Physiological sexual disorder

This study looked at 156 men with mild to mild-moderate erectile dysfunction who had not responded well to previous treatments. Half received platelet-rich plasma (PRP) injections into the penis plus a daily 5 mg tadalafil pill, while the other half got PRP injections alone. The …

This early-phase trial tested whether combining shockwave therapy with platelet-rich plasma (PRP) injections can improve erectile function in men with microvascular erectile dysfunction. Fifty-nine men received either the combination treatment or a sham procedure. The main goal w…

This study looked at 60 men with metabolic syndrome who also had erectile dysfunction and early signs of heart stiffness. Researchers compared three treatments: tadalafil (a common ED drug), an SGLT2 inhibitor (a diabetes drug), and a combination of both, given for three months. …

This phase 2 trial tested a single injection of stem cells (from the patient's own bone marrow) into the penis to treat erectile dysfunction in men who had their prostate removed due to cancer. Fifty-four men participated. The study measured changes in erectile function scores us…

This study tested whether a single injection of a patient's own fat-derived stem cells into the penis could improve erectile dysfunction after prostate removal. 70 men who had poor erections for over a year after surgery were enrolled. Half received the stem cell injection, half …

This study tested a drug called crizanlizumab in 36 men with sickle cell disease who suffer from priapism—painful erections lasting an hour or more. The goal was to see if the drug could reduce how often these events happen. Participants received the drug by IV and reported their…

This early-phase trial tested whether injecting a man's own bone marrow stem cells into the penis could help restore erections after prostate cancer surgery. The study included 18 men who had normal erections before surgery but developed erectile dysfunction due to blood vessel d…

This study tested whether a 12-week Pilates program could improve erectile function in 60 men aged 40-60 with type 2 diabetes and erectile dysfunction. Participants did Pilates three times a week for 60 minutes each session. The study measured blood flow in the penis and used a q…

This pilot study tested low-intensity shock wave therapy (LiSWT) in 25 men with erectile dysfunction after a pelvic fracture and urethral injury. The treatment uses a device that delivers gentle shock waves to the penis to improve blood flow. Researchers measured changes in penil…

This study tested a treatment called percutaneous tibial nerve stimulation (PTNS) for women with sexual dysfunction. 79 women received either real PTNS or a fake version to see if it improved their sexual function. The goal was to find a non-drug option for this common problem.

This study tested whether one-on-one sessions with a trained nurse could help people with resistant hypertension better handle side effects like sexual problems and bladder control issues caused by their blood pressure medications. The goal was to see if this education helps pati…

This study tested two treatments for erectile dysfunction (ED) in 185 men: a daily tadalafil pill (5 mg) and a nerve stimulation device (TENS) that sends mild electrical pulses to the penis. The goal was to see if these treatments improve blood flow and erection hardness. The tri…

This study tested a behavioral program called AWARE for college women aged 18-24 who have experienced sexual trauma and drink heavily. The program includes individual and group sessions to reduce alcohol use, sexual distress, and risk of future assault. Researchers followed 86 pa…

This study looked at whether using a vaginal dilator for 12 weeks helps women who had brachytherapy for cervical cancer. Researchers measured sexual function, self-compassion, and quality of life in 80 participants at three time points. The goal was to see if this simple tool can…

This study tested a program to help stem cell transplant survivors who have sexual problems. Participants met with a nurse for three months and got educational materials. The goal was to see if this improved their sexual satisfaction, quality of life, and mood. The study involved…

This study tested whether specialized sexual nursing care could help stroke patients and their partners manage sexual difficulties. Thirty stroke survivors and their partners were split into two groups: one received personalized counseling and education from trained nurses, while…

This study looked at whether a 10-week pelvic physical therapy program is practical for gynecologic cancer survivors who have sexual problems. Twenty survivors were enrolled to see if they could stick with the program and if it improved their sexual function and quality of life. …

This study tested whether injecting Botox into the penis and a nearby pelvic muscle can help men with lifelong premature ejaculation last longer during sex. 150 men were randomly assigned to receive either Botox or a placebo injection. The researchers measured ejaculation time an…

This study tested whether adding radial shock wave therapy to standard sildenafil (Viagra) helps men with erectile dysfunction more than sildenafil alone. Eighty men with moderate ED were randomly assigned to receive either real shock waves or a fake treatment, plus sildenafil. T…

This study tested a topical gel called MED3000 for men with erectile dysfunction that persisted 1.5 to 4 years after prostate cancer surgery. Twenty men who had nerve-sparing prostatectomy used the gel on demand. The goal was to see if it improved erectile function enough to make…

This study followed 317 men who used a digital health app (Kranus EDERA) for erectile dysfunction to see if their improvements lasted. Participants completed questionnaires about erectile function, overall health, and quality of life up to 3 months after finishing the 12-week app…

This study tested whether adding a magnetic chair (extracorporeal magnetic innervation) to standard pelvic floor exercises helps men with premature ejaculation more than exercises alone. Forty-one men aged 25-45 took part over 8 weeks. Researchers measured pelvic floor muscle mov…

This study tested a new treatment for female sexual dysfunction using the women's own stem cells. Fifty women aged 40-50 received stem cell infusions or served as a control group. The goal was to see if the therapy safely improves sexual function and quality of life. Results are …

