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Sugar tracer reveals how immune cells fuel up in the ICU

NCT ID NCT07811180

Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
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The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers at Vanderbilt University Medical Center want to understand how immune cells use glucose, the body's main sugar, during critical illness. They give 25 adult ICU patients an intravenous infusion of a non-radioactive carbon-13 glucose tracer over a few hours. Then they collect immune cells from blood samples and measure how much tracer the cells took up and what they did with it. The goal is to map immune cell metabolism in conditions like sepsis, which could inform future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
carbon-13 labeled glucose tracer
What this could lead to
If researchers map how immune cells burn glucose during critical illness, that could point to new ways to support the immune system in ICU patients with sepsis or other severe conditions.
What could go wrong
This is a small observational tracer study with 25 ICU patients, so it can only describe glucose use, not prove that changing it helps anyone. The findings may not apply to other patient groups or illnesses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 or older * Admitted to one of the following VUMC adult ICUs: Medical ICU, Pulmonary ICU * The participant or legally authorized representative must agree to the genetic analyses required as part of this study Exclusion Criteria: * Pregnant * Prisoner or in police custody * Patient desires comfort measures only or has a goals-of-care plan inconsistent with participation in non-beneficial research procedures * Hemoglobin less than 8 g/dL * Uncontrolled hyperglycemia (persistent blood glucose \>300 mg/dL) or any clinical condition in which additional IV glucose administration is not appropriate in the opinion of the Study Coordinator, PI, or treating ICU team * Current participation in another study where the total volume of blood drawn, when added to this study blood draw volume, exceeds 500 mL in an 8-week period * Unable to safely obtain vascular access required for study infusion and blood collection * Clinical instability or anticipated clinical care needs that would make the study procedure inappropriate at that time in the opinion of the Study Coordinator, PI, or treating ICU team * Any medical issue or pharmacologic exposure which, in the opinion of the study investigator, might interfere with the study objectives * Any reason which, in the opinion of the study investigator, adds additional risk to the patient

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Conditions

The condition(s) this trial relates to.

adult acute respiratory distress syndrome Critical Illness immune system disorder infectious disease with sepsis metabolic disease Sepsis toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Glucose Immune system and related disorders Intensive care unit (ICU) Isotope labeling Metabolism Sepsis

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37212, United States

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