New pill aims to slow lung scarring in IPF patients

NCT ID NCT07284459

Recruiting now Disease control Sponsor: Contineum Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 24, 2026 · Updated 14 times

Summary

This phase 2 trial tests an oral drug called PIPE-791 in 324 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Participants take either a low or high dose of PIPE-791 or a placebo daily for several months. The main goal is to see if the drug can slow the decline in lung function measured by forced vital capacity (FVC).

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PIPE-791 (oral tablet)
What this could lead to: If it works, this could point toward a new daily treatment to slow lung damage and help people with IPF breathe easier.
What could go wrong: This is a mid-stage trial with 324 people, so results are not final. The drug may not improve lung function or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis interstitial lung disease pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC PULMONARY FIBROSIS

Contacts and locations

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Study contacts

Contact

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Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Aotearoa Clinical Trials Trust - Middlemore Hospital - PPDS
RECRUITING

Papatoetoe, Auckland, 2025, New Zealand
Assuta Ashdod University Medical Center
RECRUITING

Ashdod, Southern District, 7747629, Israel
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Birmingham Heartlands Hospital
RECRUITING

Birmingham, B3 3HX, United Kingdom
Canterbury Respiratory Research Group
RECRUITING

Christchurch, Canterbury, 8001, New Zealand
Centre d'investigation Clinique Mauricie
RECRUITING

Trois-Rivières, Quebec, G8T 7A1, Canada
Centro Modelo de Cardiología-Laprida 554
RECRUITING

San Miguel de Tucumán, Tucumán Province, T4000IFL, Argentina
Centro Médico Dra de Salvo - Fundacion Respirar - PPDS
RECRUITING

Buenos Aires, C1426ABP, Argentina
Centro de Investigaciones Médicas Tucumán - PPDS
RECRUITING

San Miguel de Tucumán, Tucumán Province, T4000AXL, Argentina
Consultorios Médicos Organización del Buen Ayre SRL
RECRUITING

Buenos Aires, C1425FVH, Argentina
Dr. Anil Dhar Medicine Professional Corporation
RECRUITING

Windsor, Ontario, N8X 5A6, Canada
Dynamic Drug Advancement Ltd.
RECRUITING

Ajax, Ontario, L1S 2J5, Canada
Gachon University Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
Greenlane Clinical Centre
RECRUITING

Epsom, Auckland, 1051, New Zealand
Hadassah Medical Center- Ein Kerem - PPDS
RECRUITING

Jerusalem, Jerusalem, 9112001, Israel
Health New Zealand - Te Whatu Ora - Waikato Hospital
RECRUITING

Hamilton, Waikato Region, 3240, New Zealand
Hillel Yaffe Medical Center
RECRUITING

Hadera, Haifa District, 3820302, Israel
IPR-Investigaciones en Patologías Respiratorias
RECRUITING

San Miguel de Tucumán, Tucumán Province, T4000IAP, Argentina
IbaMedica
RECRUITING

Santa Fe, S3000ASF, Argentina
Institute for Respiratory Health
RECRUITING

Midland, Western Australia, 6056, Australia
Institute of Pulmonary Diseases of Vojvodina
RECRUITING

Kamenitz, Syrmia, 21204, Serbia
Instituto de Medicina Respiratoria - IMER
RECRUITING

Córdoba, X5003DCE, Argentina
Kaplan Medical Center
RECRUITING

Rehovot, Central District, 7661041, Israel
Korea University Anam Hospital
RECRUITING

Seoul, 2841, South Korea
Meir Medical Center
RECRUITING

Kafr Saba, Central District, 4428164, Israel
NIHR Leicester Biomedical Research Centre - Glenfield Hospital
RECRUITING

Leicester, England, LE3 9QP, United Kingdom
Perth Royal Infirmary
RECRUITING

Perth, Scotland, PH1 1NX, United Kingdom
Rabin Medical Center - PPDS
RECRUITING

Petah Tikva, Central District, 4941492, Israel
Royal Brompton Hospital
RECRUITING

London, SW3 6NP, United Kingdom
Royal Infirmary of Edinburgh
RECRUITING

Edinburgh, Scotland, EH16 4SA, United Kingdom
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
STAT Research S.A.
RECRUITING

Buenos Aires, C1023AAB, Argentina
Samsung Medical Center
RECRUITING

Seoul, Seoul, 06351, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Gyeonggi-do, 13620, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, Seodaemun, 03722, South Korea
Shaare Zedek Medical Center
RECRUITING

Jerusalem, Yerushala, 9103102, Israel
Shamir Medical Center
RECRUITING

Be’er Ya‘aqov, Central District, 7033001, Israel
Soon Chun Hyang University Hospital
RECRUITING

Seoul, Yongsan-gu, 04401, South Korea
Southampton General Hospital
RECRUITING

Southampton, Hampshire, SO16 6YD, United Kingdom
St Bartholomew's Hospital - PPDS
RECRUITING

London, Greater London, EC1A 7BE, United Kingdom
Tel Aviv Sourasky Medical Center Ichilov - PPDS
RECRUITING

Tel Aviv, 6423906, Israel
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Barzilai University Medical Center
RECRUITING

Ashkelon, Southern District, 7830604, Israel
The Catholic University of Korea - Eunpyeong St. Mary's Hospital
RECRUITING

Seoul, Eunpyeong District, 03312, South Korea
The Catholic University of Korea, Bucheon St. Mary's Hospital
RECRUITING

Bucheon-si, Gyeonggi-do, 14647, South Korea
The Chaim Sheba Medical Center - PPDS
RECRUITING

Ramat Gan, Central District, 5262100, Israel
The Prince Charles Hospital
RECRUITING

Chermside, Queensland, 4032, Australia
Toronto General Hospital
RECRUITING

Toronto, Ontaria, M5G 2C4, Canada
TrialsWest Pty Ltd
RECRUITING

Spearwood, Western Australia, 6163, Australia
University Clinical Center Kragujevac
RECRUITING

Kragujevac, 34000, Serbia
University Clinical Center of Serbia - Koste Todorovica - PPDS
RECRUITING

Belgrade, 11000, Serbia
Vancouver General Hospital
RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia

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