whether having clinical dietitians take the lead on nutrition care—rather than waiting for referrals—can help adult medical inpatients at risk of malnutrition. Researchers will compare a dietitian-driven model with usual care on three hospital wards, measuring le…

This study tests whether giving the oral drug midodrine early to sepsis patients with low blood pressure can help them stop needing IV blood-pressure medications sooner. Researchers will compare standard care plus midodrine to standard care alone in 308 adults. The goal is to see…

This study tests whether giving the drug vasopressin earlier or later during septic shock leads to better outcomes. Researchers will use a computer alert system to randomly assign 300 ICU patients to early or standard timing. The goal is to see if the timing can be reliably contr…

This trial compares two antiviral drugs, tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF), in pregnant women with high hepatitis B virus levels. The goal is to see if TAF can prevent passing the virus to the baby as effectively as TDF, but with fewer side effec…

This trial tests whether two experimental capsules, 2LEBV and 2LXFS, can reduce fatigue and other symptoms in people with an Epstein-Barr virus infection. Participants take one capsule daily for six months, either one of the study drugs or a placebo. The study measures changes in…

This trial tests whether a daily oral capsule called 2LVERU can clear common, flat, or plantar warts caused by HPV. Researchers compare the capsule against a placebo in 162 people aged 3 and older over 6 months. The main question is whether warts disappear completely by the end o…

This trial tests whether 2LHERP, an immune regulator available for over 20 years, can reduce the number of cold sore outbreaks in adults who get at least six per year. Participants take one capsule daily for six months, then researchers compare outbreak rates over a year against …

This trial tests whether giving a single dose of acoziborole to people who test positive for sleeping sickness antibodies, but show no active infection, can stop the disease from spreading in a community. Researchers will screen entire villages and treat all seropositive individu…

This trial tests whether a daily probiotic pill can improve gut health and lower heart disease risk in 250 people living with HIV who drink heavily. Heavy drinking changes gut bacteria, which may raise inflammation and heart disease risk. Researchers will measure changes in gut b…

This trial tests whether 2LPAPI, an immune regulator used for over 20 years, can help clear high-risk genital HPV infections faster than a placebo. Researchers will enroll 284 women aged 25 to 45 with a current high-risk HPV diagnosis. Participants receive either 2LPAPI or a plac…

This pilot trial explores whether a non-invasive cardiac output monitor (NICOM) can help guide fluid resuscitation in emergency department patients with sepsis and low blood pressure. Participants receive standard care, and some also undergo a one-time NICOM assessment that inclu…

This phase III trial compares a new, shorter radiation approach to the standard 7-week chemoradiation for patients with HPV-positive oropharynx cancer. The experimental treatment uses a precise, high-dose radiation boost to the tumor followed by a reduced-dose chemoradiation cour…

This trial investigates whether therapeutic plasma exchange — a procedure that filters the blood to remove harmful substances — can reduce deaths in critically ill children with severe sepsis or septic shock. Participants are randomly assigned to receive either standard sepsis ca…

This pilot study tests whether methylene blue, a compound with antiviral properties in lab tests, can reduce hepatitis B virus levels in people with chronic infection. Participants take methylene blue capsules for up to 6 months, with the dose possibly increasing if the initial d…

This phase III trial is testing whether adding dexamethasone, a widely used anti-inflammatory steroid, to standard care can improve outcomes for critically ill patients with severe hospital-acquired pneumonia who show signs of a strong inflammatory response. The study randomly as…

This trial tests whether treating hepatitis C in primary care clinics, with non-specialist doctors, works as well as the standard specialist care in Brazil. It also evaluates the use of rapid tests and self-testing to find more people with the infection. The goal is to see if a s…

This trial compares two ways of feeding very preterm infants (born before 32 weeks and under 1500 grams). One group receives a short period of small 'trophic' feeds for one day before advancing to full feeds, while the other receives trophic feeds for three days. The goal is to s…

This study investigates whether inhaling the antibiotic amikacin can better treat pneumonia caused by gram-negative bacteria in patients on veno-arterial ECMO (a heart-lung bypass machine). Standard antibiotics often fail in these patients, possibly because the bypass reduces blo…

This trial in Benin tests different ways to help caregivers give children a 3-day course of malaria prevention medicine each month for three months after leaving the hospital. The children, all under 10, were hospitalized with severe malaria or severe anemia. Some families get ho…

This trial tests an experimental drug called STAR0602, which is designed to help the immune system attack cancer cells. It is being studied in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or combined with chemotherapy, …

This study tests an enhanced Mentor Mother strategy, where trained peer counselors provide tailored support to pregnant and postpartum women living with HIV. The goal is to see if this approach can be successfully implemented and improve health outcomes, such as keeping mothers i…

This trial tests whether using a blood marker called procalcitonin (PCT) to guide antibiotic decisions can safely shorten treatment duration in children with bacterial infections in intensive care. About 296 children will be randomly assigned to either PCT-guided care or standard…

This trial tests whether two antiviral drugs, favipiravir and ribavirin, can help clear the virus faster in adults hospitalized with Crimean-Congo hemorrhagic fever (CCHF), a severe tick-borne infection. Participants will receive one of the drugs or optimized standard care, and r…

This trial tests whether a 12-week smell training program can help people who lost their sense of smell after COVID-19. Participants will sniff four different scents twice daily, with one group using rose, orange, clove, and eucalyptus, and another using cheese, coffee, strawberr…

This trial tests whether combining community health worker support with a smart pill bottle that tracks medication and sends reminders can improve HIV treatment adherence and viral suppression. The study enrolls 420 adults with HIV in Alabama, Louisiana, and Mississippi who have …

This pilot trial tests whether intravenous zanamivir, a drug already used for flu, can reduce vascular permeability — the dangerous blood vessel leakage that is the main cause of death in dengue fever. About 74 people with dengue and warning signs will receive either zanamivir or…

This trial investigates whether long-acting injectable antiretroviral drugs can control HIV better than standard oral pills in adults with AIDS-related lymphoma who are also receiving chemotherapy. Participants will receive one of three HIV treatment strategies—oral pills alone, …

This trial investigates whether a rapid C-reactive protein (CRP) blood test can help doctors decide when antibiotics are truly needed for adults with acute respiratory infections in Indonesian primary health clinics. Many such infections are viral and do not require antibiotics, …

This study tests whether giving people with HIV or those taking PrEP two dedicated case managers helps them achieve better financial stability, food security, and health outcomes. Participants will work with their case managers to set goals and stay connected to care. The trial c…

