Benign prostatic hyperplasia

This study compares two ways of injecting BOTOX into the prostate for men with benign prostatic hyperplasia (BPH) who still have bothersome urinary symptoms despite medication. One group receives BOTOX only in the prostate gland, while the other gets injections in the prostate, b…

This study compares a new procedure called high-frequency irreversible electroporation (H-FIRE) to standard surgery (TURP) for treating benign prostatic hyperplasia (enlarged prostate). 118 men aged 40 and older with moderate to severe symptoms are participating. H-FIRE uses elec…

This study tested a closed-system bladder irrigation device designed to reduce urinary tract infections after endoscopic urologic surgery. 240 patients undergoing prostate or bladder tumor surgery were randomly assigned to use the new device or standard irrigation. The device all…

This completed study looked at medical records from over 10,000 men with enlarged prostate (BPH) in the UK and China. Researchers wanted to see if men taking 5-alpha reductase inhibitors (drugs like finasteride) had fewer heart problems like heart attacks and strokes. The study c…

This study compared two treatments for men with an enlarged prostate causing urinary symptoms. One group received a procedure called Rezum, which uses water vapor (steam) to shrink prostate tissue. The other group took a daily medication called tamsulosin. The trial enrolled 94 m…

This study looked at tiny particles called extracellular vesicles (EVs) found in prostate fluid from 100 men. The goal was to find unique molecular signatures that could help tell aggressive prostate cancer from slow-growing or benign conditions. Researchers used advanced techniq…

This study tested a simple, rapid PSA blood test that gives results in minutes, comparing it to the standard lab PSA test. Researchers enrolled 94 men with prostate cancer or benign prostate disease. The goal was to see if the quick test is accurate enough for screening. If it wo…

This completed study collected urine and blood samples from 80 men, including those with prostate cancer, suspected cancer, or benign prostate enlargement, as well as healthy donors. The goal was to find RNA biomarkers that could lead to a simple liquid biopsy test for diagnosing…

This completed study tested an artificial intelligence model called BEAM that combines MRI scans with a blood test (cell-free DNA) to improve prostate cancer diagnosis. Over 1,600 men participated, including those with healthy prostates, benign enlargement, or prostate cancer. Th…

This study looked at whether an extract from banana flower stamens could help prevent benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate that can cause urinary problems. Fifty men aged 40 to 80 with mild to moderate symptoms took part. Researchers mea…

This pilot study tests a new way to treat urinary symptoms caused by an enlarged prostate. Using 3D ultrasound guidance, doctors insert a thin needle through the skin between the scrotum and anus to deliver microwave heat directly to the overgrown prostate tissue. The approach ai…

This study compared two surgical techniques for treating benign prostatic hyperplasia (BPH): bipolar enucleation and thulium laser enucleation. Sixty men with large prostates (80 grams or more) were randomly assigned to one of the two procedures. Researchers measured operation ti…

This study tested whether a mobile app that teaches patients about prostate surgery can improve their experience. 68 patients were split into two groups: one used the app, the other received standard care. Researchers measured anxiety, fear, pain, and satisfaction before and afte…

This study compared two treatments for an enlarged prostate (BPH): a newer steam-based procedure called Rezum and a standard surgery called TUEP. Researchers measured how well each improved urinary symptoms, urine flow, and sexual function in 70 men over age 50. The goal was to s…

This study looked at 110 men with an enlarged prostate to compare two minimally invasive treatments: laser surgery (HoLEP) and water vapor therapy (Rezum). The goal was to see which one better protects sexual function, especially ejaculation. Participants filled out questionnaire…

This study tested a special type of prostate surgery designed to preserve ejaculation in men with an enlarged prostate. The surgery removes extra prostate tissue while protecting the area around the ejaculatory duct. Researchers followed 108 sexually active men for 3 months to se…

This study tested a treatment called Rezūm, which uses water vapor (steam) to shrink an enlarged prostate. It included 129 men aged 45 to 96 who had trouble urinating. The goal was to see if the treatment is safe and works well when done under local anesthesia with sedation. Resu…

This study tested whether a nerve block (injecting numbing medicine near the tailbone) can reduce pain and the need for opioid painkillers after transurethral prostate resection (TURP) surgery. Sixty men undergoing TURP were split into two groups: one received the nerve block plu…

This study followed 85 men with enlarged prostate who had a laser surgery called Thulium Fiber Laser Enucleation. The goal was to see how quickly a surgeon could learn the technique and how well it improved urinary symptoms and quality of life over a year. The results help doctor…

This study tested a special type of prostate surgery (TURP) designed to preserve the ability to ejaculate. 90 men with an enlarged prostate who had not responded to medication took part. The goal was to see if the surgery could improve urination while maintaining sexual function.

