Liver function may change how tirabrutinib acts in the body
NCT ID NCT07198087
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 1 study looked at how the drug tirabrutinib is processed in people with mild, moderate, or severe liver impairment compared to healthy volunteers. Forty participants took a single oral dose, and researchers measured drug levels and safety. The goal was to understand if liver problems affect how the drug behaves, which could guide future dosing recommendations.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tirabrutinib
What this could lead to
If successful, this study could help doctors decide the right dose of tirabrutinib for patients with liver problems, making treatment safer and more effective.
What could go wrong
This is an early-phase study focused on drug processing, not on treating the disease. Results may not directly improve patient outcomes, and liver impairment can affect drug safety unpredictably.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEPATIC IMPAIRMENT are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Arizona Liver Health
Chandler, Arizona, 85225, United States
-
Orlando Clinical Research Center, Inc.
Orlando, Florida, 32809, United States
-
Panax Clinical Research
Miami Lakes, Florida, 33014, United States