This trial tests whether a low-cost, point-of-care urine test can help people with HIV who are not virally suppressed stick to their antiretroviral therapy. Participants provide a urine sample that is immediately tested for the presence of the drug tenofovir. Based on the result,…

This trial investigates whether giving the protein albumin together with standard intravenous fluids during the first hours of treatment can reduce deaths in people with septic shock. About 2,400 adults arriving at emergency departments with septic shock will be randomly assigned…

This phase 1 study tests whether inhaling high doses of the antibiotic isoniazid is safe and tolerable for people with tuberculosis. Eight adults with known drug-sensitive TB will receive single inhaled doses of 200, 600, and 1200 mg, plus one intravenous dose for comparison. Res…

This study tests a community-designed strategy to deliver preventive chemotherapy to mobile and migrant populations in Nigeria, who often miss treatment for neglected tropical diseases like river blindness and schistosomiasis. Researchers will work with communities to map migrati…

This trial tests whether colchicine, an anti-inflammatory drug used for gout, can reduce inflammation in the coronary arteries of people with HIV who have high cardiovascular risk. Participants take either colchicine or a placebo daily for 96 weeks, and changes in artery inflamma…

This trial tests a special bone graft that releases the antibiotic tobramycin to treat infected knee replacements. The graft is placed during the first stage of revision surgery, with the goal of clearing the infection and promoting new bone growth. About 200 adults with infected…

This study tests an experimental therapy called YH02, a genetically modified virus designed to infect and destroy cancer cells. It is given as an injection directly into tumors in people with advanced solid tumors (such as head and neck cancer, breast cancer, or melanoma) that ha…

This trial investigates whether adding antibiotics (vancomycin and tobramycin) to bone graft material during hip replacement surgery can reduce the risk of serious joint infections. The study includes adults undergoing hip replacement who need bone graft, comparing those who rece…

This study tests whether faricimab (Vabysmo), an FDA-approved eye injection for other retinal diseases, can safely treat abnormal blood vessel growth in the eye caused by presumed ocular histoplasmosis syndrome. About 25 adults with this condition will receive an initial injectio…

This Phase 1 trial tests a new radioactive tracer called [18F]-Fluorocellobiose ([18F]FCB) for PET/CT scans. The goal is to see if it can help find invasive mold infections in the body. The study includes healthy volunteers and people with known fungal infections. Participants re…

This study tests a new technology called Pictura Bio that aims to detect respiratory viruses quickly and cheaply from nose or throat swabs. Researchers will collect samples from 1000 adults and children with suspected viral infections at a UK hospital. The data will be used to tr…

This study compares a rapid test that identifies pneumonia-causing bacteria in about one hour to standard lab methods that take 2-4 days. Researchers want to see if the faster test helps doctors choose the right antibiotics sooner for 150 hospitalized patients with pneumonia. The…

Researchers are studying adults with Clostridioides difficile infection to learn why some people get a repeat infection. The trial follows 750 patients across multiple hospitals, collecting blood for genetic testing and stool samples to examine gut bacteria. The goal is to build …

This study evaluates a new digital test that people can use at home to detect COVID-19 and influenza A and B from a nasal swab. Participants with symptoms will use the test themselves and compare the results to a standard lab PCR test. The goal is to see if the test is accurate e…

This study looks at whether offering a rapid syphilis test during family planning visits (for birth control or abortion) is practical and acceptable to patients. About 70 participants will get a fingerstick test with results in 10-15 minutes, instead of waiting days. The goal is …

Researchers test whether giving people education materials and free access to screening helps them get checked for colorectal cancer and hepatitis C. The trial enrolls adults ages 45 to 75 who receive care at community health centers and are not up to date on these screenings. Pa…

This study is testing two new blood test kits designed to diagnose syphilis. Researchers will collect blood samples from 1000 people, including those with symptoms, those at high risk, and healthy controls. The goal is to see how accurate these new kits are compared to standard l…

Researchers are studying whether a digital management platform can help diagnose liver cancer at an earlier stage in people with chronic liver disease. The study enrolls adults aged 18 to 75 with conditions such as chronic hepatitis B. The platform tracks patients and guides stan…

Preterm babies face a serious risk of late-onset sepsis, an infection that can be hard to diagnose quickly. This study checks whether monocyte distribution width, a measurement taken from a standard blood count, can accurately identify which preterm babies have the infection. Res…

This study is testing a new DNA-based test called Delve Detect CSF that looks for germs in spinal fluid. The goal is to see if using this test early, instead of as a last resort, helps doctors diagnose brain infections faster. About 400 people with suspected brain infections will…

This study will test whether a new urine-based test can accurately diagnose pneumococcal pneumonia in children under 5 in Malawi. Researchers will use 350 stored urine samples from healthy kids and those with pneumonia, comparing results to standard lab methods. If it works, this…

This study will test a new biomarker called t6A to see if it can help doctors diagnose bacterial infections in newborn babies early. Researchers will measure t6A levels in 210 infants who need blood tests for suspected infection. The goal is to find a more accurate way to detect …

This study compares two ways to diagnose a peritonsillar abscess (a pus pocket near the tonsils): the usual physical exam versus adding a small ultrasound probe inside the mouth. About 368 adults with suspected abscess will take part. The goal is to see if ultrasound improves acc…

This early study is testing a radioactive tracer called [18F]F-TMP that is injected into the body and then tracked with a PET/CT scan. The goal is to see if the tracer collects at sites of bacterial infection, making them visible on the scan. Twenty adults with known or suspected…

This study aims to validate a non-invasive malaria diagnostic tool that detects specific compounds in breath, called volatile organic compounds (VOCs), using a device called TRACE-E. Researchers will collect breath and blood samples from 200 people aged 12 and older with fever in…

This study tests a new liquid biopsy that measures TB DNA in fluid from around the lungs to diagnose tuberculous pleuritis, a common form of TB. Current methods often require invasive tissue biopsies or have low accuracy. The trial will enroll 350 adults with new-onset pleural ef…

Every year, millions of people with tuberculosis (TB) go undiagnosed. This study tests new, faster diagnostic tools that use a simple tongue swab instead of the usual sputum sample. Researchers will enroll 1,350 adults with cough or TB risk factors to see how accurate these point…

This study is testing new, non-invasive ways to diagnose tuberculosis (TB) in children under 15. Researchers will evaluate oral swabs, cough sound analysis, and lung sound analysis as potential alternatives to sputum tests. The goal is to find faster, simpler, and cheaper diagnos…

