Can vaginal estradiol or moisturizer ease menopause symptoms in women with HIV?
NCT ID NCT07526948
First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 3 times
Summary
This study compares vaginal estradiol tablets (Vagifem) to a vaginal moisturizer (Replens) for treating menopause-related vaginal and urinary symptoms in women living with HIV. Researchers will also check how these treatments affect the vaginal microbiome. The study includes 62 participants, some with HIV and some without, and lasts 16 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- vaginal estradiol (Vagifem) and vaginal moisturizer (Replens)
- What this could lead to
- If it works, this could point toward a safe way to ease menopause symptoms and improve vaginal health in women living with HIV.
- What could go wrong
- This is a small, early-phase study with only 62 participants. Results may not apply to all women, and the benefits of estradiol or moisturizer may be modest.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Albert Einstein College of Medicine
The Bronx, New York, 10461, United States
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