New inhaled drug aims to fight deadly lung scarring
NCT ID NCT06968845
First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 13 times
Summary
This Phase 2 trial tests an experimental inhaled medication called LTI-03 in about 120 people with idiopathic pulmonary fibrosis (IPF), a progressive lung disease that causes scarring and breathing difficulty. Participants will inhale LTI-03 or a placebo twice daily for 24 weeks. The study measures safety, lung function, and changes in lung scarring via scans and questionnaires.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- LTI-03 (an experimental inhaled peptide)
- What this could lead to
- If successful, LTI-03 could offer a new treatment option that protects lung cells and reduces scarring, potentially slowing disease progression in IPF patients.
- What could go wrong
- This is an early Phase 2 trial with only 120 participants, so results may not confirm benefit. The drug is compared to placebo, and side effects or lack of efficacy are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Agaplesion Evangelisches Krankenhaus Mittelhessen
RECRUITINGGiessen, Hesse, 35398, Germany
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
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Baylor Scott and White Health
RECRUITINGTemple, Texas, 76508, United States
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Birmingham Chest Clinic
RECRUITINGBirmingham, Birmingham, B91 2JL, United Kingdom
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Box Hill Hospital
RECRUITINGBox Hill, Victoria, 3128, Australia
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Cedars Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
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Churchill Hospital
RECRUITINGOxford, Oxfordshire, OX3 7LE, United Kingdom
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Cleveland Clinic Florida
RECRUITINGWeston, Florida, 33331, United States
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El Paso Pulmonary Association
RECRUITINGEl Paso, Texas, 79902, United States
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Henry Ford Health
RECRUITINGDetroit, Michigan, 48202, United States
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
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Instytut Gruzlicy i Chrob Pluc
RECRUITINGWarsaw, Poland, 01-138, Poland
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Launceston Respiratory and Sleep Centre
RECRUITINGLaunceston, Tasmania, 7250, Australia
Contact Email: •••••@•••••
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Medical University of Łódź
RECRUITINGLodz, Łódź Voivodeship, 90-153, Poland
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National Jewish Health
RECRUITINGDenver, Colorado, 80206, United States
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Paradigm Clinical Research Centers, LLC
RECRUITINGSan Diego, California, 92108, United States
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Queen Elizabeth Hospital Birmingham
RECRUITINGEdgbaston, Birmingham, B15 2GW, United Kingdom
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Royal Brompton Hospital
RECRUITINGLondon, SW3 6HP, United Kingdom
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Royal Devon and Exeter Hospital
RECRUITINGExeter, Devon, EX2 5DW, United Kingdom
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Royal Infirmary of Edinburgh
RECRUITINGEdinburgh, Scotland, EH16 4SA, United Kingdom
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Royal Papworth Hospital
RECRUITINGTrumpington, Cambridge, CB2 0AY, United Kingdom
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Royal Prince Alfred Hospital
RECRUITINGCamperdown, New South Wales, 2050, Australia
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Salus Aegroti Praktyka Lekarska dr n. med. Grzegorz Gąsior
RECRUITINGSosnowiec, Silesian Voivodeship, 41-208, Poland
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The Lung Research Center, LLC
RECRUITINGChesterfield, Missouri, 63017, United States
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Thoraxklinik-Heidelberg gGmbH Studienzentrum ThoraxKliPS
RECRUITINGHeidelberg, Baden-Wurttemberg, 69126, Germany
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Twoja Przychodnia NCM
RECRUITINGNowa Sól, Lubusz Voivodeship, 67-100, Poland
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UAB Lung Health Center
RECRUITINGBirmingham, Alabama, 35233, United States
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University of Cincinnati Medical Center
RECRUITINGCincinnati, Ohio, 45267, United States
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University of Kansas Medical Center
RECRUITINGKansas City, Missouri, 66160, United States
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University of North Carolina at Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27514, United States
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University of Southern California
RECRUITINGLos Angeles, California, 90033, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84108, United States
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Westmead Hospital
RECRUITINGWestmead, New South Wales, 2145, Australia
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Yale University School of Medicine
RECRUITINGNew Haven, Connecticut, 06511, United States
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