This study aims to build a massive screening cohort of one million people to improve early detection of nasopharyngeal carcinoma, a cancer linked to Epstein-Barr virus (EBV). Participants aged 30 to 69 will provide blood, saliva, and nasal brush samples for EBV antibody and DNA t…

This trial tests whether a newer type of CT scan, called photon-counting CT, can help doctors identify idiopathic pulmonary fibrosis (IPF) more accurately than the standard high-resolution CT scan. The study will enroll 156 adults with interstitial lung disease who need a multidi…

This trial evaluates whether a new self-collection device, Mia by XytoTest, can be used effectively by people to collect their own vaginal samples for cervical cancer screening. The study compares the accuracy of these self-collected samples against clinician-collected samples fo…

This study aims to create a homemade PCR test to detect echinococcosis, a parasitic disease, more quickly and accurately than current methods. Researchers will collect biological samples from patients suspected of having the infection, especially those undergoing surgery to remov…

This study evaluates whether a blood test measuring polyreactive immunoglobulin G (pIgG) can more accurately diagnose autoimmune hepatitis (AIH) and distinguish it from other liver conditions. Researchers will collect blood samples from 400 adults undergoing liver biopsy for susp…

This study collects blood samples from healthy people, those with benign diseases, and cancer patients to develop a multi-analyte blood test. The test looks for DNA methylation markers that may indicate the presence of various cancers, especially liver cancer. Researchers aim to …

This study is testing a new approach called PAC-Man to help prevent HIV from passing from mothers to their babies. About 2,426 mothers and infants in Malawi will take part. The goal is to see if this model helps more babies get tested for HIV early and ensures mothers receive pro…

This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to …

This phase 3 trial tests MK-8527, a once-monthly oral pill, to prevent HIV-1 infection in women. About 4580 HIV-negative women will take either MK-8527 monthly or a daily PrEP pill (Truvada) to see which works better and is safer. The goal is to offer a more convenient prevention…

Researchers are testing whether a three-session couples motivational interviewing program helps male couples reduce illicit drug use and behaviors that raise HIV transmission risk. The trial enrolls 360 male couples where at least one partner is HIV negative and at least one has …

Researchers are testing a clear plastic dome placed over a patient's head during surgery to see if it can stop the spread of airborne germs in hospitals. The trial enrolls 80 adults having elective surgery that requires a breathing tube. Participants are randomly assigned to have…

Karamoja in north-eastern Uganda is one of the most water-insecure regions in sub-Saharan Africa, and many schools lack enough latrines and menstrual health facilities. Researchers are running a three-arm cluster-randomised trial across 60 water-insecure primary schools to test a…

Researchers at one French hospital test whether repeated on-site simulation training helps ICU staff follow standard precautions more consistently. The training uses realistic scenarios that mimic common resuscitation situations, including interruptions and high cognitive load. T…

Researchers are testing whether giving the antibiotic zinacef during labor lowers infections for women with meconium-stained amniotic fluid at term and for their newborns. The trial enrolls 182 women with a single full-term pregnancy and meconium in the fluid. Half receive zinace…

This study looks at how well people stick to a new HIV prevention shot called lenacapavir. About 3,000 people in the U.S. who want or need HIV prevention will take part. Researchers will track who stays on the shot and how it works in everyday clinic settings.

Women treated for vulvar high-grade squamous intraepithelial lesion (vHSIL), a precancerous condition linked to HPV, often see it return. This trial tests whether giving the Gardasil 9 HPV vaccine alongside standard treatment (surgery, laser, or imiquimod) can lower that recurren…

This study compares the immune response from 2 doses versus the standard 3 doses of the HPV vaccine in women aged 27-45. About 618 participants will be randomly assigned to receive either 2 or 3 doses, and their antibody levels will be checked over 12 months. If 2 doses prove non…

Researchers are testing whether a bacterial lysate, a mix of inactivated bacteria, can reduce respiratory tract infections and wheezing in late-moderate preterm infants during their first years of life. The trial enrolls 500 infants born between 30 and 35 weeks of gestation, givi…

Researchers are studying how well two chikungunya vaccines, IXCHIQ and VIMKUNYA, prevent infection in adults during outbreaks on Réunion Island and in French Guiana. The study includes about 1,505 adults who are eligible for vaccination. By comparing infection rates between vacci…

This early-stage study tests a vaginal gel containing specially modified bacteria that produce an anti-HIV drug. The goal is to see if it is safe for healthy women and whether it can be cleared with antibiotics. If successful, this could become a long-lasting, woman-controlled HI…

This trial tests a police education program called SHIELD 2.0 in nine counties in Appalachian Kentucky. The program trains local behavioral health workers to teach police how to refer people who use drugs to treatment and social services instead of arresting them for low-level po…

This study tests an investigational nasal spray called INNA-051 to see if it can safely prevent or reduce the severity of viral respiratory infections like colds and flu. It involves 1100 healthy adults aged 18 to 45 who are at higher risk due to their living or work conditions. …

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

Researchers at Yale University are studying how to expand opioid agonist therapy (OAT) in prisons and probation systems in Tajikistan, Kyrgyzstan, Moldova, and Georgia. OAT uses medicines like methadone or buprenorphine to treat opioid dependence and can lower HIV transmission am…

This study tests a program called TENDAI4PrEP, which uses problem-solving techniques to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program also involves their partners and healthcare providers. Researchers will enroll 132 HIV-negative pregnant …

This early-stage study is testing an experimental antibody called MDX2301 to see if it can help prevent severe COVID-19 in healthy adults and those at higher risk. About 80 participants will receive either the antibody or a placebo, given as an injection or infusion. The main goa…

Researchers are studying whether short-course preventive treatment protects high school and college freshmen with strongly positive TB skin tests from developing active tuberculosis. About 3,000 students across 26 schools in Meishan City, Sichuan Province, China, take either a 3-…

This study is developing and testing a virtual reality tool to help young people aged 15-30 who have experienced trauma and are at risk for substance use and HIV. The goal is to see if the tool can reduce substance use and risky behaviors. Researchers are recruiting young men who…

This study in Tanzania tests whether giving boys a single dose of the HPV vaccine (Gardasil) can lower HPV infections in the community. Over 10,000 participants in 26 communities will be split: some communities vaccinate only girls (as usual), while others also vaccinate boys age…

