Benign prostatic hyperplasia

This study is tracking 238 adults who are already scheduled to have a procedure for kidney stones or an enlarged prostate (BPH) using Boston Scientific devices. The main goal is to see how often serious side effects happen with these tools in real-world use. Researchers will also…

This trial compares two laser methods (MoLEP and ThuFLEP) for removing prostate tissue in men with enlarged prostates (over 80cc). 120 men aged 40-90 who need surgery will be randomly assigned to one of the two lasers. The main goal is to see which technique is faster, while also…

This study tests whether adding raloxifene to the standard drug finasteride works better than finasteride alone for men with an enlarged prostate (BPH). About 242 adults will take either the combo or finasteride plus a placebo for 12 months. The goal is to see if the combo improv…

This study looks at whether men with an enlarged prostate who take blood thinners can safely stay on them during laser surgery. About 389 men will be randomly assigned to either continue their blood thinners or stop them temporarily. The goal is to see if continuing blood thinner…

This early-stage study tests two versions of an experimental drug for benign prostatic hyperplasia (enlarged prostate) in 44 healthy adult men. Each participant receives both drugs at different times to compare safety and how the body processes them. The goal is to see which vers…

This study is testing a new type of radiation therapy that adapts to changes in the prostate and bladder during each treatment session. It is for men with localized prostate cancer who also have an enlarged prostate or urinary symptoms. The goal is to see if this approach can red…

This early-phase trial tests whether tranilast, a drug currently used for allergies, can help men with moderate to severe enlarged prostate (BPH). The study will include 30 men aged 55-75 with prostate volumes over 40mL and urinary symptoms. Participants will receive standard car…

This study tests a new device called the Glean Urodynamics System, which uses sensors and an app to monitor bladder function both in the clinic and at home. It includes 101 adults with bladder issues like overactive bladder or incontinence. The goal is to see if the device is saf…

This study tests a new ultrasound method to measure bladder function without invasive procedures. Researchers at Mayo Clinic will compare the new technique to standard tests in adults with bladder issues or enlarged prostate. The goal is to see if this painless approach can accur…

This study tests whether adding tadalafil (a daily pill for erection problems and enlarged prostate) to standard tamsulosin helps men aged 50+ who suddenly can't urinate due to an enlarged prostate. After a catheter is placed, participants take either tamsulosin plus tadalafil or…

This study compares two procedures for enlarged prostate: water vapor therapy (Rezum) and a special laser technique that aims to preserve ejaculation. 120 sexually active men aged 50+ with moderate-to-severe symptoms will choose their treatment after counseling. The main goal is …

This study compares two minimally invasive procedures for men with an enlarged prostate: water vapor thermal therapy (Rezum) and ejaculation-sparing surgery. It includes 120 sexually active men aged 50 or older who have moderate-to-severe urinary symptoms. The goal is to see whic…

This study tests a device called the Axonics SNM System, which uses mild electrical pulses to calm the nerves that control the bladder. It is for men with overactive bladder, including those with urgency incontinence or frequent urination. The trial will enroll 150 men and track …

This study looks at men over 50 with an enlarged prostate who had a sudden inability to urinate and needed a catheter. All were already taking tamsulosin 0.4 mg daily. The trial compares three options over 7 days: staying on the same dose, doubling it, or switching to silodosin. …

This study tests whether a daily CoQ10 supplement (Ralivia) can improve symptoms of benign prostatic hyperplasia (BPH), such as frequent or difficult urination. One hundred men aged 50–80 with moderate-to-severe BPH will receive either the supplement or a placebo for 3 months. Re…

This study tests a device called FloStent, a small tube placed in the prostate to help urine flow more easily in men with an enlarged prostate (benign prostatic hyperplasia). About 215 men with moderate to severe symptoms will either get the FloStent or a sham procedure where not…

This study compares two different lasers used during surgery for an enlarged prostate (BPH). The goal is to see which laser reduces bleeding time during the operation. About 180 men will take part, and the results will help surgeons choose the best tool for this common procedure.