This study tested whether adding a drug called Longidaze to the standard treatment tamsulosin helps reduce urinary symptoms in men with an enlarged prostate. 229 men aged 40 and older took part. The combination was given as injections and rectal suppositories over several months,…

This study tested a special mask that uses lights and sounds to help patients relax during a prostate biopsy. The goal was to see if it reduces pain and anxiety compared to standard care. 88 men took part, and researchers measured their pain levels and satisfaction after the proc…

This study tested a drug called Tanzânia in 295 men who have both erectile dysfunction and an enlarged prostate (benign prostatic hyperplasia). The goal was to see if the drug improves erectile function better than a placebo. Participants took the drug or a dummy pill for a perio…

This study tested whether wearing a white noise sleep mask after prostate surgery (TUR-P) improves sleep quality and comfort. 70 adults who had elective surgery used the mask or standard care. The goal was to see if blocking hospital noise could help patients rest better and feel…

This study looked at 50 elderly men with an enlarged prostate who needed a urinary catheter. Doctors compared blocking blood flow to one side of the prostate versus both sides. The goal was to see if the simpler one-sided procedure could help patients stop using catheters just as…

This study tested a new device called Optilume BPH, which is a balloon coated with medicine that is inflated inside the prostate to open the urinary passage. The goal was to see if it safely improves moderate-to-severe urinary symptoms in men with an enlarged prostate. Eighty men…

This study tested a 3D imaging navigation system to help guide HoLEP surgery for benign prostate enlargement. 150 men were split into two groups: one with the navigation system and one without. The goal was to see if the system reduces complications like urine leakage and urethra…

This study tested whether listening to relaxing instrumental music during prostate surgery helps reduce anxiety and pain afterward. 135 men having a specific type of prostate surgery were randomly assigned to either listen to music or receive standard care. Researchers measured a…

This study tested a special laser to treat an enlarged prostate (BPH) in 20 men who needed surgery. The laser was used to vaporize extra prostate tissue, and the men were followed for 3 months to see how well it worked and if there were side effects. The goal was to find out if t…

This completed Phase I safety trial tested whether using the UroLift system—a device that lifts and holds enlarged prostate tissue out of the way—before stereotactic ablative body radiotherapy (SABR) is safe for men with both prostate cancer and benign prostatic hyperplasia (BPH)…

This study tested a new, less invasive laser treatment (TU-FLAP) against standard surgery (TURP) for men with an enlarged prostate causing bothersome symptoms. 56 men were randomly assigned to one of the two procedures and monitored for a year. The goal was to see if the new lase…

This study tested two drugs used to reverse muscle relaxants after surgery: sugammadex and a combination of neostigmine and glycopyrrolate. The goal was to see which one better prevents urinary retention in 124 patients having ear, nose, or throat surgery who were at high risk du…

This study compared penile length in 200 adult men undergoing cystoscopy under spinal anesthesia versus general anesthesia. Researchers measured length and asked surgeons to rate satisfaction with access. The goal was to see if anesthesia choice affects penile size during the pro…

This study looked at 120 men who had HoLEP surgery for an enlarged prostate. Researchers wanted to see if bowel problems before surgery made recovery harder. Patients filled out questionnaires about bowel and urinary symptoms before and after surgery. The goal was to learn how bo…

This study looked at 30 men taking alpha-blocker drugs for urinary symptoms who were scheduled for cataract surgery. Researchers used a special eye scan to measure the thickness of iris muscles and pupil size. The goal was to see if these measurements could predict intraoperative…

This study looked at 132 men aged 55-80 who had surgery for an enlarged prostate. Researchers compared two common procedures—HoLEP and TURP—to see if one affects memory and thinking more than the other. Participants took thinking tests before surgery and three months after. The g…

This early-stage study tested a new drug called CKD-846 in 31 healthy men to see how the body processes it and if it is safe. The goal was to gather information, not to treat the condition. Participants were healthy men aged 19 to 55 who agreed to use contraception.

This study looked at 130 men aged 50+ with enlarged prostate (BPH) causing urinary symptoms. Researchers used an ultrasound to measure how far the prostate bulges into the bladder, then tracked symptom changes over 6 months of standard medication. The goal was to see if this simp…

This study looked at 12 men with benign enlarged prostate who had Greenlight laser surgery. Researchers used MRI and special ultrasound scans to measure the area of dead tissue created by the laser and tracked urinary symptoms for a year. The goal was to better understand how the…

This study looked at whether a simple smiley-face tool (HappyOrNot) or a visual scale (VAS) can effectively measure urinary symptoms in men with an enlarged prostate. One hundred men from two hospitals filled out these quick tests, and the results were compared to standard sympto…

This study tested a new classification system called BICEP to better identify and categorize bladder injuries that can happen during prostate surgery. Researchers studied 250 patients undergoing common prostate procedures to see how often injuries occur and how severe they are. T…

This study followed 30 men aged 45-70 who had their prostate removed due to cancer. Researchers measured urine leakage by weighing pads over 24 hours and during a 1-hour activity test. The goal was to better understand how long and how severe incontinence lasts after surgery.

This completed registry study collected real-world data on 99 patients receiving HydroPearl microspheres to block blood flow to conditions like uterine fibroids, arteriovenous malformations, hypervascular tumors, and benign prostatic hyperplasia. The procedure was done through th…

This study gave 20 men with enlarged prostates a single dose of the antibiotic ertapenem before their scheduled prostate surgery. Researchers then measured how much of the drug actually reached the prostate tissue. The goal was to see if a pre-surgery dose could provide enough an…