This study tests a decision aid that helps women in sexual and reproductive health clinics decide whether to take PrEP, a daily pill that prevents HIV. The tool will be used during counseling visits. Researchers will see if it increases PrEP use and if it's practical for clinics.…

This study tests whether the oral medication venlafaxine, typically used for depression, can prevent postherpetic neuralgia—a persistent nerve pain that often follows a shingles rash. Researchers will enroll 832 adults who have had a shingles rash for less than 30 days and are ex…

This Phase 3 trial tests whether taking HIV prevention pills only around the time of sex can reduce the risk of HIV infection in men who have sex with men. Participants take either TAF/FTC or TDF/FTC, starting with a dose 2 to 24 hours before sex and another dose a day later. The…

This study tests a program in the Dallas County Jail that identifies people at high risk for HIV and offers them testing and education about PrEP, a daily pill that prevents HIV. A patient navigator helps interested individuals connect with PrEP providers after they are released.…

This study is testing a mobile app designed to help young Thai adults (ages 18-29) overcome stigma and start or stick with HIV prevention pills (PrEP). The app uses motivational interviewing and tailored content delivered over four sessions. Researchers will enroll 154 participan…

This study tests a combination of programs to help Black gay, bisexual, and same-gender-loving men in the New York City area get tested for HIV and start taking PrEP, a daily pill that prevents HIV. Participants receive one or more of the following: a 3-session empowerment worksh…

This trial tests a program called the Five Point Initiative, which brings HIV testing, PrEP education and prescriptions, and condoms to everyday spots like barbershops, salons, and corner stores in predominantly Black communities in Miami. Researchers want to see if this approach…

This trial tests whether methenamine hippurate, a non-antibiotic antiseptic, can prevent urinary tract infections (UTIs) as effectively as standard antibiotics in women receiving BOTOX-A injections for overactive bladder. Participants will be randomly assigned to take either meth…

This trial tests three ways to screen adolescents and young adults for HIV in emergency departments: targeted screening based on risk, universal opt-in screening offered to everyone, and universal opt-out screening where testing is done unless declined. The goal is to see which a…

This study is checking how effective the R21/Matrix-M malaria vaccine is at protecting children under 5 in Burkina Faso and Uganda, where malaria is common. Researchers will compare vaccination history in children who test positive for malaria against those who test negative. The…

This trial investigates whether a professional dental cleaning and instruction on proper brushing and flossing can reduce the amount of bacteria that enter the bloodstream during tooth brushing. Such bacteria can sometimes lead to infective endocarditis, a serious infection of th…

This trial tests whether offering a menu of HIV prevention options — including daily pills and a vaginal ring — helps more young women aged 18–30 start and continue using PrEP. About 1,400 women seeking reproductive health services at clinics in Kenya will be offered either stand…

This trial tests whether offering young people aged 15-30 in rural South Africa a choice of long-acting HIV prevention methods—such as a two-monthly injection or a vaginal ring—alongside standard daily pills and emergency prevention, increases how many start and stay on preventio…

This study compares two sedation methods for elderly ICU patients (65+) who need a breathing tube. One group gets a mix of propofol and ketamine, the other gets propofol alone. The goal is to see which causes fewer dangerous drops in blood pressure. The trial involves 41 particip…

This study tests whether virtual reality (VR) can help healthcare workers and COVID-19 patients with posttraumatic stress disorder (PTSD). Participants will use VR headsets during 10 therapy sessions over 5 weeks to safely revisit and overcome traumatic memories. The goal is to s…

This study tests whether doing tai chi/qigong over Zoom twice a week for 12 weeks can reduce depressive symptoms in people aged 50-75 living with HIV. About 326 participants will be randomly assigned to either tai chi or a health education class. Researchers will track mood, hear…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

Researchers are testing whether inhaling a concentrated saltwater mist, added to standard supportive care, can improve quality of life and help clear Mycobacterium avium complex (MAC) bacteria from the lungs. The trial enrolls 30 adults with nodular-bronchiectatic MAC lung diseas…

This study tests whether an extended-release form of nalbuphine, a pain medication, can safely reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. About 306 adults with IPF and a cough lasting at least 8 weeks will receive either t…

This study looks at whether a single injection of the antibiotic amikacin can effectively treat uncomplicated bladder infections in women visiting the emergency department. Instead of taking pills for several days, participants receive one shot into a muscle or vein. The goal is …

This study compares three different root canal sealers—AH Plus, ProRoot Bio Sealer, and BC Sealer ion+—to see which one leads to the least pain after treatment. About 135 adults with irreversible pulpitis in a lower molar will be randomly assigned to one of the three sealers. Pat…

This study tests an oral drug called vapendavir in 180 adults with COPD who catch a rhinovirus (common cold). The goal is to see if it can reduce the severity and length of breathing symptoms compared to a placebo. Participants are randomly assigned to one of two doses or a place…

Researchers at Minia University are testing whether the shape of a single-file rotary dental instrument affects how much debris gets pushed out of the root tip during a root canal, and whether that changes how much pain patients feel afterward. Thirty teeth with irreversible pulp…

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines proven methods to support smoking cessation and improve HIV/TB treatment results. Researchers will enroll 86 daily…

Researchers are testing whether taking omega-3 fish oil capsules every day for eight weeks, alongside standard tuberculosis treatment, helps the body clear the infection faster and lowers inflammation. The trial enrolls 40 adults aged 18 to 45 with newly diagnosed, drug-sensitive…

This study tests whether a 5-session online program teaching positive thinking skills can help people with HIV who use stimulants. Researchers want to see if it reduces stimulant use and depression by changing brain and immune function. 189 participants will be followed for 3 mon…

This study tests two different nerve block methods to control pain in people with multiple broken ribs. The goal is to see which technique provides better pain relief, helps patients breathe deeper, and shortens hospital stays. Thirty-six adults with at least two rib fractures wi…

This study tests whether a shared decision-making tool can help pharmacists and patients better understand when antibiotics are truly needed for uncomplicated cystitis (bladder infection). About 506 women with symptoms will be enrolled. The goal is to reduce unnecessary antibioti…

This study tests a 10-session peer-led program called Bridge to Belonging, designed to reduce loneliness and depression in older gay and bisexual men living with HIV. The program uses group sessions to build social skills and connect participants with LGBTQ+-affirming community s…

This study follows 500 adults in France who have either a genetic defect or autoantibodies that weaken their type I interferon immune response. Researchers will collect blood samples and health data over 1 to 4 years to track infections, autoimmune diseases, and cancers. The goal…

