Abscess

This study looks at whether placing a small tube through the chest wall to drain pus from a lung abscess, along with standard antibiotics, helps people recover faster and leave the hospital earlier. About 84 adults with large abscesses will be randomly assigned to get either the …

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study tests a device called IRRAflow that continuously washes out blood from the brain after a hemorrhage. It involves 250 adults with brain bleeds and compares the device to standard drainage. The goal is to see if it clears blood faster and improves recovery at 6 months.

This study compares two ways to diagnose a peritonsillar abscess (a pus pocket near the tonsils): the usual physical exam versus adding a small ultrasound probe inside the mouth. About 368 adults with suspected abscess will take part. The goal is to see if ultrasound improves acc…

This study is testing advanced lab techniques, like genetic sequencing and multiplex PCR, to improve how doctors diagnose complex eye infections such as endophthalmitis and severe corneal abscesses. Researchers will compare the new methods to standard cultures to see if they find…

This study tests whether a ketamine nasal spray, given alongside standard numbing medicine, can lower pain during minor procedures like stitching cuts or draining abscesses in the emergency department. About 108 adults and children (ages 7 to under 70) will be randomly assigned t…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study watches over 1000 adults having laparoscopic appendix removal to see if washing the belly with fluid (lavage) reduces the chance of internal infections. Doctors will note how dirty the belly is and decide on washing based on a new classification system. The goal is to …

This study looks at the gut bacteria of 3000 adults with chronic liver diseases like autoimmune hepatitis and fatty liver. Researchers want to find specific bacteria linked to each disease to better understand how the gut and liver interact. This is an observational study, not a …

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study follows 200 people treated for a spinal infection called spinal epidural abscess. Researchers want to see if things like employment, income, insurance, and housing are linked to whether the infection comes back within a year. No new treatments are tested; the goal is t…

This study looks at whether packing a skin abscess after draining it is really needed. About 196 adults who need an abscess drained will be followed to see if skipping packing leads to more infections, extra procedures, or hospital visits. The goal is to find out if the common pr…

This study is a registry that collects information from 520 patients diagnosed with central nervous system (CNS) infections, such as meningitis or encephalitis. Researchers will track how many patients survive to discharge. The goal is to better understand these rare but serious …

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…