Can vaginal estradiol or moisturizer ease menopause symptoms in women with HIV?
NCT ID NCT07526948
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares vaginal estradiol tablets (Vagifem) to a vaginal moisturizer (Replens) for treating menopause-related vaginal and urinary symptoms in women living with HIV. Researchers will also check how these treatments affect the vaginal microbiome. The study includes 62 participants, some with HIV and some without, and lasts 16 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vaginal estradiol (Vagifem) and vaginal moisturizer (Replens)
What this could lead to
If it works, this could point toward a safe way to ease menopause symptoms and improve vaginal health in women living with HIV.
What could go wrong
This is a small, early-phase study with only 62 participants. Results may not apply to all women, and the benefits of estradiol or moisturizer may be modest.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HIV - HUMAN IMMUNODEFICIENCY VIRUS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Albert Einstein College of Medicine
The Bronx, New York, 10461, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••