This study observes how many eligible infants in Queensland receive the RSV immunisation (nirsevimab) during their first RSV season. Researchers will survey 1,200 parents to understand why they chose for or against the shot, and look at factors like location and health risks. No …

This study aims to understand how Staphylococcus aureus bacteria interact with human cells to cause infections, especially in the spine. Researchers will use tonsil tissue discarded after routine tonsillectomies to create lab models. About 500 participants aged 2 and older who ar…

This study looks at how healthy people's skin and immune system respond to tick bites. Researchers will place clean, lab-bred ticks on volunteers' skin and take small skin samples and blood to track changes. The goal is to understand tick resistance and help design future vaccine…

This study aims to understand how the environment, the bacteria that cause melioidosis, and the human body interact to cause disease. Researchers will follow about 1,000 infected patients and 1,000 healthy matched controls in Thailand, Laos, and Cambodia for one year. They will a…

This study investigates whether the bacteria causing Lyme disease can survive antibiotic treatment and cause ongoing symptoms. Researchers will follow 700 participants, including those with chronic Lyme disease, recovered individuals, and healthy volunteers, using blood tests, sp…

This study aims to find the safest and most effective dose of a specific flu virus to give to healthy adults in a controlled setting. About 90 volunteers aged 18 to 55 will be exposed to the virus or a placebo and closely monitored. The goal is to create a reliable model for test…

Researchers are running an observational registry to study whether vonoprazan, an oral drug for heartburn and acid reflux, is safe to take during pregnancy. The study follows women aged 15 to 50 who took vonoprazan while pregnant and compares their outcomes with women who did not…

This study gathers fluid and tissue from the lungs and nose of healthy volunteers and people with a history of lung infections. Researchers will compare samples to find differences in immune function that might explain why some people are more prone to infections. Participants un…

This study aims to better understand trisomy 8 mosaicism, a rare genetic condition where some cells have an extra copy of chromosome 8, and its link to autoinflammatory disease (TRIAD). Researchers will follow affected individuals and their healthy relatives over time, collecting…

Researchers are observing how often children hospitalized with non-severe pneumonia receive antibiotics and how doctors decide whether a child needs them. The study follows 200 children admitted to two German hospitals, recording treatment choices, medical complications, and pare…

This study aims to learn more about non-tuberculous mycobacterial (NTM) infections, which cause repeated lung and other organ infections. Researchers will study up to 1,000 participants to understand the genetics, symptoms, and best treatments for these infections. The study also…

Researchers want to understand how HIV builds a hidden reservoir in the body when someone starts treatment during the earliest stage of infection. The study follows 70 recently infected people who begin combination antiretroviral therapy right away. Over two years, participants g…

This study investigates whether platelets—tiny blood cells involved in clotting—interact with HIV-infected immune cells in ways that affect the virus's ability to persist despite treatment. Researchers will collect blood samples from 90 adults with HIV who have had undetectable v…

Researchers follow people with HIV who took part in earlier HIV-NAT studies to see how their health changes over many years. The study collects information on treatment history, side effects, other illnesses, and lab results such as viral load and CD4 counts. By tracking a large …

Researchers are building a long-term health study of 150,000 children born in Victoria, Australia, and their parents. The study follows participants from birth over their lifetime, collecting data on health, development, and environment through surveys, biosamples, and linked rec…

The Pulmonary Fibrosis Foundation runs an online registry where people with pulmonary fibrosis or interstitial lung disease, their caregivers, and their family members can share information about their health and experiences. Participants enroll themselves and answer questions ov…

This study gives healthy adults a controlled malaria infection using donated blood containing the P. vivax parasite. Researchers will monitor how the infection develops, how the immune system responds, and whether mosquitoes can pick up the parasite from participants. The goal is…

Researchers at a dental institute in India are studying whether levels of two inflammation markers, IL-1beta and IL-6, in the tooth's pulp can predict how well a full pulpotomy works. The procedure removes the inflamed crown portion of the pulp, caps it with a mineral-based mater…

This study examines how a type of immune cell called gamma delta T cells adapt and function in critically ill patients, both with and without sepsis. Researchers will compare these cells in healthy people, non-septic ICU patients, and septic ICU patients. The goal is to understan…

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study aims to understand where HIV hides in the body when people stop their daily antiretroviral therapy (ART) for a short time. Fifty adults with HIV will either stay on ART or pause it for up to 90 days. Researchers will use PET/CT scans and take small tissue samples from …

Vasoplegic shock is a life-threatening drop in blood pressure that can lead to organ failure. Doctors at University Medical Centre Maribor are studying patients whose blood pressure stays too low despite standard drugs. They measure renin, an enzyme tied to blood pressure regulat…

This study looks at people who have had unusually severe or long-lasting viral infections, like serious cases of herpes, HPV, or the flu. Researchers want to find out if these people have hidden immune system or genetic problems that make them more vulnerable. Up to 600 participa…

This study screens up to 2,000 people who have or may have immune disorders that make them prone to infections, along with their healthy relatives. Researchers will use medical history, physical exams, blood tests, and genetic testing to better understand these conditions. The go…

This study looks at HIV that stays hidden in the body even when the virus is under control. Researchers will measure the 'latent HIV reservoir' in 130 Ugandans with HIV and compare it to similar groups in the US. Participants give blood samples and answer health questions. No new…

This study follows adults with a family history of genetic prion disease to see how and when the condition first appears. Participants undergo regular check-ins and genetic testing over many years. The goal is to map the natural course of the disease and identify early markers th…

This study aims to find out whether people with long COVID still have inactive remnants of the SARS-CoV-2 virus in their bodies. Researchers will collect tissue samples from 12 adults who have recovered from COVID-19, some with long COVID symptoms and some without. The goal is to…

This study looks at proteins in lung fluid from 750 people with pneumonia to find biomarkers that could reveal what's causing the lung inflammation. Participants undergo a standard bronchoscopy with lung washings, plus a blood draw. The goal is to better understand different type…

This study collects white blood cells from HIV patients through a process called leukapheresis to examine how the immune system responds to early treatment. Researchers aim to enroll 60 adults—30 with early HIV and 30 with chronic HIV—who are not yet on antiretroviral therapy. Pa…

This study looks at why some people with HIV develop Immune Reconstitution Inflammatory Syndrome (IRIS) after starting HIV medications. Researchers will use PET scans and lymph node biopsies to track inflammation and immune recovery in 300 adults. The goal is to better understand…

