New hope for lung scarring: experimental drug MTX-463 enters Mid-Stage trial

NCT ID NCT06967805

Recruiting now Disease control Sponsor: Mediar Therapeutics Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 13, 2026 · Updated 23 times

Summary

This study tests an experimental drug called MTX-463 in 164 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. Participants will receive either the drug or a placebo to see if MTX-463 can slow the decline in lung function over 24 weeks. The trial also monitors safety and side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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São Bernardo do Campo, 09715, Brazil

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Abbotstown, D15 X40D, Ireland

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Ann Arbor, Michigan, 48209, United States

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Atlanta, Georgia, 30322, United States

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Baltimore, Maryland, 21224, United States

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Barcelona, 08017, Spain

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Barcelona, 08036, Spain

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Belo Horizonte, 30110, Brazil

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Birmingham, Alabama, 35233, United States

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Birmingham, B15 2GW, United Kingdom

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Boston, Massachusetts, 02114, United States

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Brussels, 1200, Belgium

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Buenos Aires, B1602DQD, Argentina

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Calgary, Alberta, T2N 4Z5, Canada

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Cambridge, CB2 0BB, United Kingdom

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Charleston, South Carolina, 29425, United States

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Córdoba, X5003DCE, Argentina

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Curitiba, 80060, Brazil

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Denver, Colorado, 80206, United States

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Detroit, Michigan, 48202, United States

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Drogheda, F92VW28, Ireland

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Dublin, D24 NR0A, Ireland

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Durham, North Carolina, 27710, United States

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Edegem, 2650, Belgium

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Edinburgh, EH16 4SA, United Kingdom

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Letterkenny, F92 AE81, Ireland

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Los Angeles, California, 90033, United States

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Louisville, Kentucky, 40202, United States

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Lugo, 27003, Spain

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Madrid, 28223, Spain

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Madrid, 28050, Spain

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Mendoza, M5500, Argentina

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Nantes, 44800, France

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Nashville, Tennessee, 37204, United States

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Nice, 06001, France

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Nieuwegein, 3435CM, Netherlands

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Oxford, OX3 7LE, United Kingdom

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Palm Springs, California, 92203, United States

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Paris, 75015, France

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Passo Fundo, 99010, Brazil

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Pittsburgh, Pennsylvania, 15213, United States

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Porto Alegre, 90035, Brazil

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Porto Alegre, 90410, Brazil

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Rennes, 35033, France

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Rosario, S2000DBS, Argentina

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Salt Lake City, Utah, 84103, United States

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San Miguel de Tucumán, T4000IAI, Argentina

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Santa Fe, S2000DBS, Argentina

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Santa Fe, S3000ASF, Argentina

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Santander, 39008, Spain

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São Paulo, 05403, Brazil

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Split, 21000, Croatia

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Milwaukee, Wisconsin, 52226, United States

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Ajax, Ontario, L1S 2J5, Canada

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Champaign, Illinois, 61822, United States

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Dallas, Texas, 75204, United States

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Greensboro, North Carolina, 27403, United States

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Greenslopes, 4120, Australia

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Kansas City, Kansas, 66160, United States

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Loxahatchee Groves, Florida, 33470, United States

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Melbourne, 3004, Australia

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Midland, 6056, Australia

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New York, New York, 10032, United States

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Newport Beach, California, 92663, United States

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Oklahoma City, Oklahoma, 73104, United States

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Phoenix, Arizona, 85032, United States

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Shreveport, Louisiana, 71103, United States

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Trois-Rivières, Quebec, G8T 7A1, Canada

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WISPer site in Westmead, Australia
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Westmead, 2145, Australia

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Conditions

Explore the condition pages connected to this study.

IDIOPATHIC PULMONARY FIBROSIS