Abscess

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests whether adding a light-activated blue dye treatment to standard abscess drainage can clear infection faster. About 120 adults with deep abscesses will get either standard drainage alone or drainage plus the dye treatment. The main goal is to see if the dye treatm…

This study tests a minimally invasive laparoscopic procedure to drain pyogenic liver abscesses in 30 adults who cannot have standard drainage. The goal is to see if it leads to fewer complications, faster recovery, and lower recurrence compared to open surgery or needle drainage.

This phase 2 study tests whether adding methylene blue photodynamic therapy (MB-PDT) to standard drainage helps breast abscesses heal faster. Fifty adults with breast abscesses will either receive standard drainage alone or drainage plus MB-PDT. The main goal is to see how quickl…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This observational study will follow 50 patients with primary spondylodiscitis, a serious spinal infection, for one year. Researchers will track cure rates, pain levels, and daily function using standard treatments like antibiotics and braces. The goal is to understand how well c…

This study explores whether a blood test can identify the bacteria causing a brain abscess, potentially avoiding the need for brain surgery to get a sample. Researchers will compare the germs found in the blood with those found in the abscess during surgery in 15 adults. If succe…

This study will follow 75 adults who need root canal treatment or retreatment at a hospital dental clinic in Rome. Researchers will check how well the teeth heal using X-rays and symptom reports over up to 5 years. The goal is to understand success rates and how factors like over…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at two different sizes of double-lumen breathing tubes used during lung surgery. It aims to see if a smaller 35 Fr tube is easier to insert, keeps oxygen levels stable, and causes less sore throat afterward. About 60 adults having lung surgery will take part, and…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…