Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can saliva reveal the secrets of long COVID?

NCT ID NCT07781501

Knowledge-focused Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This study aims to understand why some people develop Long COVID—persistent symptoms after a COVID-19 infection—by tracking symptoms over time and analyzing saliva samples. Researchers will follow 500 adults aged 18 to 75 who have previously tested positive for SARS-CoV-2, collecting health questionnaires and non-invasive oral samples. The goal is to identify biological factors in saliva that may be linked to persistent symptoms and help predict who is more likely to experience Long COVID.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify biological markers in saliva that predict who is more likely to develop Long COVID, potentially guiding earlier interventions.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not apply to everyone, and the biological markers identified may not be definitive predictors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 18 to 75 years with a history of SARS-CoV-2 infection will be enrolled. The study will include individuals with and without persistent symptoms following infection to characterize the prevalence, severity, and persistence of PASC and identify demographic, clinical, and biological factors associated with Long COVID. Approximately 500 participants will be enrolled at the University of North Carolina at Chapel Hill.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 75 years. * Previous laboratory-confirmed SARS-CoV-2 infection. * Willing and able to provide informed consent. * Able to complete study questionnaires and study procedures. Exclusion Criteria: * Current severe periodontal disease with bleeding gums. * Current oral herpes flare, aphthous ulcer, or oral candidiasis (thrush). * Oral viral or bacterial infection within the previous 30 days. * Dry mouth that would prevent adequate saliva collection. * Active alcohol or drug abuse. * Medical or genetic syndrome or developmental delay that would prevent completion of study procedures or questionnaires.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SARS CoV-2 post-acute sequelae are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

COVID-19 long COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SARS CoV-2 post-acute sequelae

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27599-7555, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.