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Could a poop pill help heal after colon surgery?

NCT ID NCT06370884

Recruiting now Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of days after surgery and are followed for up to 6 months to check for side effects and changes in their gut microbiome. The goal is to see if this approach is safe enough to study further for preventing infections like recurrent C. diff.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
intestinal microbiota transplant (IMT) solution
What this could lead to
If it works, this could point toward a way to restore healthy gut bacteria after colon surgery and reduce complications like recurrent C. diff infection.
What could go wrong
This is a very early Phase 1 pilot study with only 40 people, so it is designed just to test safety and feasibility, not effectiveness. There is a small risk of bowel perforation from the feeding tube, and the transplant may not engraft or provide benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Clostridium difficile colitis Clostridium infectious disease diverticulitis sigmoid colon cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLONIC SURGERY RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION

Contacts and locations

Locations

  • University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55414, United States

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