Necrotizing soft tissue infection

This study tests whether adding hyperbaric oxygen treatment (breathing pure oxygen in a pressurized chamber) to standard care can lower the death rate in people with severe, fast-spreading soft-tissue infections. About 1,480 adults with surgically confirmed infection will be rand…

This study tests a special wound dressing made from pig tissue (Cytal Wound Matrix and MicroMatrix) to see if it helps heal wounds from necrotizing fasciitis (a severe flesh-eating infection) faster than standard dressings. Fifty adults with large wounds (at least 30 cm²) will be…

This study compares a 48-hour course of antibiotics to a standard 7-day course for people with severe, life-threatening skin infections called necrotizing soft tissue infections. Researchers want to see if the shorter treatment is just as safe and effective. The trial will enroll…

This study tests two types of wound vacuum therapy for people with severe, flesh-eating infections. One method just uses suction, while the other also cleans the wound with a dilute bleach solution. Researchers want to see if the cleaning method leads to fewer hospital readmissio…

This study tests whether a safe, FDA-approved dye called indocyanine green (ICG) can help doctors quickly tell the difference between a life-threatening flesh-eating infection (necrotizing fasciitis) and a less dangerous skin infection. About 420 adults with suspected infections …

This study tests whether exposure to bright blue light can reduce inflammation and organ damage in people hospitalized with serious infections like pneumonia, infected joints, or abdominal infections. Participants will be randomly assigned to receive either blue-enriched light or…

This observational study follows 800 adults who receive Myriad™ during soft tissue reconstruction for wounds like abdominal dehiscence, pressure injuries, or anal fistulas. Researchers track healing time, complications, and side effects to understand how well the material works i…

This study looks at 300 adults hospitalized with rare but life-threatening flesh-eating infections (necrotizing soft tissue infections). Researchers want to find out which early signs and routine lab tests can predict who is most likely to die during their hospital stay. The goal…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than only seeing a doctor when needed. About 2,674 children hospitalized for pneumonia, urinary tract infections, skin infections, or stomach bugs will take part. T…