Can a simple kidney test help beat superbugs in the ICU?

NCT ID NCT06709521

Completed Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 5 times

Summary

This study aims to see if using a blood marker called Cystatin C can better predict how antibiotics work in critically ill ICU patients with drug-resistant infections. Researchers will compare Cystatin C to standard kidney function tests and a dye-based gold-standard test. The goal is to design dosing plans that are more accurate for each patient, potentially improving treatment success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Iohexol (a contrast dye used to measure kidney function), meropenem, cefepime
What this could lead to: If successful, this could lead to more precise antibiotic dosing for ICU patients, potentially improving treatment of resistant infections and reducing side effects.
What could go wrong: This is a Phase 4 study focused on measuring and modeling drug levels, not testing a new treatment. It may not directly improve patient outcomes, and results may not apply to all ICU settings.

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Conditions

The condition(s) this trial relates to.

bacterial infectious disease gram-negative bacterial infections

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BACTERIAL INFECTION

Contacts and locations

Locations

Carilion Roanoke Memorial Hospital

Roanoke, Virginia, 24014, United States
Corewell Health - Infectious Disease

Royal Oak, Michigan, 48073, United States
Duke University Hospital - Infectious Diseases

Durham, North Carolina, 27710, United States
East Carolina University - Infectious Diseases and Tropical/Travel Medicine Clinic

Greenville, North Carolina, 27834-9997, United States
Harbor UCLA Medical Center - Medicine - Infectious Diseases

Torrance, California, 90502-2006, United States
Henry Ford Health System - Henry Ford Hospital

Detroit, Michigan, 48202-2608, United States
Oregon Health and Science University - Adult Infectious Diseases Clinic

Portland, Oregon, 97239-3098, United States
Torrance Memorial Medical Center

Torrance, California, 90505, United States
University of Cincinnati College of Medicine - Division of Infectious Diseases

Cincinnati, Ohio, 45267, United States
University of Pittsburgh - Medicine - Infectious Diseases

Pittsburgh, Pennsylvania, 15213-3403, United States

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