Liver function may change how tirabrutinib acts in the body
NCT ID NCT07198087
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 1 study looked at how the drug tirabrutinib is processed in people with mild, moderate, or severe liver impairment compared to healthy volunteers. Forty participants took a single oral dose, and researchers measured drug levels and safety. The goal was to understand if liver problems affect how the drug behaves, which could guide future dosing recommendations.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tirabrutinib
- What this could lead to
- If successful, this study could help doctors decide the right dose of tirabrutinib for patients with liver problems, making treatment safer and more effective.
- What could go wrong
- This is an early-phase study focused on drug processing, not on treating the disease. Results may not directly improve patient outcomes, and liver impairment can affect drug safety unpredictably.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Arizona Liver Health
Chandler, Arizona, 85225, United States
-
Orlando Clinical Research Center, Inc.
Orlando, Florida, 32809, United States
-
Panax Clinical Research
Miami Lakes, Florida, 33014, United States
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