New hope for hepatitis delta: phase 3 trial launches

NCT ID NCT07200908

Recruiting now Disease control Sponsor: Mirum Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial compares a new drug, brelovitug, to an existing treatment (bulevirtide) for chronic hepatitis delta, a serious liver infection. About 172 adults with the infection will receive either drug to see which better controls the virus and normalizes liver enzymes. The goal is to find a more effective long-term treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: brelovitug (also called BJT-778)
What this could lead to: If it works, this could offer a more effective long-term treatment option for people with chronic hepatitis delta, potentially improving liver health and reducing the virus.
What could go wrong: This is a phase 3 trial, but it's still early to know if brelovitug is truly better or safer than the existing drug. Side effects are possible, and the study is relatively small (172 people).

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Conditions

The condition(s) this trial relates to.

hepatitis D virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS D INFECTION

Contacts and locations

Locations

AOU Pisana - Cisanello
RECRUITING

Pisa, 56126, Italy
Barts Health NHS Trust
RECRUITING

London, E12ES, United Kingdom
CHU Grenoble Alpes Hopital Nord Michallon
RECRUITING

La Tronche, 38700, France
CHU de Bordeaux - Hopital Haut-Leveque
RECRUITING

Pessac, 33604, France
Centre Hospitalier Universitaire De Rennes
RECRUITING

Rennes, 35000, France
Centre Hospitalier de Versailles _ Hopital Andre Magnot
RECRUITING

Le Chesnay, 78157, France
Centrul Medical Unirea S.R.L
RECRUITING

Iași, Lasi, 700023, Romania
Chelsea and Westminster Hospital NHS Foundation Trust
RECRUITING

London, London, SW10 9NH, United Kingdom
Fakultni Nemocnice Brno
RECRUITING

Brno, Brno, 62500, Czechia
Fakultni Nemocnice Hradec Kralove
RECRUITING

Hradec Králové, Hradec Králové, 500 03, Czechia
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, 20122, Italy
Goethe University Frankfurt
RECRUITING

Frankfurt, Frankfurt, 60590, Germany
HOCH Health Ostschweiz
RECRUITING

Sankt Gallen, St.Gallen, 95 9007, Switzerland
Hospital Clinic Provincial De Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Universitari Vall D Hebron
RECRUITING

Barcelona, Barcelona, 08035, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, 39008, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Torrecardenas
RECRUITING

Almería, Almeria, 04009, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital Universitario Álvaro Cunqueiro
RECRUITING

Vigo, 36312, Spain
Hull University Teaching Hospitals
RECRUITING

Cottingham, HU16 5JQ, United Kingdom
Hôpital Beaujon
RECRUITING

Clichy, 92110, France
Hôpital Estaing
RECRUITING

Clermont-Ferrand, 63000, France
Hôpital Pitié Salpêtrière
RECRUITING

Paris, 75013, France
Hôpital Rangueil
RECRUITING

Toulouse, 31059, France
Hôpital de la Croix-Rousse
RECRUITING

Lyon, 69004, France
Hôpitaux Universitaires
RECRUITING

Geneva, Canton of Geneva, 1205, Switzerland
Institute For Clinical And Experimental Medicine
RECRUITING

Prague, Prague, 140 00, Czechia
Karolinska University Hospital
RECRUITING

Huddinge, 14186, Sweden
King's College Hospital NHS Foundation Trust
RECRUITING

London, SE5 9RS, United Kingdom
Klin Med s.r.o.
RECRUITING

Prague, Prague, 2 120 00, Czechia
Krajská nemocnice Liberec, a.s.
RECRUITING

Liberec, Liberec, 460 01, Czechia
Lille Regional University Hospital Centre
RECRUITING

Lille, 59000, France
Medical University of Graz
RECRUITING

Graz, 8036, Austria
Medizinische Hochschule Hannover
RECRUITING

Hanover, 30625, Germany
National Institute Of Infectious Diseases
RECRUITING

Bucharest, Bucharest, 021105, Romania
National Institute of Infectious Diseases Lazzaro Spallanzani
RECRUITING

Roma, 00149, Italy
National Institute of Infectious Diseases Prof Dr Matei Bals
RECRUITING

Bucharest, 021105, Romania
North Manchester General Hospital
RECRUITING

Manchester, Manchester, M8 5RB, United Kingdom
Queen Elizabeth Hospital Birmingham
RECRUITING

Birmingham, Birmingham, B15 2GW, United Kingdom
Rostock University Medical Center
RECRUITING

Rostock, Rostock, 18057, Germany
Spitalul Clinic De Boli Infectioase Si Tropicale Dr. Victor Babes
RECRUITING

Bucharest, Bucharest, 030303, Romania
Spitalul Clinic de Boli Infectioase Constanta
RECRUITING

Constanța, 900709, Romania
University Hospital Henri Mondor - APHP
RECRUITING

Créteil, 94000, France
University Hospital Limoges
RECRUITING

Limoges, 87042, France
Universitätsklinikum Düsseldorf
RECRUITING

Düsseldorf, 40225, Germany
Universitätsklinikum St. Pölten
RECRUITING

Sankt Pölten, 3100, Austria
Universitätsspital Zürich
RECRUITING

Zurich, 8091, Switzerland

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