Could a simple Self-Swap replace the speculum for cervical cancer screening?

NCT ID NCT07281430

Recruiting now Diagnosis Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study is testing whether self-collected vaginal samples for HPV testing work as well as samples collected by a doctor during a pelvic exam. The goal is to make cervical cancer screening more accessible and comfortable. About 500 people referred for colposcopy or cervical procedures will provide both a self-collected sample and a clinician-collected sample, and researchers will compare the accuracy of the HPV test results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HPV self-collection test
What this could lead to: If successful, this could make cervical cancer screening easier and more accessible by allowing people to collect their own samples at home.
What could go wrong: This is an early-stage study focused on accuracy, not on preventing cancer directly. The self-collection method may not be as reliable as clinician-collected samples.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical carcinoma human papilloma virus infection Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CARCINOMA HUMAN PAPILLOMAVIRUS INFECTION

Contacts and locations

Locations

Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Louisiana State University
RECRUITING

Lafayette, Louisiana, 70503, United States
Louisiana State University Health Science Center
RECRUITING

New Orleans, Louisiana, 70112, United States
Minneapolis VA Medical Center
RECRUITING

Minneapolis, Minnesota, 55417, United States
Montefiore Medical Center-Einstein Campus
RECRUITING

The Bronx, New York, 10461, United States
Montefiore Medical Center-Weiler Hospital
RECRUITING

The Bronx, New York, 10461, United States
UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UPMC-Magee Womens Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States
University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of Oklahoma
RECRUITING

Oklahoma City, Oklahoma, 73190, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania/Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
West Virginia University Healthcare
RECRUITING

Morgantown, West Virginia, 26506, United States

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