Liver drug bulevirtide tested in people with liver problems
NCT ID NCT05765344
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 1 study looked at how the drug bulevirtide (Hepcludex) behaves in the body of people with normal liver function and those with liver impairment. Researchers measured drug levels in the blood and how quickly it is cleared. The study involved 74 participants and aimed to understand dosing needs for patients with liver issues.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bulevirtide (also known as Hepcludex or Myrcludex B)
What this could lead to
If successful, this study could help doctors determine the right dose of bulevirtide for patients with liver problems.
What could go wrong
This is an early Phase 1 study focused on drug levels, not on treating disease. It may not lead to any new treatment or change in practice.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Clinical Pharmacology of Miami, LLC
Miami, Florida, 33014, United States
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Orange County Research Center
Lake Forest, California, 92630, United States
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Orlando Clinical Research Center
Orlando, Florida, 32809, United States
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Pinnacle Clinical Research LLC
San Antonio, Texas, 78229, United States
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Texas Liver Institute
San Antonio, Texas, 78215, United States
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University of Miami
Miami, Florida, 33136, United States