Physiological sexual disorder

This study tests whether taking sildenafil (a drug for erectile dysfunction) daily for 10 months, starting 30 days after surgery, can prevent long-term erectile problems in men treated for rectal cancer with radiation and surgery. The trial includes 188 men aged 18 to 70 who had …

This study tests whether injecting stem cells or their exosomes into the penis can improve erectile function in men with diabetes who haven't been helped by standard treatments. Ninety men will receive either a placebo, stem cells, or exosomes in a single injection. Researchers w…

This study is testing a new implantable device that delivers electrical pulses to nerves to help men get erections after prostate removal for cancer. Twenty men aged 30-70 who are already scheduled for nerve-sparing prostatectomy will either get the device or not. Researchers wil…

This study looks at whether two common statins (pitavastatin and rosuvastatin) affect male sex hormones and erectile function in men aged 40-65 with high heart risk. Researchers will monitor 150 men for 6 months, checking hormone levels, erectile function, and blood vessel health…

This study tests a surgical technique that grafts nerves to help men who have had lasting erectile dysfunction (ED) for over 18 months after prostate cancer surgery. About 100 men will receive the procedure and be followed for one year to see if their erections improve and if the…

This study tests a precise type of radiation therapy (MRgRT) that aims to protect the nerves and blood vessels needed for erections in 70 men with low- or intermediate-risk prostate cancer. Participants receive 5 high-dose radiation sessions guided by MRI. The goal is to see if t…

This study tests whether a noninvasive spinal cord stimulation device can safely improve bladder, bowel, and sexual function in people with spinal cord injury. About 60 veterans and adults in Canada and Ukraine will receive either real or sham stimulation alongside standard rehab…

This study is testing a new inflatable penile implant called Rigicon Infla10 for men with erectile dysfunction. About 182 men will receive the implant and be followed for up to 3 years to see if it is safe and works well. The main goal is to check for serious side effects and whe…

This study is a safety follow-up for 32 men who previously received an experimental stem cell treatment (Cellgram-ED) for erectile dysfunction after prostate removal due to cancer. Researchers are monitoring tumor markers, serious side effects, and any cancer recurrence over time…

This study looks at whether adding regular exercise (treadmill walking) to vitamin D supplements can improve erectile function in men with type 2 diabetes who also have low vitamin D. Forty men will take vitamin D every two weeks for 12 weeks; half will also walk three times a we…

This study tests whether adding low-intensity shockwave therapy to standard Xiaflex injections can better reduce penile curvature in men with Peyronie's disease. Sixty participants will receive both treatments or Xiaflex alone. The goal is to improve sexual function and reduce bo…

This study is testing a new inflatable penile implant called the Rigicon Infla10 for men with erectile dysfunction. Researchers will implant the device in 182 men and follow them for up to 3 years to see if it is safe and works well. The main goal is to check if the implant helps…

This study tests whether a pelvic floor muscle training program, delivered through a mobile app, can reduce urinary incontinence and other pelvic floor disorders after childbirth. About 734 first-time pregnant women will either follow the app-based training or receive standard ca…

This early study tests a new implantable device that stimulates nerves to help men recover natural erections after prostate cancer surgery. Twenty men aged 30-75 will receive the device during their prostate removal and be followed for 6 months. The main goals are to check if the…

This study compares two approaches to pelvic floor rehabilitation after childbirth: one group works with a specialist using physiotherapy, biofeedback, and electrical stimulation, while the other group trains at home using a mobile app. Researchers want to see if these programs c…

This study tests whether a natural supplement called L-citrulline can improve mild to moderate erectile dysfunction as well as the standard drug tadalafil (Cialis), and whether taking both together works even better. About 133 men aged 30-70 will take one of three treatments dail…

This study tests a web-based program called OMGYES.com to see if it helps young adult female cancer survivors who have sexual problems. About 30 people will take part, using online modules at home and visiting the clinic every 5 weeks for questionnaires. The goal is to see if the…

This study tests three pelvic floor treatments in 150 men with lifelong premature ejaculation: electromagnetic stimulation, biofeedback training, and standard exercises. The goal is to see which best increases ejaculation time and improves control. Participants will be treated fo…

This study tests whether applying a powder called ARISTA AH during robotic prostate removal can reduce blood loss and help preserve erectile function. About 362 men with prostate cancer will be randomly assigned to receive the powder or standard care. The goal is to see if the po…

This study tests a new gel called ST-04 that is placed inside the urethra (the tube in the penis) to help men with erectile dysfunction (ED) who haven't had success with standard pills. The gel contains a medicine that widens blood vessels to produce an erection. About 83 men wil…

