BENIGN PROSTATIC HYPERPLASIA

This study looks at whether men with an enlarged prostate who take blood thinners can safely stay on them during laser surgery. About 389 men will be randomly assigned to either continue their blood thinners or stop them temporarily. The goal is to see if continuing blood thinner…

This early-stage study tests two versions of an experimental drug for benign prostatic hyperplasia (enlarged prostate) in 44 healthy adult men. Each participant receives both drugs at different times to compare safety and how the body processes them. The goal is to see which vers…

This study tests a new device called the Glean Urodynamics System, which uses sensors and an app to monitor bladder function both in the clinic and at home. It includes 101 adults with bladder issues like overactive bladder or incontinence. The goal is to see if the device is saf…

This study tests whether adding tadalafil (a daily pill for erection problems and enlarged prostate) to standard tamsulosin helps men aged 50+ who suddenly can't urinate due to an enlarged prostate. After a catheter is placed, participants take either tamsulosin plus tadalafil or…

This study compares two procedures for enlarged prostate: water vapor therapy (Rezum) and a special laser technique that aims to preserve ejaculation. 120 sexually active men aged 50+ with moderate-to-severe symptoms will choose their treatment after counseling. The main goal is …

This study compares two minimally invasive procedures for men with an enlarged prostate: water vapor thermal therapy (Rezum) and ejaculation-sparing surgery. It includes 120 sexually active men aged 50 or older who have moderate-to-severe urinary symptoms. The goal is to see whic…

This study tests a device called the Axonics SNM System, which uses mild electrical pulses to calm the nerves that control the bladder. It is for men with overactive bladder, including those with urgency incontinence or frequent urination. The trial will enroll 150 men and track …

This study looks at men over 50 with an enlarged prostate who had a sudden inability to urinate and needed a catheter. All were already taking tamsulosin 0.4 mg daily. The trial compares three options over 7 days: staying on the same dose, doubling it, or switching to silodosin. …

This study tests a device called FloStent, a small tube placed in the prostate to help urine flow more easily in men with an enlarged prostate (benign prostatic hyperplasia). About 215 men with moderate to severe symptoms will either get the FloStent or a sham procedure where not…

This study compares two different lasers used during surgery for an enlarged prostate (BPH). The goal is to see which laser reduces bleeding time during the operation. About 180 men will take part, and the results will help surgeons choose the best tool for this common procedure.

This study compares a new, ejaculation-sparing version of standard prostate surgery (HoLEP) for men with enlarged prostates. The goal is to relieve urinary symptoms while preserving the ability to ejaculate normally. Researchers will enroll 48 sexually active men and track ejacul…

This study tests a new surgical technique for men with an enlarged prostate who have not gotten relief from medication. The goal is to improve urination while preserving the ability to ejaculate. Sixty sexually active men will be randomly assigned to either the new ejaculation-pr…

This study tests a new device that uses focused sound waves to break down extra prostate tissue without cuts or needles. It includes 80 men aged 50 and older with an enlarged prostate causing bothersome symptoms. The main goal is to check if the procedure is safe.

This study tests a modified surgery that aims to preserve ejaculation in men over 40 with an enlarged prostate, compared to the standard complete removal of prostate tissue. The goal is to see if the new method can relieve urinary symptoms just as well while avoiding the common s…

This study tracks 500 men with symptomatic benign prostatic hyperplasia (BPH) who receive the Optilume BPH Catheter System in real-world clinics. The goal is to see how well the device eases urinary symptoms and how safe it is over 12 months. Participants must follow contraceptio…

This study is testing a new robotic system to help surgeons remove extra prostate tissue in men with an enlarged prostate (BPH). The goal is to see if the robot can safely and effectively ease urinary symptoms. About 54 men will take part, and the main focus is on how many surger…

This study compares two methods of pain control during a water vapor therapy (Rezum) for enlarged prostate. One group gets general anesthesia, the other gets local anesthesia injected directly into the prostate using a special catheter. The goal is to see if local anesthesia can …

This study tests whether adding Lingze tablets, a traditional Chinese medicine, to the standard drug tamsulosin can help men who still wake up often at night to urinate after prostate surgery. About 136 men aged 50 and older will be randomly assigned to take either tamsulosin alo…

This study tests the Optilume BPH Catheter System, a device with a drug-coated balloon that opens the prostate to improve urine flow. About 92 men aged 50 and older with moderate to severe symptoms will be treated. Researchers will check if symptoms improve and track any serious …

This study tests whether doing pelvic floor muscle exercises before and after prostate surgery can improve urinary symptoms like urgency, dribbling, and frequent urination in men with an enlarged prostate. About 46 participants will either do the exercises or receive standard car…

This study tests a new care plan that lets patients go home just 24 hours after laser surgery for an enlarged prostate, instead of the usual 48 hours. Nurses will supervise recovery at home. The goal is to see if this shorter stay is safe and does not lead to more complications o…

This study compares spinal anesthesia to general anesthesia in men undergoing open simple prostatectomy for an enlarged prostate. The goal is to see if spinal anesthesia leads to less postoperative bleeding, such as fewer blood transfusions or less need for bladder irrigation. Ei…

This study is creating a worldwide registry to track how well different surgical treatments work for benign prostatic hyperplasia (BPH), a condition where the prostate gland enlarges and causes urinary problems. Researchers will collect data from 7,500 participants to compare sym…

This study looks at whether watching a short educational video after HoLEP prostate surgery helps patients manage their recovery at home and reduces the need to call or visit the doctor. About 114 adults having the procedure will be randomly assigned to either watch the video or …

This study tests a new device designed to control bleeding after prostate surgery (TURP). The device applies steady pressure to the urethra using a catheter. Researchers will compare it to standard methods on mannequins. Sixty healthcare workers will evaluate how easy, safe, and …

This study aims to understand why some men with an enlarged prostate (BPH) do not respond to the common drug finasteride. Researchers will follow 120 men starting finasteride, tracking their symptoms and using MRI scans and genetic tests over three years. The goal is to find ways…