New combo pill approach aims to help men with Hard-to-Treat erectile dysfunction
NCT ID NCT07391579
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether taking a daily low-dose tadalafil plus an on-demand higher-dose sildenafil works better than on-demand sildenafil alone for men with erectile dysfunction who haven't responded to standard treatments. About 500 men will take the combo or a placebo for 12 weeks, and researchers will measure changes in erectile function and hardness scores. The goal is to find a safe, effective option for those who currently have few alternatives.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tadalafil and sildenafil
What this could lead to
If it works, this could offer a new treatment option for men with erectile dysfunction who do not respond to standard pills alone.
What could go wrong
This is a Phase 4 trial, but it only lasts 12 weeks and focuses on a specific group of non-responders. The combination may not work for everyone and could cause side effects like headache or flushing.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cairo University, faculty of medicine
RECRUITINGCairo, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Faculty of Medicine - Assiut University
RECRUITINGAsyut, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Faculty of medicine, Ain Shams University
RECRUITINGCairo, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Faculty of medicine, Alexandria University
RECRUITINGAlexandria, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Faculty of medicine, Aswan university
RECRUITINGAswān, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Faculty of medicine, Azhar University
RECRUITINGCairo, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Faculty of medicine, Luxor university
RECRUITINGLuxor, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Faculty of medicine, Tanta University
RECRUITINGTanta, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Faculty of medicine, october 6 Univeristy
RECRUITINGCairo, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Urology and Nephrology Center, Mansoura University
RECRUITINGAl Mansurah, Dakahlia Governorate, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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faculty of medicine, Minya University
RECRUITINGMinya, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••