Abscess

This trial compares two oral antibiotics—trimethoprim-sulfamethoxazole (TMP-SMX) and clindamycin—to see which works better for children with invasive MRSA infections, such as bone, joint, or deep tissue infections. About 100 children aged 60 days to 18 years will take one of the …

This study looks at whether placing a small tube through the chest wall to drain pus from a lung abscess, along with standard antibiotics, helps people recover faster and leave the hospital earlier. About 84 adults with large abscesses will be randomly assigned to get either the …

This study tests a device called IRRAflow that continuously washes out blood from the brain after a hemorrhage. It involves 250 adults with brain bleeds and compares the device to standard drainage. The goal is to see if it clears blood faster and improves recovery at 6 months.

This study compares two ways to diagnose a peritonsillar abscess (a pus pocket near the tonsils): the usual physical exam versus adding a small ultrasound probe inside the mouth. About 368 adults with suspected abscess will take part. The goal is to see if ultrasound improves acc…

This study is testing advanced lab techniques, like genetic sequencing and multiplex PCR, to improve how doctors diagnose complex eye infections such as endophthalmitis and severe corneal abscesses. Researchers will compare the new methods to standard cultures to see if they find…

This study tests whether a ketamine nasal spray, given alongside standard numbing medicine, can lower pain during minor procedures like stitching cuts or draining abscesses in the emergency department. About 108 adults and children (ages 7 to under 70) will be randomly assigned t…

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study watches over 1000 adults having laparoscopic appendix removal to see if washing the belly with fluid (lavage) reduces the chance of internal infections. Doctors will note how dirty the belly is and decide on washing based on a new classification system. The goal is to …

This study looks at the gut bacteria of 3000 adults with chronic liver diseases like autoimmune hepatitis and fatty liver. Researchers want to find specific bacteria linked to each disease to better understand how the gut and liver interact. This is an observational study, not a …

This study follows 200 people treated for a spinal infection called spinal epidural abscess. Researchers want to see if things like employment, income, insurance, and housing are linked to whether the infection comes back within a year. No new treatments are tested; the goal is t…

This study looks at whether packing a skin abscess after draining it is really needed. About 196 adults who need an abscess drained will be followed to see if skipping packing leads to more infections, extra procedures, or hospital visits. The goal is to find out if the common pr…

This study is a registry that collects information from 520 patients diagnosed with central nervous system (CNS) infections, such as meningitis or encephalitis. Researchers will track how many patients survive to discharge. The goal is to better understand these rare but serious …