This study compares a new, ejaculation-sparing version of standard prostate surgery (HoLEP) for men with enlarged prostates. The goal is to relieve urinary symptoms while preserving the ability to ejaculate normally. Researchers will enroll 48 sexually active men and track ejacul…

This study compares three different surgical techniques for men with very large prostates (over 100 mL) who have severe urinary symptoms. Ninety men will be randomly assigned to receive either thulium fiber laser, holmium laser, or bipolar electrosurgery. Researchers will measure…

This study tests a new surgical technique for men with an enlarged prostate who have not gotten relief from medication. The goal is to improve urination while preserving the ability to ejaculate. Sixty sexually active men will be randomly assigned to either the new ejaculation-pr…

This early study is testing a new, ultra-minimally invasive procedure for men with benign prostatic hyperplasia (BPH) who have significant urinary symptoms. The treatment uses a balloon catheter guided by ultrasound to gently widen the prostate passage. Only 5 men aged 40 to 80 w…

This study compares two laser surgeries—ThuLEP and HoLEP—for treating enlarged prostate symptoms in men. 150 men will be randomly assigned to one of the two procedures and followed for 12 months. The goal is to see which technique provides better symptom relief, faster recovery, …

This study follows 1000 men with an enlarged prostate who are receiving Rezum water vapor therapy, a minimally invasive steam treatment. The goal is to see how well it relieves urinary symptoms and improves quality of life over 5 years. Researchers will track symptom scores, urin…

This study tests the safety of a temporary implant called iTind, placed for 5-7 days, against the permanent UroLift system for men with enlarged prostate symptoms. About 206 men aged 50 and older will be randomly assigned to one treatment. The main goal is to see which causes few…

This study compares two common surgeries for men with an enlarged prostate causing urinary problems: standard TURP and a newer technique called bipolar enucleation (BEEP). About 120 men with moderate-sized prostates will be randomly assigned to one surgery. Researchers will measu…

This study compares two common surgeries for an enlarged prostate (BPH): a newer laser technique (MoLEP) and a standard electrical procedure (Bi-TURP). About 130 men with moderate to severe symptoms will be randomly assigned to one surgery. The main goal is to see which approach …

This study tests a device that sends mild electrical pulses to the pelvic floor muscles to help men who have bladder leakage after prostate cancer treatment. About 41 men with moderate leakage for at least 6 months will use the device at home for 20 minutes a day, 5 days a week, …

This study tests a new device that uses focused sound waves to break down extra prostate tissue without cuts or needles. It includes 80 men aged 50 and older with an enlarged prostate causing bothersome symptoms. The main goal is to check if the procedure is safe.

This study tests a modified surgery that aims to preserve ejaculation in men over 40 with an enlarged prostate, compared to the standard complete removal of prostate tissue. The goal is to see if the new method can relieve urinary symptoms just as well while avoiding the common s…

This study tracks 500 men with symptomatic benign prostatic hyperplasia (BPH) who receive the Optilume BPH Catheter System in real-world clinics. The goal is to see how well the device eases urinary symptoms and how safe it is over 12 months. Participants must follow contraceptio…

This study is testing a new robotic system to help surgeons remove extra prostate tissue in men with an enlarged prostate (BPH). The goal is to see if the robot can safely and effectively ease urinary symptoms. About 54 men will take part, and the main focus is on how many surger…

This study compares two procedures—water vapor therapy (Rezum) and prostatic artery embolization—for men with moderate-to-severe urinary symptoms from an enlarged prostate. Thirty men aged 50 and older who haven't responded to medication will be treated and followed for six month…

This study compares two methods of pain control during a water vapor therapy (Rezum) for enlarged prostate. One group gets general anesthesia, the other gets local anesthesia injected directly into the prostate using a special catheter. The goal is to see if local anesthesia can …

This study tests a laser treatment for men over 40 whose enlarged prostate symptoms returned after a prior minimally invasive procedure. The treatment is done in the doctor's office and aims to improve urination and sexual function, potentially avoiding more invasive surgery. Abo…

This study tests a liquid called INTUPRO that is injected into the prostate to shrink tissue and improve urine flow in men with enlarged prostate (BPH). 31 men aged 45+ with moderate to severe symptoms will receive the treatment and be followed for 3 months. The goal is to see if…

This study looks at whether injecting Botox into the bladder during standard prostate surgery (TURP or Aquablation) can reduce bothersome symptoms like frequent or urgent urination after the operation. Twenty men with an enlarged prostate and overactive bladder will be enrolled. …

