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New hope for hepatitis delta: can switching drugs clear the virus?

NCT ID NCT07454837

Recruiting now Disease control Sponsor: Mirum Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests whether switching from the current drug bulevirtide to a new drug called brelovitug can better control chronic hepatitis Delta. About 120 adults who have been on bulevirtide for at least 6 months will take brelovitug for 24 weeks. The main goal is to see if the virus becomes undetectable in the blood.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hepatitis D virus infection Hepatitis D, Chronic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS D

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Barts Health NHS Trust

    RECRUITING

    London, E12AT, United Kingdom

  • CHU Grenoble Alpes Hopital Nord Michallon

    RECRUITING

    Grenoble, 38700, France

  • CHU Limoges

    RECRUITING

    Limoges, 87000, France

  • CHU Toulouse Hospital Rangueil, Toulouse

    RECRUITING

    Toulouse, 31400, France

  • CHU de Bordeaux

    RECRUITING

    Bordeaux, 33076, France

  • Cardiff and Vale University Health Board

    RECRUITING

    Cardiff, CF14 4XW, United Kingdom

  • Castle Hill Hospital

    RECRUITING

    Cottingham, Yorkshire, HU165JQ, United Kingdom

  • Centrul Medical Unirea S.R.L

    RECRUITING

    Iași, Lasi, 700023, Romania

  • Chelsea and Westminster Hospital

    RECRUITING

    London, SW109NH, United Kingdom

  • Clermont-Ferrand University Hospital

    RECRUITING

    Clermont-Ferrand, 63100, France

  • Clinical Hospital for Infectious and Tropical Diseases Dr. Victor Babes

    RECRUITING

    Bucharest, 030303, Romania

  • Fakultni Nemocnice Brno (University Hospital Brno)

    RECRUITING

    Brno, 62500, Czechia

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    RECRUITING

    Milan, 20122, Italy

  • Fundeni Clinical Institute

    RECRUITING

    Bucharest, 022328, Romania

  • Goethe University Frankfurt

    RECRUITING

    Frankfurt, 60323, Germany

  • Henri Mondor University Hospital (APHP)

    RECRUITING

    Créteil, 94000, France

  • Hopital Saint-Eloi

    RECRUITING

    Montpellier, 34090, France

  • Hospital Beaujon

    RECRUITING

    Clichy, 92110, France

  • Hospital Clinic I Provincial De Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital De La Croix Rousse

    RECRUITING

    Lyon, 69004, France

  • Hospital Universitario Ramon y Cajal

    RECRUITING

    Madrid, 28034, Spain

  • Institut klinicke a experimentalni mediciny- IKEM (Institute for Clinical and Experimental Medicine)

    RECRUITING

    Prague, 14021, Czechia

  • King's College Hospital NHS Foundation Trust

    RECRUITING

    London, SE5 9RS, United Kingdom

  • Klin Med Ltd. (KLIN MED s.r.o.)

    RECRUITING

    Prague, 12000, Czechia

  • Manchester University Nhs Foundation Trust

    RECRUITING

    Manchester, M13 9WL, United Kingdom

  • Medical University of Graz

    RECRUITING

    Graz, 8010, Austria

  • Medizinische Hochschule Hannover

    RECRUITING

    Hanover, 30625, Germany

  • Medizinische Universitat Innsbruck

    RECRUITING

    Innsbruck, A-6020, Austria

  • National Institute Of Infectious Diseases Prof. Dr. Matei Bals

    RECRUITING

    Bucharest, 021105, Romania

  • National Institute Of Infectious Diseases Prof. Dr. Matei Bals

    RECRUITING

    Bucharest, 21105, Romania

  • Pitie-Salpetriere Hosptial

    RECRUITING

    Paris, 75013, France

  • Spitalul Clinic de Boli Infectioase Constanta

    RECRUITING

    Constanța, 900709, Romania

  • Universitatsmedizin Rostock

    RECRUITING

    Rostock, 18057, Germany

  • University Hospital of Dusseldorf

    RECRUITING

    Düsseldorf, 40225, Germany

  • Vall d'Hebron Hospital

    RECRUITING

    Barcelona, 08035, Spain