This study tested an online nurse-led program to help young women who had breast cancer improve their sexual health, body image, and menopausal symptoms. 43 women who finished treatment within the last five years took part in eight weekly sessions. The program aimed to see if it …

This study tested a 4-week online mindful compassion program for women who had finished cancer treatment and were in hospice care at home. The goal was to see if it could improve sexual function, well-being, and quality of life. Twenty-two women took part, and the program include…

This study tested a drug called Tanzânia in 295 men who have both erectile dysfunction and an enlarged prostate (benign prostatic hyperplasia). The goal was to see if the drug improves erectile function better than a placebo. Participants took the drug or a dummy pill for a perio…

This early-stage study tested a new mind-body program designed to help female survivors of colorectal and anal cancer improve their sexual well-being. Six women who had finished initial cancer treatment took part in group sessions. The main goal was to see if the program was acce…

This study tested whether an injection of umbilical cord stem cell secretome is safe and can improve erections in 12 men with severe erectile dysfunction that did not respond to sildenafil (Viagra). All participants had type 2 diabetes. The treatment was given as a single injecti…

This study tested a new oral film form of sildenafil (the active ingredient in Viagra) at doses from 25 mg to 100 mg in 488 men with erectile dysfunction (ED). The goal was to see if the film is safe and effective compared to a placebo. Participants took the film as needed before…

This phase 2 trial tested whether estetrol (E4), a hormone pill, can help postmenopausal women with female sexual arousal disorder. 82 women took either estetrol or a placebo for 12 weeks. Researchers measured changes in sexual arousal and distress to see if the drug works better…

This study aimed to develop and test two new questionnaires for people with recurrent urinary tract infections (UTIs). The Recurrent UTI Symptom Scale measures symptom severity, while the Recurrent UTI Impact Questionnaire looks at how the condition affects daily life, work, and …

This study followed up with 69 women who had pelvic pain for over 6 months to see if a special pain education class still helped them 5 years later. The women filled out questionnaires about their pain, daily life, and sexual function. The goal was to find out if the benefits of …

This study surveyed 385 women aged 35 or younger with early-stage breast cancer to learn their attitudes about the risk of infertility from adjuvant therapy. The goal was to understand how concerns about having children might influence their treatment choices. The results could h…

This study looks at why some men feel anxious about giving themselves penile injections for erectile dysfunction after pelvic surgery. Researchers will ask 126 men to fill out questionnaires before, during, and after injection training. The goal is to better understand and measur…

This completed observational study investigated sexual dysfunction in women with anorexia nervosa, comparing them to healthy women. Researchers used questionnaires to measure sexual function and eating disorder symptoms. The goal was to understand how anorexia may affect sexual h…

This completed study examined the link between erectile dysfunction, nerve pain, disease activity, and daily function in 90 men with axial spondyloarthritis (a type of arthritis affecting the spine). Participants were either on anti-TNF drugs, NSAIDs, or were healthy volunteers. …

This study tested whether an educational video series about sexual health is acceptable and useful for women undergoing breast cancer treatment. 32 women with early-stage breast cancer watched the videos over six months. Researchers measured how well the videos were received and …

This study looked at sexual problems in 553 adults with lung cancer. Researchers wanted to find out how common these issues are and how severe they can be. The goal is to help doctors better support patients during and after cancer treatment.

This study in 18 rats investigates whether alpha lipoic acid, a natural antioxidant, can protect penile tissue from damage caused by restoring blood flow after a prolonged painful erection (priapism). Researchers will measure various markers of oxidative stress and inflammation i…

This study translated a detailed questionnaire about male sexual function into French and tested it with 14 men who have sexual dysfunction. The goal was to see if the questions were clear and easy to understand. This is a first step toward having a reliable tool for French-speak…

This study tested 14 elite male road cyclists to see how different bike saddle designs affect oxygen and carbon dioxide levels in the penis. Riders used a stationary trainer while researchers measured blood gas changes over time. The goal was to compare a new 3D-printed saddle wi…

This study looked at how bladder cancer surgery (cystectomy) affects patients' sexual quality of life over time. Researchers gave 50 participants questionnaires before and 8 months after surgery to track changes. The goal is to better understand long-term effects that are often o…

This study looked at whether a score called Modified EASIX, calculated from routine blood tests, can help predict how severe erectile dysfunction (ED) is. Researchers reviewed medical records of 380 men aged 18-65 and compared the score between those with and without ED. No treat…

This study looked at how much women in Turkey know about their pelvic floor muscles and Kegel exercises. Researchers surveyed 182 women who were sexually active and over 18. They measured knowledge, sexual function, and quality of life to understand awareness levels and identify …

This small study tested whether mild nerve stimulation could increase vaginal blood flow in women with sexual problems, spinal cord injury, or no issues at all. Nine women had a small sensor placed in the vagina to measure blood flow changes during stimulation. The goal was to un…

This completed study looked at 97 men with type 2 diabetes to see if a non-invasive skin test for advanced glycation end-products (AGEs) could be linked to erectile dysfunction. AGEs build up due to high blood sugar and may damage blood vessels. Researchers used a device called A…

This study looked at whether ospemifene, a non-hormonal drug for vaginal dryness, also affects brain activity in postmenopausal women with sexual interest-arousal disorder. Twenty-five women took the drug or a placebo and underwent brain scans while watching sexual videos or smel…