This study tests whether adding Lingze tablets, a traditional Chinese medicine, to the standard drug tamsulosin can help men who still wake up often at night to urinate after prostate surgery. About 136 men aged 50 and older will be randomly assigned to take either tamsulosin alo…

This study tests the Optilume BPH Catheter System, a device with a drug-coated balloon that opens the prostate to improve urine flow. About 92 men aged 50 and older with moderate to severe symptoms will be treated. Researchers will check if symptoms improve and track any serious …

This study tests whether doing pelvic floor muscle exercises before and after prostate surgery can improve urinary symptoms like urgency, dribbling, and frequent urination in men with an enlarged prostate. About 46 participants will either do the exercises or receive standard car…

Acute urinary retention (AUR) is a sudden inability to urinate, often due to an enlarged prostate. The RELIEF study compares removing the catheter after 3 days versus the usual 14 days in 478 men. All participants receive a catheter and prostate medication. The goal is to see if …

This study compares a new laser procedure (TPLA) to standard surgery (TURP) for men with urinary symptoms caused by an enlarged prostate. Researchers want to see if the laser works just as well, with possibly fewer side effects. About 80 men will take part.

This early study tests whether a steam treatment guided by MRI can safely shrink an enlarged prostate and improve urinary symptoms. About 30 men with moderate-to-severe symptoms who haven't responded well to medication will receive the procedure. Researchers will measure changes …

This study tests a new care plan that lets patients go home just 24 hours after laser surgery for an enlarged prostate, instead of the usual 48 hours. Nurses will supervise recovery at home. The goal is to see if this shorter stay is safe and does not lead to more complications o…

This study looks at whether daily text message reminders to do pelvic floor exercises can help men recover bladder control faster after prostate surgery. About 132 men who are planning to have prostate surgery will be split into two groups: one gets the text reminders, the other …

This study compares two types of lasers used in prostate surgery for men with enlarged prostates (BPH). The goal is to see which laser causes less bleeding and takes less time during the operation. Fifty men who have not had prior prostate surgery will be randomly assigned to rec…

This study is gathering medical records and imaging data from 10,000 men with prostate cancer or at high risk. Researchers aim to find patterns in scans that could help diagnose and treat the disease more effectively. No new drugs or procedures are being tested.

This study compares spinal anesthesia to general anesthesia in men undergoing open simple prostatectomy for an enlarged prostate. The goal is to see if spinal anesthesia leads to less postoperative bleeding, such as fewer blood transfusions or less need for bladder irrigation. Ei…

This study compares a new formulation (AJU-G721) of a drug used for benign prostatic hyperplasia (BPH) to the original version (G721R) in healthy adult men. The goal is to see if the two versions are absorbed and processed by the body in the same way. Participants receive a singl…

This study looks at men with urinary retention who need a catheter before having prostate laser surgery (HoLEP, ThuLEP, or ThuFLEP). Researchers want to see if the length of time with a catheter affects how well the surgery works. They will measure changes in urinary symptoms, fl…

This study is creating a worldwide registry to track how well different surgical treatments work for benign prostatic hyperplasia (BPH), a condition where the prostate gland enlarges and causes urinary problems. Researchers will collect data from 7,500 participants to compare sym…

This study looks at whether watching a short educational video after HoLEP prostate surgery helps patients manage their recovery at home and reduces the need to call or visit the doctor. About 114 adults having the procedure will be randomly assigned to either watch the video or …

This study looks at whether taking dutasteride for at least 6 months before HoLEP surgery for an enlarged prostate affects bleeding, operation time, and tissue removal. Researchers will compare 1,000 men who took the drug with those who did not. The goal is to help surgeons plan …

This study looks at whether a simple ultrasound can do the same job as an MRI for measuring how well the bladder works in people with lower urinary tract symptoms (like trouble urinating). Researchers will compare results from both scans in 80 adults. If ultrasound works, it coul…

This study tests a new device designed to control bleeding after prostate surgery (TURP). The device applies steady pressure to the urethra using a catheter. Researchers will compare it to standard methods on mannequins. Sixty healthcare workers will evaluate how easy, safe, and …

This study aims to understand why some men with an enlarged prostate (BPH) do not respond to the common drug finasteride. Researchers will follow 120 men starting finasteride, tracking their symptoms and using MRI scans and genetic tests over three years. The goal is to find ways…