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Can a two-drug combo better tame prostate trouble?

NCT ID NCT07722884

Recruiting now Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether adding tadalafil to the standard drug tamsulosin improves urinary symptoms in men with an enlarged prostate (BPH). Ninety men over 45 with moderate-to-severe symptoms will receive either tamsulosin alone or tamsulosin plus a low (2.5 mg) or standard (5 mg) dose of tadalafil daily for 12 weeks. The goal is to see if the combination offers better symptom relief and quality of life, and whether the lower dose can match the higher one with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tamsulosin and tadalafil
What this could lead to
If the lower-dose combination works as well as the higher one with fewer side effects, it could offer a gentler option for managing BPH symptoms.
What could go wrong
This is a small, short-term trial (90 men, 12 weeks). Results may not apply to all men, and side effects like dizziness or headache are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

benign prostatic hyperplasia Lower Urinary Tract Symptoms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BENIGN PROSTATIC HYPERPLASIA EFFICACY LOWER URINARY TRACT SYMPTOMS MONOTHERAPY SAFETY TADALAFIL TAMSULOSIN

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Ain Shams University

    RECRUITING

    Cairo, Cairo Governorate, 11591, Egypt

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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