Could a simple estrogen cream restore sexual health for breastfeeding moms?
NCT ID NCT05457972
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a vaginal estrogen cream (Imvexxy) can improve sexual function in breastfeeding women who are 6 weeks to 6 months postpartum. About 100 participants will either use the estrogen cream or a placebo-like vitamin E suppository for 12 weeks. The goal is to see if the cream helps with desire, arousal, and overall sexual satisfaction without interfering with breastfeeding.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Estradiol (vaginal estrogen cream, brand name Imvexxy)
What this could lead to
If it works, this could offer a safe, effective option to improve sexual function and vaginal health for breastfeeding women without affecting milk supply.
What could go wrong
This is a small Phase 4 trial with only 100 participants, so results may not apply to all women. The estrogen cream may cause local irritation or spotting, and long-term effects during breastfeeding are not fully known.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University Hospitals Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••