New combo pill approach aims to help men with Hard-to-Treat erectile dysfunction

NCT ID NCT07391579

Recruiting now Symptom relief Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking a daily low-dose tadalafil plus an on-demand higher-dose sildenafil works better than on-demand sildenafil alone for men with erectile dysfunction who haven't responded to standard treatments. About 500 men will take the combo or a placebo for 12 weeks, and researchers will measure changes in erectile function and hardness scores. The goal is to find a safe, effective option for those who currently have few alternatives.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tadalafil and sildenafil
What this could lead to: If it works, this could offer a new treatment option for men with erectile dysfunction who do not respond to standard pills alone.
What could go wrong: This is a Phase 4 trial, but it only lasts 12 weeks and focuses on a specific group of non-responders. The combination may not work for everyone and could cause side effects like headache or flushing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

erectile dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ERECTILE DYSFUNCTIONS

Contacts and locations

Locations

Cairo University, faculty of medicine
RECRUITING

Cairo, Egypt
Faculty of Medicine - Assiut University
RECRUITING

Asyut, Egypt
Faculty of medicine, Ain Shams University
RECRUITING

Cairo, Egypt
Faculty of medicine, Alexandria University
RECRUITING

Alexandria, Egypt
Faculty of medicine, Aswan university
RECRUITING

Aswān, Egypt
Faculty of medicine, Azhar University
RECRUITING

Cairo, Egypt
Faculty of medicine, Luxor university
RECRUITING

Luxor, Egypt
Faculty of medicine, Tanta University
RECRUITING

Tanta, Egypt
Faculty of medicine, october 6 Univeristy
RECRUITING

Cairo, Egypt
Urology and Nephrology Center, Mansoura University
RECRUITING

Al Mansurah, Dakahlia Governorate, Egypt
faculty of medicine, Minya University
RECRUITING

Minya, Egypt

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