Can adjusting drug schedules improve both urinary and sexual outcomes in men with enlarged prostate?
NCT ID NCT07715448
First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time
Summary
This clinical trial investigates whether different dosing schedules of tadalafil or tamsulosin, when combined with a 5-alpha reductase inhibitor, can better manage urinary symptoms and preserve sexual function in men with benign prostatic hyperplasia (BPH). The study includes 240 men aged 50 and older with moderate to severe symptoms and an enlarged prostate. Over 12 weeks, researchers will measure changes in urinary symptoms, erectile function, and ejaculatory function to find the optimal combination regimen.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tadalafil or tamsulosin combined with a 5-alpha reductase inhibitor (finasteride or dutasteride)
- What this could lead to
- If successful, this could identify the most effective dosing regimen to improve both urinary symptoms and sexual function in men with an enlarged prostate.
- What could go wrong
- This is a single-blind, 12-week study with 240 participants, so results may not apply to all men or longer-term use. Side effects from these drugs can include dizziness, low blood pressure, and sexual side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beni-Suef University Hospital
Banī Suwayf, Beni Suef Governorate, Egypt
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