New antibody drug aims to slow lung scarring in IPF

NCT ID NCT06967805

Recruiting now Disease control Sponsor: Mediar Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This phase 2 trial tests whether MTX-463, an antibody that blocks a protein linked to scarring, can slow lung function decline in people with idiopathic pulmonary fibrosis (IPF). About 164 adults with IPF will receive either the drug or a placebo for 24 weeks. The main goal is to see if the drug improves forced vital capacity, a measure of lung function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MTX-463 (a monoclonal antibody)
What this could lead to: If successful, this could point toward a new treatment to slow lung function decline in people with idiopathic pulmonary fibrosis.
What could go wrong: This is an early phase 2 trial with only 164 participants, so results may not confirm effectiveness. The drug may cause side effects or fail to improve breathing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Fibrosis idiopathic pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC PULMONARY FIBROSIS

Contacts and locations

Locations

WISP Site in São Bernardo Do Campo, Brazil
RECRUITING

São Bernardo do Campo, 09715, Brazil
WISPer Site in Abbotstown, Ireland
RECRUITING

Abbotstown, D15 X40D, Ireland
WISPer Site in Ann Arbor, MI
RECRUITING

Ann Arbor, Michigan, 48209, United States
WISPer Site in Atlanta, GA
RECRUITING

Atlanta, Georgia, 30322, United States
WISPer Site in Baltimore, MD
RECRUITING

Baltimore, Maryland, 21224, United States
WISPer Site in Barcelona, Spain
RECRUITING

Barcelona, 08017, Spain
WISPer Site in Barcelona, Spain
RECRUITING

Barcelona, 08036, Spain
WISPer Site in Barcelona, Spain
RECRUITING

Barcelona, 08908, Spain
WISPer Site in Belo Horizonte, Brazil
RECRUITING

Belo Horizonte, 30110, Brazil
WISPer Site in Birmingham, AL
RECRUITING

Birmingham, Alabama, 35233, United States
WISPer Site in Birmingham, UK
RECRUITING

Birmingham, B15 2GW, United Kingdom
WISPer Site in Boston, MA
RECRUITING

Boston, Massachusetts, 02114, United States
WISPer Site in Brussels, Belgium
RECRUITING

Brussels, 1200, Belgium
WISPer Site in Buenos Aires, Argentina
RECRUITING

Buenos Aires, B1602DQD, Argentina
WISPer Site in Calgary, Alberta
RECRUITING

Calgary, Alberta, T2N 4Z5, Canada
WISPer Site in Cambridge, UK
RECRUITING

Cambridge, CB2 0BB, United Kingdom
WISPer Site in Charleston, SC
RECRUITING

Charleston, South Carolina, 29425, United States
WISPer Site in Cordoba, Argentina
RECRUITING

Córdoba, X5003DCE, Argentina
WISPer Site in Curitiba, Brazil
RECRUITING

Curitiba, 80060, Brazil
WISPer Site in Denver, CO
RECRUITING

Denver, Colorado, 80206, United States
WISPer Site in Detroit, MI
RECRUITING

Detroit, Michigan, 48202, United States
WISPer Site in Drogheda, Ireland
RECRUITING

Drogheda, F92VW28, Ireland
WISPer Site in Dublin, Ireland
RECRUITING

Dublin, D24 NR0A, Ireland
WISPer Site in Durham, NC
RECRUITING

Durham, North Carolina, 27710, United States
WISPer Site in Edegem, Belgium
RECRUITING

Edegem, 2650, Belgium
WISPer Site in Edinburgh, UK
RECRUITING

Edinburgh, EH16 4SA, United Kingdom
WISPer Site in Letterkenny, Ireland
RECRUITING

Letterkenny, F92 AE81, Ireland
WISPer Site in Los Angeles, CA
RECRUITING

Los Angeles, California, 90033, United States
WISPer Site in Louisville, KY
RECRUITING