This study collects white blood cells and plasma from 400 people with HIV, including rare 'non-progressors' who control the virus without medication. Researchers will analyze immune responses and genetic markers to understand what makes these individuals special. The goal is to u…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood samples from up to 2,419 adults, both with and without HIV. Researchers will analyze these samples to compare genetic and protein differences. The goal is to better underst…

This study is looking for the germs that cause fevers in Cambodia, especially those spread by insects like mosquitoes. Researchers will use advanced genetic testing to find these germs in blood and nasal samples from 6,500 people. The goal is to better understand what is making p…

This study follows people infected with HTLV-I virus, some of whom develop a rare spinal cord condition called HAM/TSP. Researchers will track changes in symptoms, immune system markers, and virus levels over time. The goal is to better understand why only a few infected people g…

This study follows 600 people with GATA2 deficiency, a genetic disorder affecting the immune system and other body systems. Researchers aim to understand the full range of health problems it causes and why it affects people differently. Participants will have yearly check-ups for…

This study collects blood plasma and white blood cells from healthy volunteers and people with HIV using a procedure called apheresis. The samples are used for laboratory research on infectious diseases and immune function. Up to 3,000 participants aged 18 and older will be enrol…

This study looks at why some people with HIV who have very low virus levels in their blood still develop thinking and memory problems. Researchers will follow 1,150 participants—including healthy volunteers—for up to 10 years, using brain scans, blood tests, and spinal fluid samp…

This study aims to understand how and why eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are giv…

This study collects blood, urine, bone marrow, and tumor samples from people with hairy cell leukemia and other blood cancers, as well as from healthy volunteers. Researchers will use these samples to study the diseases and develop new treatments called immunotoxins, which use an…

This study screens up to 5,000 healthy adults aged 18-65 to see if they can join future research on infectious diseases like flu and Zika. Volunteers undergo a 3-5 hour checkup including blood tests, heart exam, and chest X-ray. The goal is to build a pool of eligible participant…

Researchers are studying people in Réunion and Mayotte who seek care for dengue, chikungunya, or Zika to understand why some cases become severe. The study collects blood and urine samples and asks patients about their quality of life. By comparing clinical, demographic, and envi…

Researchers at Shanghai Pulmonary Hospital are studying how much breathing force people with idiopathic or progressive pulmonary fibrosis can generate through inhaler devices of different resistances. Sixty participants will use a handheld tool called the In-Check DIAL G16, which…

This study aims to learn more about oropharyngeal carcinoma, a type of throat cancer that can be linked to HPV. Researchers will collect blood samples from 1,000 patients before treatment and at six follow-up visits, and also gather tumor tissue when available. The goal is to bet…

This study tests whether a chatbot called 'Pneumonia Care Helper' can improve the knowledge, attitudes, and caregiving skills of people caring for elderly pneumonia patients. 150 caregivers will either use the chatbot with educational videos for 5 days or receive standard paper i…

Researchers are studying the bacteria that live in burn wounds and how they relate to patient outcomes. The trial compares standard laboratory cultures with next-generation DNA sequencing to see if the newer method gives a clearer picture of the wound microbiome. Up to 400 adults…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

OPERA is a large observational database that collects health records from people treated for chronic conditions such as HIV, liver disease, inflammatory bowel disease, heart disease, rheumatic disease, and neurodegenerative disease. Researchers use the records to study how these …

This study enrolls up to 400 people with known or suspected infections or inflammatory diseases that are not covered by other research protocols. The goal is to evaluate patients using standard medical practices, generate new ideas for future studies, and train doctors. No experi…

This study compares two types of visual cues during treadmill walking in 36 athletes who had ACL reconstruction. One cue is a steady beat (isochronous), the other has natural fluctuations (fractal). The goal is to see which better restores natural walking patterns and brain activ…

This study looks at whether people with HIV have chronic pain because their bodies don't make enough natural painkillers (opioid peptides). Researchers will test pain sensitivity in 200 adults (with and without HIV) using heat, touch, and pressure. The goal is to understand the c…

Complicated urinary tract infections are hard to treat and often return, and doctors need better data on what drives treatment failure. This observational study follows thousands of patients with confirmed complicated UTIs across multiple sites, collecting information on their sy…

This study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understa…

Researchers in Moscow are studying patients who have knee or hip replacement surgery to learn why some develop serious infections around the implant. The study will follow 750 adults aged 45 and older, checking their immune status, mineral metabolism, and tissue samples before an…

This study follows 400 people with mitochondrial disease and their household members to learn how infections affect them. Researchers will analyze blood samples and health records to find immune patterns linked to severe illness. The goal is to improve care and identify potential…

Ventilator-associated pneumonia is a bacterial lung infection that can strike patients in intensive care who need a breathing machine. Researchers are building a network of European ICUs to observe these patients and prepare the groundwork for future trials of prevention, diagnos…

This study aims to understand how the human body responds to dengue virus infection, including in people who have had dengue before. Healthy volunteers aged 18 to 50 receive a single injection of a weakened dengue virus and are closely monitored for six months. Researchers measur…

Researchers are running a worldwide survey to learn how COVID-19 affects children and adults who have primary immune deficiencies, a group of rare inherited conditions that weaken the immune system. Doctors enter health information about their patients who had confirmed or probab…

This study aims to learn more about liver diseases like hepatitis B, C, and D by observing up to 8,050 participants over time. Participants will have yearly check-ups, blood and urine tests, and liver ultrasounds. Some may be offered experimental treatments if they qualify. The g…

This study looks at how viruses change the environment around tumors in people with lymphoma, lung cancer, or anal cancer. Researchers will analyze blood and tumor samples from 254 patients to understand why some cancers resist treatment. The goal is to find new ways to make anti…

This study looks at 800 healthy adults who have cryptococcosis, a fungal infection that usually only harms people with weak immune systems. Researchers want to learn why these otherwise healthy people get sick, how their immune system responds, and how the disease progresses over…

This study follows 1,590 adults who have had COVID-19 to track their symptoms and recovery over three years. Participants complete phone interviews and online surveys every three months. The goal is to describe the range of recovery experiences and identify factors that lead to p…

This study aims to develop quality indicators for early sepsis care in Sub-Saharan Africa. Researchers are using a modified Delphi method, gathering expert opinions through surveys and feedback meetings. The goal is to create a set of context-adapted indicators to improve sepsis …

This study enrolls healthy adults who are already part of a respiratory virus challenge study at the NIH. Participants wear a smartwatch and use a smartphone to track temperature, heart rate, coughs, and other health signals. The goal is to see if these devices can detect subtle …

