Vaginitis

This study compares two oral treatments for trichomonas, a common sexually transmitted infection. About 1,200 women and men with a positive test will receive either a single dose of secnidazole or multiple doses of metronidazole over several days. The goal is to see which approac…

This study tests a new gel called OCF001 for treating acute yeast infections in women. About 36 women with a confirmed yeast infection will use the gel or a placebo for 7 days. Researchers will check if the infection clears up and if the gel is safe and well-tolerated.

This study tests whether boric acid vaginal inserts (600 mg) taken for 7 or 14 days can safely and effectively treat yeast infections. About 400 women aged 12 and older with active symptoms will participate. The goal is to see if all signs and symptoms disappear without needing m…

This study tests whether lactoferrin, a natural prebiotic from cow's milk, can be a good alternative to antibiotic tablets for women with bacterial vaginosis (BV) or thrush. Researchers will recruit 114 women and give half lactoferrin vaginal pessaries for 3 weeks, while the othe…

This early study tests whether a lactic acid gel (Phexxi) used twice weekly can change the vaginal microbiome to help prevent recurrent bacterial vaginosis and yeast infections. 22 premenopausal women with a history of these infections will use the gel for 4 weeks. Researchers wi…

This study is testing a new cooling device placed in the vagina to treat yeast infections. Researchers want to see if it can relieve symptoms and clear the infection within 7 days. The study involves 55 women aged 22-49 with uncomplicated yeast infections. It is an early-stage tr…

This study tests a gel device called Multi-Gyn FemiTotal in 80 women with bacterial vaginosis or vaginal yeast infections. Participants use the gel for 7 days, and if symptoms clear, they are followed for 4 months to see if the infection returns. The goal is to see if the gel can…

This study tests whether a gel called Multi-Gyn ActiGel Plus can effectively treat bacterial vaginosis, a common vaginal infection. About 200 women will use the gel or a placebo twice daily for one week. Researchers will check if the infection is gone three weeks after starting t…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study tests whether a vaginal testosterone cream can prevent repeat urinary tract infections (UTIs) in postmenopausal women aged 60-90 who have had at least three UTIs. Participants will apply the cream or a placebo for 9 months and be monitored for infections. The goal is t…

This study tests a vaginal tablet called AZU-101 (lasofoxifene) in 90 postmenopausal women aged 45-60 who have vaginal atrophy, causing dryness and pain during sex. The tablet is given daily for 14 days to see if it is safe and can improve vaginal cell health and lower vaginal pH…

This study tests whether adding a probiotic supplement (Bioithas WOMAN®) to standard antifungal medicine helps relieve symptoms of vaginal yeast infections faster. About 60 women with suspected yeast infections will take either antifungal treatment alone or with the probiotic for…

This study tests a laser treatment for vaginal dryness in breast cancer survivors. Many survivors experience this side effect from cancer treatments like chemotherapy or hormone therapy. The trial will compare the laser to no treatment in 250 women to see if it improves symptoms.

This study tests whether adding a special laser treatment to a standard estrogen cream works better than the cream alone for postmenopausal women with vaginal dryness, burning, or pain during sex. Sixty women aged 45–70 will be randomly assigned to receive either a real or sham l…

This study tests a new hormone-free gel for women with genitourinary syndrome of menopause (GSM), which causes vaginal dryness, pain, and other symptoms. About 80 postmenopausal women will use the gel for 8 weeks. Researchers will measure changes in quality of life using a questi…

This study tests if a procedure called vaginal radiofrequency can help reduce vaginal dryness in women being treated for breast cancer. The trial will include 75 women who are on hormone therapy and still have dryness despite using moisturizers. Half will continue with standard h…

This study tests whether a vaginal estrogen cream (Imvexxy) can improve sexual function in breastfeeding women who are 6 weeks to 6 months postpartum. About 100 participants will either use the estrogen cream or a placebo-like vitamin E suppository for 12 weeks. The goal is to se…

This study compares a silicone gel (StrataMGT) to standard estrogen cream for treating genitourinary syndrome of menopause, which causes vaginal dryness and irritation. About 100 postmenopausal women will use one of the treatments for three months. Researchers will check if the g…

This study is testing a new gel dressing for women with vaginal atrophy, lichen sclerosus, or similar vulvar skin conditions. About 2000 adult women will use the gel and report their symptoms and quality of life over 12 months. The goal is to see if the gel safely reduces discomf…

This study tests a non-hormonal laser treatment for vaginal dryness, burning, and pain during sex caused by menopause. About 50 postmenopausal women will either receive the real laser or a sham (fake) treatment. Researchers will use a special camera to measure changes in vaginal …

This study is testing whether a daily cream (7-0940®) can safely improve symptoms of vaginal atrophy in 10 women who have already completed laser therapy. Researchers will check vaginal health, quality of life, and any side effects over 45 days. The goal is to see if the cream he…

This study tests whether a non-surgical radiofrequency device, combined with pelvic floor exercises, can reduce vaginal dryness and other menopause-related symptoms in breast cancer survivors. Fifty women will receive either active or sham radiofrequency once a week for six weeks…

This study looks at how common and severe menopause-like symptoms (like vaginal dryness and pain) are in breast cancer survivors compared to healthy women. Researchers will ask 264 women to fill out questionnaires about their symptoms, quality of life, and mental health. The goal…

This study looks at how different menstrual products—tampons, cups, and pads—affect the bacteria and immune cells in the vagina. Researchers will collect samples from 300 women aged 18-49 to compare these groups. The goal is to understand if internal products like tampons and cup…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study is creating a huge collection of ultrasound images from the uterus and ovaries. Researchers will gather scans from 25,000 women, both healthy and with gynecological conditions, during routine checkups. The goal is to build a database that doctors and artificial intelli…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study is creating a data bank to better understand vaginal conditions like vulvodynia, yeast infections, bacterial vaginosis, and preterm labor. Researchers will look at proteins, immune markers, and vaginal bacteria in 550 women, including healthy volunteers and those with …

This study checks if having a vaginal infection before vulvar surgery raises the risk of wound infections or breakdown. About 91 adults with non-cancerous vulvar conditions will be tested with a swab on surgery day. Researchers will follow up by phone at 1 week and a clinic visit…

This study looks at whether vaginal estrogen tablets, used to treat vaginal atrophy, change blood clotting factors in postmenopausal women. Researchers will take blood samples before and after 3 months of treatment. The goal is to see if this common treatment might raise or lower…