HEPATIC IMPAIRMENT

This study looked at how the body processes efinopegdutide, a potential drug for fatty liver disease, in people with moderate to severe liver damage compared to healthy people. A total of 22 adults received a single dose, and researchers measured drug levels and safety. The goal …

This study looked at how the experimental prostate cancer drug opevesostat (MK-5684) moves through the body in men with moderate liver impairment compared to healthy men. Sixteen male participants received a single dose, and researchers measured drug levels over time. The goal wa…

This study looked at how mild and moderate liver problems affect the way the body handles a single dose of the drug cenerimod. Researchers compared 24 adults—some with liver impairment and some healthy—to measure drug levels and safety. The goal was to gather information, not to …

This study looked at how the liver processes the drug bulevirtide in 74 people with either normal or impaired liver function. Researchers measured drug levels in the blood and how long it takes the body to clear it. The goal was to understand dosing needs for patients with liver …

This study looked at how the drug BPN14770 is handled by the body in people with different levels of liver impairment compared to healthy volunteers. 32 adults took a single dose, and researchers measured drug levels in the blood and checked for side effects. The goal was to unde…

This study looked at how the drug AZD2389 behaves in people with stable liver disease compared to healthy adults. Researchers gave a single dose to 35 participants and measured drug levels in the blood. The goal was to understand safety and how the liver affects drug processing, …

This study looked at how the body processes a single dose of the drug AMG 133 in 36 adults with mild, moderate, or severe liver problems compared to those with healthy livers. The goal was to see if liver function changes drug levels and safety. Results will help doctors decide t…

This study tested a single injection of a new medicine (NNC0194-0499) for fatty liver disease in 33 adults with various levels of liver function, including healthy volunteers. Researchers measured how the drug moves through the body and checked safety. The goal was to understand …

This study looked at how the body handles a single injection of fazirsiran in people with mild, moderate, or severe liver problems compared to those with healthy livers. A total of 34 participants received one shot and were followed for 6 months. The goal was to understand drug l…

This study looked at how the drug MK-8527 moves through the body in people with mild or moderate liver impairment compared to healthy volunteers. Researchers measured drug levels in the blood over time to understand how liver function affects the drug. The study involved 18 adult…

This study looked at how a single dose of the antifungal drug fosmanogepix is handled by the body in 28 adults with varying degrees of liver impairment. Participants took one pill, and researchers measured drug levels in the blood over time. The goal was to understand if liver fu…

This study tested a single dose of the drug AZD5004 in 33 adults with different levels of liver function (from normal to severe impairment). The goal was to see how the liver affects the drug levels in the blood and how safe it is. Results will help doctors decide the right dose …

This study looked at how the drug golcadomide is handled by the body in people with moderate or severe liver damage compared to healthy volunteers. 29 adults received a single dose to measure drug levels and check for side effects. The goal was to understand dosing needs for pati…

This study looked at how the drug ESK001 behaves in people with different levels of liver function. 32 adults with healthy livers or mild to severe liver impairment received a single dose. The goal was to measure drug levels and check for side effects, not to treat any condition.

This study looked at how the body processes cagrilintide, a drug being developed for weight management, in people with different levels of liver function. It involved 32 adults, including those with liver impairment and healthy volunteers. The goal was to measure drug levels in t…

This study looked at how a single dose of the drug repotrectinib stays in the blood of people with moderate or severe liver impairment compared to healthy volunteers. 18 adults participated, and researchers measured drug levels and checked for side effects. The goal was to unders…

This study looked at how the drug MCI-186 is processed in people with mild or moderate liver problems compared to healthy people. A total of 22 adults received a single dose of the drug through an IV. The goal was to see if liver function changes how the drug moves through the bo…

This study looked at how the drug evobrutinib is processed in people with different levels of liver function. 24 adults with either normal or impaired liver function received a single dose. The goal was to understand how liver health affects drug levels and safety.

This study looked at how moderate and severe liver impairment changes the way the body handles a single dose of the drug palovarotene. Researchers compared 31 participants with liver problems to healthy volunteers. The goal was to understand safety and drug levels in the blood, n…

This study looked at how the drug MK-8189 (elpipodect) behaves in people with mild or moderate liver problems compared to healthy people. Researchers measured drug levels in the blood and checked for side effects. The goal was to understand if liver impairment changes how the bod…

This early-phase study looked at how the drug nalbuphine extended-release is processed in people with mild, moderate, or severe liver problems compared to those with healthy livers. It also explored whether the drug could help relieve itching in participants who reported it. The …

This study looked at how the liver's health affects the way a drug called KP-001 moves through the body and its safety. It included 24 adults, some with liver problems and some healthy. Participants received a single dose of KP-001, and researchers measured drug levels in the blo…

This study looked at how the body handles a single dose of the experimental drug AZD2693 in people with liver impairment compared to healthy volunteers. Researchers measured drug levels in the blood to understand safety and processing differences. The study involved 35 adults and…

This study looked at how the body handles a single 50 mg dose of the drug ITF2357 in 24 adults with chronic liver impairment compared to those with normal liver function. The goal was to measure drug levels and safety, not to treat the liver condition. Participants took one oral …

This study looked at how the body processes a single dose of the drug divarasib in people with different levels of liver function. It included 31 adults with healthy livers or mild to severe liver problems. The goal was to measure drug levels in the blood and check for side effec…

This early-stage study aimed to understand how a single dose of an experimental drug called olpasiran is processed by the body in people with different levels of liver damage. It compared 25 participants with mild, moderate, or severe liver impairment to participants with normal …