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Poop pills could protect gut after colon surgery – early trial begins

NCT ID NCT06692179

Recruiting now Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take the pill after surgery. Researchers will check if the donor bacteria take hold and improve gut health markers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
freeze-dried fecal microbiota (MTP-101P)
What this could lead to
If successful, this could pave the way for a simple pill to restore healthy gut bacteria after colon surgery, potentially reducing infections like C. diff.
What could go wrong
This is a very early Phase 1 trial with only 40 people, so safety and effectiveness are not yet proven. The treatment may not work or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Clostridium difficile colitis Clostridium infectious disease colorectal carcinoma diverticulitis polyp of colon

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLONIC SURGERY RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION

Contacts and locations

Locations

  • University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55414, United States

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