New HIV vaccine booster trial launches: could it strengthen immunity?

NCT ID NCT06665646

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial is testing a new HIV vaccine booster called VRIPRO, given with an immune-boosting adjuvant, in 40 healthy adults aged 18-60 who previously received an HIV vaccine in the HVTN 706 study. Participants will get three shots over 24 weeks. The main goals are to check safety and see if the booster increases HIV-fighting antibodies. This is a small, early study focused on safety and immune response, not on preventing HIV infection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CD40.HIVRI.Env (VRIPRO) vaccine with Hiltonol Poly-ICLC adjuvant
What this could lead to: If successful, this could point toward a more effective HIV vaccine strategy by boosting immune memory in people already vaccinated.
What could go wrong: This is a very early Phase 1 trial with only 40 participants, so it is primarily checking safety, not effectiveness. The immune response may be weak or not last, and side effects like injection site pain or flu-like symptoms are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV INFECTIONS

Contacts and locations

Locations

Bridge HIV CRS
RECRUITING

San Francisco, California, 94102, United States
Brigham and Women's Hospital Vaccine CRS (BWH VCRS)
RECRUITING

Boston, Massachusetts, 02115-6110, United States
Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales CRS (CITBM) - Unidad de Ensayos Clínicos (UNIDEC)
NOT_YET_RECRUITING

Bellavista, Provincia Constitucional del Callao, 07006, Peru
Columbia P&S CRS
WITHDRAWN

New York, New York, 10032, United States
Penn Prevention CRS (Site ID# 30310)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Seattle Vaccine and Prevention CRS
WITHDRAWN

Seattle, Washington, 98104, United States
The Hope Clinic of the Emory Vaccine Center CRS
WITHDRAWN

Decatur, Georgia, 30030, United States
Vanderbilt Vaccine (VV) CRS
RECRUITING

Nashville, Tennessee, 37232, United States
Via Libre CRS
NOT_YET_RECRUITING

Lima Cercado, Lima region, 15001, Peru

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