Louisville, Kentucky, 40202, United States
WISPer Site in Lugo, Spain
RECRUITING

Lugo, 27003, Spain
WISPer Site in Madrid, Spain
RECRUITING

Madrid, 28223, Spain
WISPer Site in Madrid, Spain 2
RECRUITING

Madrid, 28050, Spain
WISPer Site in Mendoza, Argentina
RECRUITING

Mendoza, M5500, Argentina
WISPer Site in Nantes, France
RECRUITING

Nantes, 44800, France
WISPer Site in Nashville, TN
RECRUITING

Nashville, Tennessee, 37204, United States
WISPer Site in Nice, France
RECRUITING

Nice, 06001, France
WISPer Site in Nieuwegein, Netherlands
RECRUITING

Nieuwegein, 3435CM, Netherlands
WISPer Site in Oxford, UK
RECRUITING

Oxford, OX3 7LE, United Kingdom
WISPer Site in Palm Springs, CA
RECRUITING

Palm Springs, California, 92203, United States
WISPer Site in Paris, France
RECRUITING

Paris, 75015, France
WISPer Site in Passo Fundo, Brazil
RECRUITING

Passo Fundo, 99010, Brazil
WISPer Site in Pittsburg, PA
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
WISPer Site in Porto Alegre, Brazil
RECRUITING

Porto Alegre, 90035, Brazil
WISPer Site in Porto Alegre, Brazil
RECRUITING

Porto Alegre, 90410, Brazil
WISPer Site in Rennes, France
RECRUITING

Rennes, 35033, France
WISPer Site in Rosario, Argentina
RECRUITING

Rosario, S2000DBS, Argentina
WISPer Site in Rotterdam, Netherlands
RECRUITING

Rotterdam, 3015, Netherlands
WISPer Site in Salt Lake City, UT
RECRUITING

Salt Lake City, Utah, 84103, United States
WISPer Site in San Miguel De Tucumán, Argentina
RECRUITING

San Miguel de Tucumán, T4000IAI, Argentina
WISPer Site in Santa Fe, Argentina
RECRUITING

Santa Fe, S2000DBS, Argentina
WISPer Site in Santa Fe, Argentina
RECRUITING

Santa Fe, S3000ASF, Argentina
WISPer Site in Santander, Spain
RECRUITING

Santander, 39008, Spain
WISPer Site in Sao Paulo, Brazil
RECRUITING

São Paulo, 05403, Brazil
WISPer Site in Split
RECRUITING

Split, 21000, Croatia
WISPer Site in Wilwaukee, WI
RECRUITING

Milwaukee, Wisconsin, 52226, United States
WISPer site in Ajax, ON
RECRUITING

Ajax, Ontario, L1S 2J5, Canada
WISPer site in Champaign, IL
RECRUITING

Champaign, Illinois, 61822, United States
WISPer site in Dallas, TX
RECRUITING

Dallas, Texas, 75204, United States
WISPer site in Greensboro, NC
RECRUITING

Greensboro, North Carolina, 27403, United States
WISPer site in Greenslopes, Australia
RECRUITING

Greenslopes, 4120, Australia
WISPer site in Kansas City, KS
RECRUITING

Kansas City, Kansas, 66160, United States
WISPer site in Loxahatchee, FL
RECRUITING

Loxahatchee Groves, Florida, 33470, United States
WISPer site in Melbourne, Australia
RECRUITING

Melbourne, 3004, Australia
WISPer site in Midland, Australia
RECRUITING

Midland, 6056, Australia
WISPer site in New York, NY
RECRUITING

New York, New York, 10032, United States
WISPer site in Newport Beach, CA
RECRUITING

Newport Beach, California, 92663, United States
WISPer site in Oklahoma City, OK
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
WISPer site in Phoenix, AZ
RECRUITING

Phoenix, Arizona, 85032, United States
WISPer site in Shreveport, LA
RECRUITING

Shreveport, Louisiana, 71103, United States
WISPer site in Trois-Rivières, Quebec
RECRUITING

Trois-Rivières, Quebec, G8T 7A1, Canada
WISPer site in Westmead, Australia
RECRUITING

Westmead, 2145, Australia

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