This study looks at whether saving a small extra artery to the penis during robotic prostate cancer surgery can help men recover erections. About 1 in 3 men have this artery, and the study will use MRI scans to find it before surgery. Researchers will follow 20-40 men for a year …

This study tests whether special pelvic floor exercises, guided by a biofeedback device, can improve sexual function in women who had radiation for cervical cancer. Sixty survivors with sexual problems will be randomly assigned to either biofeedback-assisted training or standard …

This study tests whether low-intensity shockwave therapy or pulsed electromagnetic field therapy, each combined with pelvic floor muscle training, can improve sexual function in women with sexual dysfunction. 90 premenopausal women aged 20-50 will be randomly assigned to one of t…

This study tests a device that delivers gentle shockwaves to the penis to help men with erectile dysfunction (ED). Researchers want to find out which patients see real improvement after treatment. About 157 men with ED will receive the therapy and be followed for 3 months. The go…

This study compares two methods to help men regain erectile function after prostate cancer surgery. About 224 men who had surgery within the past 9 months will take part. The goal is to see which approach works better for sexual rehabilitation.

This study tests whether a mobile app with educational videos, pelvic floor exercises, and reminders can improve recovery of bladder control and erectile function in men after prostate cancer surgery. About 78 men scheduled for prostate removal will be randomly assigned to either…

This study tests whether a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. The program includes educational sessions, brain games, and tips on physical activity and nutrition. Researchers will enroll 106 survivors and m…

This study is testing a new digital application called SHIFT to see if it can improve sexual health, quality of life, and reduce distress in people who have had a stem cell or bone marrow transplant. The trial will enroll 300 adult survivors who are at least three months post-tra…

This study tests whether a vaginal estrogen cream (Imvexxy) can improve sexual function in breastfeeding women who are 6 weeks to 6 months postpartum. About 100 participants will either use the estrogen cream or a placebo-like vitamin E suppository for 12 weeks. The goal is to se…

This study tests whether an 8-week pelvic floor exercise program can improve erectile dysfunction and premature ejaculation in men aged 25-45. Half of the 50 participants will do the exercises three times a week, while the other half receives standard medical care. The goal is to…

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

This study is testing whether two devices used together can help perimenopausal and postmenopausal women with depression and sexual issues. One device delivers magnetic pulses to the brain (EXOMIND), and the other stimulates the pelvic floor muscles (EMSELLA). Sixty women aged 40…

This study tests a device called VERTICA® that uses radio frequency energy to treat erectile dysfunction (ED). About 98 men with mild to moderate ED will use the device at home for 6 months, either the real device or a sham version. The goal is to see if the device improves erect…

This study tests whether taking a daily low-dose tadalafil plus an on-demand higher-dose sildenafil works better than on-demand sildenafil alone for men with erectile dysfunction who haven't responded to standard treatments. About 500 men will take the combo or a placebo for 12 w…

This study compares how a single plant-based meat meal (a Beyond Meat product) versus an animal meat meal affects erectile function in 30 healthy men with normal erections. Participants eat one meal and then wear a Rigiscan device overnight to measure erection hardness and freque…

This study is testing whether pelvic floor therapy—a mix of exercises, biofeedback, and mild electrical stimulation—can help men with erectile dysfunction and/or premature ejaculation. Sixty-six men will be split into three groups based on their condition and will receive the the…

This study tests if focused or radial shockwave therapy can improve erectile dysfunction and chronic pelvic pain better than a fake (sham) treatment. It includes 186 men, some with a history of prostate cancer. Participants will receive several sessions of shockwave or sham thera…

This pilot study tests a non-invasive 3D-printed external device to help men with erectile dysfunction achieve satisfactory sexual intercourse. Nine men with moderate to severe ED from any cause, along with their female partners, will try the device. The goal is to see if it is s…

This pilot study from the University of Michigan is testing whether a non-invasive nerve stimulation device, used at home, can improve sexual arousal in women with female sexual dysfunction. Twenty-four participants will use the UCon patch system to stimulate the dorsal genital n…

This study tests whether 4-aminopyridine (4-AP) can help men recover faster from nerve damage caused during prostate cancer surgery. About 70 men aged 45-75 with early-stage prostate cancer will take the drug or a placebo after their operation. The goal is to see if it improves b…

This study tests whether adding aerobic exercise (like walking on a treadmill) to cognitive behavioral therapy can improve erectile function in heavy drinking men who also have metabolic syndrome and impotence. Forty men will be split into two groups: one gets only talk therapy, …

