Can a Weight-Loss drug also calm a painful skin disease?
NCT ID NCT07830329
First seen Sep 21, 2026 · Last updated Sep 21, 2026
Summary
Researchers are testing an experimental drug called olatorepatide in adults with moderate to severe hidradenitis suppurativa who also live with overweight or obesity. Hidradenitis suppurativa causes painful lumps and tunnels under the skin. The trial compares olatorepatide with a placebo over 52 weeks to see whether the drug reduces abscesses and inflammatory nodules, eases skin pain, and supports weight loss. About 300 participants will take part, and researchers will also track side effects and how the body processes the drug.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- an experimental drug called olatorepatide, a GLP-1/GIP receptor agonist
- What this could lead to
- If it works, olatorepatide could become a new way to reduce hidradenitis suppurativa flare-ups and support weight loss in people living with both conditions.
- What could go wrong
- This is a mid-stage trial, so researchers do not yet know if olatorepatide helps hidradenitis suppurativa or whether benefits outweigh side effects. GLP-1/GIP drugs commonly cause nausea, vomiting, and diarrhea, and some people may develop antibodies that make the drug less effective.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 300 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Key Inclusion Criteria: 1. Diagnosis of HS based on: 1. Documented or reported history of HS for ≥6 months prior to baseline visit 2. Confirmation of HS by the investigator during physical examination at screening 2. HS lesions present in at least 2 distinct anatomic areas as described in the protocol 3. Moderate to severe HS, defined as a total of ≥5 inflammatory lesions (ie, number of abscesses plus number of inflammatory nodules) at both screening (visit 1) and baseline (visit 2) 4. Agree to daily use of over-the-counter topical antiseptics (eg, chlorhexidine gluconate, benzoyl peroxide, or diluted bleach \[bath\], or alternative antiseptic agents in accordance with local/country guidelines) applied to HS-affected areas as described in the protocol 5. Body Mass Index (BMI) ≥27.0 kg/m2 at screening Key Exclusion Criteria: 1. Has a sensitivity (or history of hypersensitivity reactions) to any of the trial interventions, or components thereof, or other allergy that, in the opinion of the investigator or medical monitor, contraindicates participation in the trial 2. Cardiovascular or cerebrovascular events or procedures within 90 days prior to screening, including myocardial infarction, hospitalization for unstable angina, coronary artery bypass graft, percutaneous coronary intervention as described in the protocol 3. Current heart failure classified as being in NYHA Class IV at screening 4. History of chronic pancreatitis or acute pancreatitis 5. Presence of serious Gastrointestinal (GI) disorders (eg, active peptic ulcer, inflammatory bowel disease) at screening 6. Have a previous or current diagnosis of Type 1 Diabetes (T1D) or any other type of diabetes except Type 2 Diabetes (T2D) as described in the protocol Note: Other Protocol Defined Inclusion/ Exclusion Criteria Apply
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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