HEPATIC IMPAIRMENT

This study looks at how the drug MK-1084 (calderasib) moves through the body in people with liver problems compared to healthy people. About 58 adults will take a single dose, and researchers will measure drug levels and check for side effects. The goal is to understand if liver …

This early-stage study looks at how a single dose of the experimental drug combination bemnifosbuvir and ruzasvir is processed by the body in people with severe kidney or liver impairment compared to healthy volunteers. The goal is to gather safety and drug-level information, not…

This study looks at how a medicine called BI 3000202 is handled by the body in people with and without liver problems. About 44 adults aged 18 to 80 will take a single tablet and have their blood tested over a month. The goal is to understand if liver impairment changes drug leve…

This early-stage study looks at how the body processes the drug Saroglitazar in people with mild, moderate, or severe liver cirrhosis caused by cholestatic liver disease. About 30 adults aged 18 to 80 will take the drug once daily for 28 days. The goal is to measure drug levels a…

This study looks at how two experimental drugs (AZD9550 and AZD6234) behave in people with moderate to severe liver problems compared to healthy adults. About 28 participants will receive a single dose of one drug. The goal is to understand safety and how the liver processes thes…

This study looks at how the body processes a single dose of radiprodil in adults with mild, moderate, or severe liver problems compared to healthy adults. About 40 participants aged 18 to 75 will receive one 15 mg pill and be monitored for about 6 days. The goal is to see if live…

This study looks at how moderate or severe liver problems change the way the body handles a single dose of the drug inavolisib. About 32 adults with liver impairment and healthy volunteers will take part. The goal is to measure drug levels and safety, not to treat the liver condi…

This study looks at how the drug quizartinib is processed in people with severe liver problems compared to healthy people. About 12 adults will receive a single dose, and researchers will measure drug levels and side effects. The goal is to understand how liver impairment affects…

This study looks at how the drug mirdametinib is absorbed and removed from the body in people with moderate or severe liver problems compared to those with healthy livers. It involves 32 adults aged 18 to 80. The goal is to gather information, not to treat any condition.

This study looks at how different levels of liver function affect the way the body processes a new medicine called PF-07328948. Researchers will give a single tablet to 26 adults, some with liver problems and some healthy, and monitor them for about 6 days. The goal is to learn i…

This study looks at how mild or moderate liver problems change the way the body handles a single dose of the drug tasurgratinib. Researchers will compare 18 adults with stable liver impairment to healthy volunteers. The goal is to understand how the liver affects drug levels in t…

This study looks at how the body processes a new medicine called BI 1291583 in people with and without liver problems. The drug is being developed for bronchiectasis, a chronic lung disease. About 32 adults will take a single dose of the drug, and researchers will measure its lev…