This study is testing SHAReClinic, a national virtual clinic that provides sexual health education and counselling to prostate cancer patients and their partners. Researchers will enroll 575 people across Canada to see if the program improves sexual function, reduces distress, an…

This study tests whether the BTL Emsella Chair, a device that uses electromagnetic energy, can help men with sexual dysfunction, including erectile and ejaculatory problems. The trial has two phases: first, a small pilot study where all 10 men get active treatment, followed by a …

This study tests whether a non-invasive spinal cord stimulation device can improve autonomic functions like blood pressure, bladder, bowel, and sexual control in people with chronic spinal cord injury. Thirty participants will receive targeted stimulation over several weeks. The …

This early-stage study tests whether taking a new liquid form of sildenafil (Hezkue Turbo®) with food changes how the body absorbs it compared to taking it on an empty stomach. Twelve healthy men aged 20 to 70 will each receive a 100 mg dose under both conditions. The goal is to …

This study tests whether using a penile traction device (RestoreX) for 3 months before getting a penile implant can increase the length of the implant and improve patient satisfaction. About 48 men with erectile dysfunction will be randomly assigned to use the device or not. The …

This study investigates why some men have difficulty using the pump of their inflatable penile prosthesis after surgery, leading to dissatisfaction. Researchers will look at factors like age, weight, pump type, and whether patients saw a demonstration before surgery. The goal is …

This study aims to find out if chronic pelvic pain conditions like prostatitis and interstitial cystitis can be inherited. Researchers will collect DNA and urine from 500 participants, including family members, to look for genetic links. The goal is to better understand the cause…

This study is looking at 210 women who are having a routine procedure called endometrial sampling, which helps diagnose abnormal uterine bleeding. The goal is to see if the type of anesthesia used—either sedation or local numbing—affects their sexual function one month later. Par…

This study asks 100 adult men to stop watching pornography for 30 days and tracks changes in nighttime erections, sexual function, and mood using a wearable device and surveys. Participants first observe their normal habits for a short period, then compare results during abstinen…

This study looks at whether women with high blood pressure who skip their medication have more sexual problems than those who take it regularly. Researchers will compare sexual function in 348 women using questionnaires and blood tests. The goal is to understand if not taking med…

This study looks at how Traditional Medicine classifies erectile dysfunction (ED) into different patterns and how those patterns relate to a man's age, lifestyle, and mental health. Researchers will study 375 men with ED in Vietnam to better understand these connections. The goal…

This study follows 100 men aged 30-75 who had a heart procedure called PCI (stent placement) to open blocked arteries. Researchers want to see how erectile function changes over 6 months, comparing those who had a heart attack to those with stable chest pain. Participants fill ou…

This study looks at how infertility and fertility treatments like IVF affect women's sexual function and behavior. About 500 women under 45 with infertility will fill out an anonymous questionnaire about their sexual desire, satisfaction, and activities. The goal is to help docto…

This study is testing whether a simple finger device called EndoPAT can measure blood vessel function in men aged 30–50 with erectile dysfunction or low testosterone. About 120 men will use the device before and after taking daily low-dose ED medication or testosterone therapy. T…

This study follows 150 adults with cirrhosis who are waiting for a liver transplant. Researchers will use questionnaires and blood tests to measure sexual function before and one year after the transplant. The goal is to understand how transplantation changes sexual health and wh…

This study is for men who have had a penile prosthesis implanted for erectile dysfunction. It aims to understand how well they can manipulate the pump, including hand strength and sensation. Researchers will also look at how these abilities relate to erection rigidity and sexual …

This observational study follows 80 women treated with chemoradiotherapy for anal cancer to understand how radiation affects their vaginal and sexual health. Participants will have a gynecological exam, complete questionnaires about quality of life and sexual health, and allow re…

This study looks at whether thyroid-stimulating hormone (TSH) levels in pregnant women are linked to depression, anxiety, sexual function, and quality of life. Researchers will measure TSH and use questionnaires to assess mood and sexual health in 180 pregnant women. The goal is …

This study looks at how plant-based meals compare to animal-based meals on erectile function in 46 healthy men with normal erections. Participants eat specially prepared meals and wear a device to measure nighttime erections. The goal is to see if diet alone can make a difference…

This study aims to find out how often sexual dysfunction occurs in women with relapsing-remitting multiple sclerosis and how it connects to fatigue, depression, anxiety, overactive bladder, and thinking problems. Researchers will use questionnaires and tests to measure these fact…