New drug tested in people with liver disease – early safety check
NCT ID NCT07519135
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study is testing an investigational drug called PF-08653944 in 26 adults, some with healthy livers and others with mild to severe liver impairment. Researchers want to see how liver function affects the way the body processes the drug and whether it is safe. Participants receive a single injection and are monitored closely. The study is not expected to provide direct medical benefit but will guide future research.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PF-08653944 (also called MET097)
What this could lead to
If successful, this study could help determine safe dosing of PF-08653944 for people with liver disease.
What could go wrong
This is a very early Phase 1 study with only 26 participants. It is not designed to test if the drug works, only how it is processed and tolerated.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Floridian Clinical Research
RECRUITINGMiami Lakes, Florida, 33016, United States
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Genesis Clinical Research
RECRUITINGTampa, Florida, 33603, United States
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Orlando Clinical Research Center
RECRUITINGOrlando, Florida, 32809, United States