Could a 'Vaginal microbiome Transplant' stop recurring BV?
NCT ID NCT07566754
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether transferring vaginal fluid from healthy donors can help women aged 18-25 with recurrent bacterial vaginosis (BV). Participants first receive standard antibiotics, then the transplant. The goal is to see if this restores a healthy vaginal microbiome and prevents BV from coming back.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Vaginal microbiome transplantation (VMT) from healthy donors, plus oral metronidazole
- What this could lead to
- If it works, this could offer a new way to restore healthy vaginal bacteria and reduce repeat infections for women with recurrent bacterial vaginosis.
- What could go wrong
- This is a small, early-phase trial (75 people) testing a novel biological treatment. It may not work for everyone, and long-term safety and effectiveness are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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FRESH Clinic
Durban, South Africa