This study will follow 2,000 people of all ages who visit their doctor with symptoms of an acute respiratory infection, like cough, sore throat, or runny nose. Researchers will collect information on symptoms, treatments, and lab results to better understand how these infections …

This study, run by the National Institute of Allergy and Infectious Diseases, collects blood and stool samples from up to 5,000 people of all ages who have or had COVID-19, as well as those heavily exposed but uninfected. Researchers will analyze immune responses and genetic fact…

This pilot study will test if parents can learn to use a digital otoscope (ear camera) at home to check for ear infections in their young children. About 40 children aged 1-4 who have had ear infections before will take part. Parents in the study group will get training and a dev…

This study collects biological samples like blood, saliva, and urine from 300 adults aged 18-70, both with and without blood disorders such as sickle cell disease and thalassemia. The goal is to use these samples for research to better understand these conditions and related dise…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study collects blood, urine, bone marrow, and tissue samples from over 1,200 adults with lymphoid cancers or precancerous conditions. The goal is to help researchers better understand cancer biology, which may lead to new methods for diagnosing or treating these diseases. No…

This study observes 600 patients in Korea who receive Zavicefta for complicated abdominal or urinary tract infections or hospital-acquired pneumonia. Researchers track side effects and how well the drug works. It is required by Korean regulators to ensure the drug's safety after …

This study tests whether a rapid nose swab test that detects three common respiratory viruses (COVID-19, flu, and RSV) can help doctors avoid prescribing antibiotics when they aren't needed. About 2,000 people with respiratory symptoms will be enrolled. Doctors will either prescr…

This observational study enrolls 2,500 people with HIV to build a detailed bank of blood samples and health records. Researchers will use these specimens to investigate how the virus behaves, why some people progress slowly or control the virus without medication, and how antiret…

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This study is recruiting 160 people — half who carry one copy of the cystic fibrosis (CF) gene and half who do not — to see if carriers have different risks for respiratory infections. Researchers will collect nasal cells and blood samples to measure how well the cells move chlor…

This study reviews medical records from up to 400,000 U.S. Veterans to see how COVID-19 treatments like Paxlovid and remdesivir are used and how well they work. It also looks at RSV and flu patterns. The goal is to improve treatment strategies for respiratory viruses in the VA he…

This study will include 2,600 adults scheduled for bladder tumor surgery. Half will get a standard urine culture before surgery; the other half will not. The goal is to see if skipping the test leads to more fevers or infections in the month after surgery. If it's safe, it could …

This study looks at why the antibiotic doxycycline, when taken after sex, prevents bacterial STIs in some people but not others. Researchers will measure doxycycline levels in hair, blood, and urine from 48 volunteers to develop better ways to track if people are taking the medic…

Researchers in Ethiopia are studying whether tuberculosis infection changes how the placenta develops and works. They will enroll 500 pregnant women at delivery clinics and use a blood test to identify those with TB infection. The team will compare placental tissue and infant out…

Researchers at University Hospital Bonn are following 300 adults who undergo knee or hip replacement surgery to understand how their recovery unfolds. The study measures quality of life, hand grip strength, and bone density before and after the procedure. The goal is to identify …

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short p…

This study will track 10,000 adults in Hong Kong with respiratory symptoms to measure how often RSV causes illness and how severe it gets. Researchers will collect nose and throat samples and blood tests over several weeks. The goal is to fill knowledge gaps about RSV in adults a…

This study follows 150 people with active or latent tuberculosis (TB) to collect blood, sputum, and tissue samples. The goal is to better understand how TB behaves in the body and how the immune system responds. Participants receive standard TB treatment as part of the study, but…

This study follows 150 adults with Kaposi sarcoma (KS) for up to 10 years to learn how the disease behaves, why it comes back, and how it affects the immune system and organs. Participants will have regular check-ups, scans, and biopsies, but no new treatments are being tested. T…

This study tests whether tracking changes in infection markers and blood culture results over time can help detect sepsis earlier and monitor treatment in adults with cancer. Researchers will follow 100 patients with suspected sepsis during their hospital stay and for up to 30 da…

This study is recruiting 100 adults with hard-to-treat nontuberculous mycobacterial (NTM) lung infections to see if phage therapy—using viruses that kill bacteria—can help. Researchers will collect blood and airway samples to find biological markers that show whether the treatmen…

This study collects blood, bone marrow, and tumor samples from 500 adults with cancer or pre-cancerous conditions. Researchers will use these samples to learn more about how cancers behave and why some respond differently to treatments. Participants provide samples over time and …

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect blood, spinal fluid, and brain scans over time to understand how the disease progresses. No treatment is given; the goal is…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes skin and lung infections. Researchers will follow 600 patients and their relatives over time, examining their health and genetics. The goal is to better understand the disease and improve c…

This study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …

This study looks at how leishmaniasis infections progress and respond to treatment. It involves up to 289 people aged 3 to 100 with known or suspected leishmaniasis. Researchers will collect blood and tissue samples to learn more about the disease and test different treatments. T…

This study collects blood samples from 2,000 adults with pulmonary fibrosis to find genetic traits that may explain why they developed the disease and why scarring patterns differ. Participants must be 18 or older and have a confirmed diagnosis. The goal is to better understand t…

This study will collect ear swabs from 40 people with malignant otitis externa, a severe infection of the ear canal that mainly affects people with diabetes or weakened immune systems. Researchers will culture the samples to identify the bacteria and fungi causing the infection a…

This study looks at how the antibiotic rifampicin is processed by the body in people with staphylococcal bone and joint infections, such as prosthetic joint infections and chronic osteomyelitis. Researchers will take blood samples from 40 participants to measure drug levels and b…

This study explores whether methane gas produced by gut microbes is linked to the progression of Parkinson's disease and related conditions like dementia. Researchers will measure breath methane levels in 200 adults—including those with Parkinson's, those at high risk (REM sleep …

This study investigates whether six specific Leishmania antigens can activate T-cells in blood and tissue samples from patients with visceral and cutaneous leishmaniasis. Researchers will compare responses before and after treatment, and against healthy volunteers, to see if thes…

This study aims to understand why some people develop Long COVID—persistent symptoms after a COVID-19 infection—by tracking symptoms over time and analyzing saliva samples. Researchers will follow 500 adults aged 18 to 75 who have previously tested positive for SARS-CoV-2, collec…

