Liver function may affect how body handles new antifungal drug
NCT ID NCT05582187
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how a single dose of the antifungal drug fosmanogepix is processed in the bodies of 28 adults with varying degrees of liver impairment. Participants took one pill by mouth, and researchers measured drug levels in the blood over time. The goal was to see if liver function changes how the drug is absorbed and cleared, which could help guide safe dosing for patients with liver problems.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fosmanogepix (a single oral dose)
What this could lead to
If successful, this study could help doctors determine the right dose of fosmanogepix for patients with liver problems, making the drug safer and more effective.
What could go wrong
This is a very early, small study (28 people) focused on drug processing, not on treating a disease. Results may not apply to real-world use, and side effects are possible.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Genesis Clinical Research, LLC
Tampa, Florida, 33603, United States
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Inland Empire Liver Foundation
Rialto, California, 92337, United States