New hope for rare liver disease: experimental drug GS-4321 enters human trials

NCT ID NCT07096193

Recruiting now Disease control Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests a new drug called GS-4321 for chronic hepatitis delta, a serious liver infection. First, healthy volunteers will help determine safe dosing. Then, people with the disease will receive multiple doses to see if the drug can reduce virus levels and improve liver health. The trial involves about 200 participants and is currently recruiting.

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Conditions

The condition(s) this trial relates to.

hepatitis D virus infection Hepatitis D, Chronic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS DELTA

Contacts and locations

Locations

Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 83301, Taiwan
Ditmanson Medical Foundation Chia-Yi Christian Hospital
RECRUITING

Chiayi City, Taiwan
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, SC Gastroenterologia ed Epatologia
RECRUITING

Milan, 882, Italy
Fundatia Dr. Victor Babes
RECRUITING

Bucharest, 030303, Romania
Gastromedica S.R.L.
RECRUITING

Iași, 700506, Romania
IMSP Spitalul Clinic de Boli Infectioase "Toma Ciorba"
RECRUITING

Chinsinau, 2004, Moldova
IMSP Spitalul Clinic de Boli Infectioase "Toma Ciorba"
RECRUITING

Chisinau, 2004, Moldova
Infectious Diseases Institutul National De Boli Infectioase Prof. Matei Bals
RECRUITING

Bucharest, 21105, Romania
Institutul National De Boli Infectioase Prof. Dr. Matei Bals
RECRUITING

Bucharest, 021105, Romania
Investigative Site
RECRUITING

Anaheim, California, 92801, United States
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Korea University Ansan Hospital
RECRUITING

Ansan-si, 425-707, South Korea
Medizinische Hochschule Hannover
RECRUITING

Hanover, 30625, Germany
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
PMSI Clinical Republican Hospital "Timofei Mosneaga"
RECRUITING

Chisinau, MD-2025, Moldova
Samsung Medical Center
RECRUITING

Seoul, 135-710, South Korea
The Catholic University of Korea Bucheon St. Mary's Hospital
RECRUITING

Bucheon-si, 14647, South Korea
The Catholic University of Korea, Seoul St. Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
The New York-Presbyterian Hospital
RECRUITING

New York, New York, 10021, United States
University Multi-profile Hospital for Active Treatment "SofiaMed" 00D
RECRUITING

Sofia, 1797, Bulgaria
University of Louisville, Clinical Trials Unit
RECRUITING

Louisville, Kentucky, 40202, United States
University of Maryland, Institute of Human Virology, Clinical Research Unit
RECRUITING

Baltimore, Maryland, 21201, United States