This research project is looking at people with interstitial lung diseases (which affect the tissue around the air sacs) and airway diseases (like COPD). The goal is to better understand how these conditions often occur together and with other health problems. By studying a large…

This study sets up a monitoring program to track pregnancy outcomes and newborn health in HIV-positive and HIV-negative women at clinics in the IeDEA network. Researchers will watch for complications like miscarriage, preterm birth, and congenital abnormalities. The goal is to be…

This study looks at whether a simple bedside check called capillary refill time (pressing on a fingernail to see how fast color returns) can be combined with a blood test to spot a hidden problem in septic shock. Sometimes blood flow to organs seems normal, but tissues are still …

This study in Odisha, India, aims to understand why malaria transmission persists in some areas despite control efforts. Researchers will follow about 3,000 residents to measure hidden infections that don't cause symptoms and may be missed by standard tests. They will also look f…

This study investigates whether certain Helicobacter bacteria other than H. pylori are present in people with various stomach conditions, including chronic gastritis, precancerous changes, and gastric cancer. Researchers will analyze biopsy samples from about 150 patients to meas…

This study is building a large national registry to track the safety and effectiveness of fecal microbiota transplantation (FMT) in patients with Clostridium difficile infections. It will follow adult patients receiving FMT as part of their routine care, as well as stool donors, …

This study follows 1,500 people with Epstein-Barr virus-positive T/NK-cell lymphoproliferative diseases — rare conditions where the virus drives abnormal immune cell growth. Researchers will collect medical history, treatment details, and blood samples to see how the diseases beh…

This study aims to develop a predictive model for mortality in critically ill patients who carry multidrug-resistant gram-negative bacteria (MDR-GNB). Researchers will follow about 1,500 adults in intensive care units (ICUs) who are colonized with these bacteria, tracking their i…

This study looks at whether the color-coded triage system (Red, Yellow, Green) used in Turkish emergency departments can accurately predict which children with fever will become seriously ill. Researchers will track 3,000 children aged 0-18 who come to the emergency room with a f…

This study follows intensive care unit (ICU) patients over at least 28 days to see how two types of bacteria—Klebsiella pneumoniae and Enterobacter cloacae—change and evolve in their gut. By analyzing weekly stool samples, researchers hope to understand how these bacteria become …

This study asks whether a simple, non-invasive reading from a standard pulse oximeter—the perfusion index—can help predict survival in people with sepsis or septic shock. Sepsis can impair blood flow to small vessels even when blood pressure looks normal, and this 'hidden' poor p…

This study follows 250 people newly diagnosed with HIV and 161 healthy volunteers over five years to see who develops metabolic fatty liver disease (MASLD). Researchers use annual blood tests, ultrasounds, and FibroScans to measure liver fat and stiffness. The goal is to uncover …

This study investigates whether the diversity of gut bacteria is linked to liver and kidney injury in people with sepsis. Researchers will collect stool and blood samples from 200 sepsis patients in intensive care and compare them with samples from healthy volunteers. By analyzin…

This study examines whether concentrating ovarian cancer surgery in specialized centers and changes in treatment during the COVID-19 pandemic affect how long patients live without their cancer returning. Researchers will follow about 200 women diagnosed with epithelial ovarian ca…

This study follows 800 adults who have recovered from COVID-19 to understand how their immune systems respond over the long term. By collecting blood samples and health data, researchers hope to uncover why some people develop lingering symptoms, known as Long COVID. The goal is …

This study tests whether it is possible to set up a system to monitor antibiotic resistance at a general referral hospital in semirural Kinshasa, Democratic Republic of Congo. Researchers will enroll about 210 patients with suspected bloodstream infections to collect blood sample…

This study aims to find undiagnosed cases of advanced liver fibrosis and viral hepatitis B and C in the general population of Seine Saint Denis, France. Using a combination of rapid diagnostic tests and a portable liver stiffness scanner (FibroScan), researchers will screen 600 a…

This study compares oxygen readings taken from the finger and the earlobe during a six-minute walk test in people with interstitial lung disease. The goal is to see if one location gives more accurate measurements of oxygen levels during exercise. The results could help doctors d…

This study tests whether adding electrochemical sensors to standard blood culture bottles can identify bacteria early, while the sample is still growing. Researchers will collect extra blood samples from 200 patients with suspected bloodstream infections and spike them with known…

This study develops a machine learning model to predict the risk of acute exacerbation within one year in patients with allergic bronchopulmonary aspergillosis (ABPA), a lung condition caused by allergic reactions to Aspergillus fungus. Researchers will analyze data from 200 stab…

This large observational study follows 13,000 UK adults to understand who gets COVID-19, how the disease progresses, and its long-term effects on physical and mental health. Researchers track risk factors, symptoms, and outcomes like hospitalization. The data may also serve as a …

This study looks for biological markers in the blood that could help diagnose and predict the course of three serious lung conditions: COPD, idiopathic pulmonary fibrosis (IPF), and lung cancer. Researchers will analyze blood samples from 120 adults with these diseases to find li…

This study investigates why some patients with septic shock develop a weakened immune system after the initial crisis, making them prone to further infections. Researchers will analyze blood samples from 305 intensive care unit patients to find biological markers that indicate im…

This study looks at the immune system's response in infants aged 6 months or younger who are hospitalized with RSV bronchiolitis. Researchers will collect nasal swabs and blood samples to measure immune markers like interferons and cytokines. The goal is to understand why some ba…

This study observes patients with suspected or diagnosed infections in central vascular grafts (like aortic grafts) to better understand how the body's immune system responds. Researchers will collect blood samples and clinical data over time, comparing infected patients to those…

This study looks at people with allergic bronchopulmonary aspergillosis (ABPA), a lung condition caused by an allergic reaction to a common fungus. Researchers want to see if having fungus detectable in sputum or lung fluid samples is linked to more frequent flare-ups or worse ou…

This research project looks at how medical oxygen and pulse oximetry (a device that measures oxygen levels in the blood) are used in hospitals in several countries. The goal is to understand what helps or hinders the effective use of oxygen, especially for children with condition…

This study follows 300 health workers in Cape Town, South Africa, who are at high risk of tuberculosis (TB) infection. Researchers will use a combination of existing and new tests every three months to track immune responses at the time of infection. The goal is to better underst…

This study investigates why only some people develop severe infections from common germs. Researchers will analyze blood and skin samples from 2,000 participants with rare, serious infections to find genetic differences that may weaken immune defenses. The goal is to identify spe…