New drug trial aims to tame rare brain inflammation
NCT ID NCT05503264
First seen Jun 26, 2026 · Last updated Jul 10, 2026 · Updated 3 times
Summary
This Phase 3 trial tests satralizumab, an injected drug, in 120 people with NMDAR or LGI1 encephalitis—rare conditions where the immune system attacks the brain. The goal is to see if the drug improves disability and reduces the need for rescue treatments. Participants receive either satralizumab or a placebo for up to 52 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- satralizumab (Enspryng)
- What this could lead to
- If successful, satralizumab could offer a new treatment option to control symptoms and reduce disability in people with autoimmune encephalitis.
- What could go wrong
- This is an early Phase 3 trial with only 120 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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A. O. U. Federico II
Naples, Campania, 80131, Italy
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AOU Policlinico Giaccone
Palermo, Sicily, 90129, Italy
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Affiliated Hospital of Jining Medical University
Jining, 272029, China
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Ageo Central General Hospital
Saitama, 362-8588, Japan
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Beijing Children's Hospital, Capital Medical University
Beijing, 100045, China
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Beijing Tiantan Hospital,Capital Medical University
Beijing, China
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Beijing Tongren Hospital
Beijing, 100730, China
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Brigham and Women's Hospital Department of Neurology
Boston, Massachusetts, 02115, United States
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CEDOES - Diagnóstico e Pesquisa
Vitória, Espírito Santo, 29055-450, Brazil
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CHRU - Hôpital Bretonneau
Tours, 37000, France
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Centro de Pesquisas Clinicas
São Paulo, São Paulo, 01228-200, Brazil
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Chang Gung Memorial Hospital - Linkou
Taoyuan City, 333, Taiwan
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Chiba University Hospital
Chiba, 260-8677, Japan
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Children's Healthcare of Atlanta Center for Advanced Pediatrics
Atlanta, Georgia, 30329, United States
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Childrens National Health Center
Washington D.C., District of Columbia, 20010, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44915, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Erasmus MC
Rotterdam, 3015 GD, Netherlands
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Fakultni nemocnice v Motole
Prague, 150 06, Czechia
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Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Lombardy, 20133, Italy
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Fondazione Istituto Neurologico Mondino IRCCS
Pavia, Lombardy, 27100, Italy
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Fujian Medical University Union Hospital
Fuzhou, 350001, China
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Fujita Health University Hospital
Aichi, 470-1192, Japan
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Fukuoka University Hospital
Fukuoka, 814-0180, Japan
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Gifu University Hospital
Gifu, 501-1194, Japan
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Hadassah University Hospital Ein Kerem
Jerusalem, 9112001, Israel
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Hoag Memorial Hospital
Newport Beach, California, 92658, United States
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Hokkaido University Hospital
Hokkaido, 060-8648, Japan
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Hopital Pitié Salpétrière - CHU
Paris, 75651, France
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Hopital neurologique Pierre Wertheimer - CHU Lyon
Bron, 69677, France
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Hospital Alvaro Cunqueiro
Vigo, Pontevedra, DUMMY_VALUE, Spain
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Hospital Britanico
Ciudad Autonoma Bs As, C1280AEB, Argentina
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Hospital General Universitario Gregorio Marañon
Madrid, 28007, Spain
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Hospital Geral de Fortaleza
Fortaleza, Ceará, 60175-295, Brazil
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Hospital Israelita Albert Einstein
São Paulo, São Paulo, 05652-000, Brazil
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Hospital Ramos Mejía
CABA, C1221ADC, Argentina
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Hospital Regional Universitario de Malaga ? Hospital General
Málaga, 29010, Spain
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Huashan Hospital, Fudan University
Shanghai, 200040, China
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Hyogo prefectural Kobe Children's Hospital
Hyogoken, 6500047, Japan
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IRCCS Ospedale San Raffaele
Milan, Lombardy, 20132, Italy
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Instituto de Neurologia de Curitiba
Curitiba, Paraná, 81210-310, Brazil
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Instytut Psychiatrii i Neurologii II Klinika Neurologiczna
Warsaw, 02-957, Poland
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Irccs A.O.U.San Martino Ist
Genoa, Liguria, 16132, Italy
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Johns Hopkins Hospital
Baltimore, Maryland, 21205, United States
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Juntendo University Hospital
Tokyo, 113-8431, Japan
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Kagoshima City Hospital
Kagoshima, 890-8760, Japan
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Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, 00833, Taiwan
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Kindai University Hospital
Osaka, 590-0197, Japan
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Kitasato University Hospital
Kanagawa, 252-0375, Japan
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Kobe University Hospital
Hyōgo, 650-0017, Japan
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Komfo Anokye Teaching Hospital
Kumasi, Ghana
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Kyushu University Hospital
Fukuoka, 812-8582, Japan
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Mayo Clinic - Rochester
Rochester, Minnesota, 55905, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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NYU-Langone Medical Center
New York, New York, 10016, United States
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National Neuroscience Institute
Singapore, 308433, Singapore
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National University Hospital (NUH)
Singapore, 117599, Singapore
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Nihon University Itabashi Hospital
Tokyo, 173-8610, Japan
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Odense Universitetshospital, Neurologisk Afdeling N
Odense C, 5000, Denmark
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SPSK nr 1
Zabrze, 41-800, Poland
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Sanatorio del Sur S.A.
San Miguel de Tucumán, T4000IDK, Argentina
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Seoul National University Hospital
Seoul, 03080, South Korea
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St.Marianna University School of Medicine hospital
Kanagawa, 216-8511, Japan
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Szpital Uniwersytecki w Krakowie
Krakow, 30-688, Poland
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Tel Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
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The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325035, China
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The University of Osaka Hospital
Osaka, 565-0871, Japan
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Tohoku University Hospital
Miyagi, 980-8574, Japan
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Tokai University Hospital
Kanagawa, 259-1193, Japan
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UC San Diego
La Jolla, California, 92037, United States
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UCSF- Multiple Sclerosis Centre
San Francisco, California, 94158, United States
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University Hospitals of Cleveland
Cleveland, Ohio, 44106, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35233, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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University of Maryland Medical Center
Baltimore, Maryland, 21201, United States
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University of Texas at Houston
Houston, Texas, 77030, United States
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West China Hospital - Sichuan University
Chengdu, 610047, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.