Could a hormone pill reignite desire? new trial tests estetrol for postmenopausal sexual arousal

NCT ID NCT06308614

Completed Symptom relief Sponsor: Estetra Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This phase 2 trial tested whether estetrol (E4), a hormone pill, can help postmenopausal women with female sexual arousal disorder. 82 women took either estetrol or a placebo for 12 weeks. Researchers measured changes in sexual arousal and distress to see if the drug works better than a dummy pill.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: estetrol (E4)
What this could lead to: If it works, this could point toward a hormone-based treatment for sexual arousal difficulties in postmenopausal women.
What could go wrong: This is a small, early-phase proof-of-concept study with only 82 participants. The results may not show a clear benefit over placebo, and more research would be needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

physiological sexual disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEXUAL DYSFUNCTION, PHYSIOLOGICAL

Contacts and locations

Locations

Estetra Study Site

Mesa, Arizona, 85209, United States
Estetra Study Site

Phoenix, Arizona, 85032, United States
Estetra Study Site

Tucson, Arizona, 85715, United States
Estetra Study Site

Pomona, California, 91767, United States
Estetra Study Site

San Diego, California, 92111, United States
Estetra Study Site

Jacksonville, Florida, 32256, United States
Estetra Study Site

Miami, Florida, 33173, United States
Estetra Study Site

New Port Richey, Florida, 34562, United States
Estetra Study Site

Ocoee, Florida, 34761, United States
Estetra Study Site

Orlando, Florida, 32801, United States
Estetra Study Site

West Palm Beach, Florida, 33409, United States
Estetra Study Site

Atlanta, Georgia, 30328, United States
Estetra Study Site

Chicago, Illinois, 60643, United States
Estetra Study Site

Omaha, Nebraska, 68114, United States
Estetra Study Site

Las Vegas, Nevada, 89109, United States
Estetra Study Site

Albuquerque, New Mexico, 87102, United States
Estetra Study Site

Cleveland, Ohio, 44106, United States
Estetra Study Site

Englewood, Ohio, 45322, United States
Estetra Study Site

Memphis, Tennessee, 38119, United States
Estetra Study Site

Houston, Texas, 77061, United States
Estetra Study Site

Houston, Texas, 77074, United States
Estetra Study Site

Salt Lake City, Utah, 84107, United States
Estetra Study Site

Virginia Beach, Virginia, 23456, United States
Estetra Study Site

Seattle, Washington, 98104, United States

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