Benign prostatic hyperplasia

This study tests whether using MRI and AI to guide steam therapy can improve treatment for an enlarged prostate (BPH). Men aged 30-80 with moderate symptoms and a prostate size between 30-80 mL are eligible. All participants receive the standard steam procedure, but with added MR…

This early-stage trial will compare a new drug called AJU-G721 to an existing reference drug, G721R, in 36 healthy adult men. The goal is to see if the two drugs produce similar levels in the blood and have comparable safety. Both drugs contain tamsulosin, which is used to treat …

This study follows 600 men in South Korea with moderate to severe enlarged prostate symptoms that tamsulosin alone didn't control well. Researchers will track side effects and symptom improvement over 24 weeks of treatment with Vesomni, a combination tablet. The goal is to see ho…

This study tests a new device that uses pulsed energy to shrink the prostate in men with bothersome urinary symptoms from an enlarged prostate (BPH). About 250 men over age 45 will either get the new treatment or a standard scope procedure. The goal is to see if the new device sa…

This study compares two minimally invasive procedures for men with an enlarged prostate that has a median lobe—a part that can block urine flow. One treatment uses water vapor (steam) to shrink tissue, the other uses a laser. Eighty men will be randomly assigned to one of the two…

This study tests a new procedure called H-FIRE for men with an enlarged prostate (BPH). Instead of using heat like standard surgeries, H-FIRE uses short electrical pulses to destroy blocking tissue while sparing nerves and muscles. The trial will enroll 288 men aged 50 and older,…

This study compares two ways to drain urine in men with blocked bladders before prostate surgery: self-catheterization (done by the patient several times a day) versus a permanent tube. The goal is to see if self-catheterization leads to fewer infections. About 106 men over 50 wi…

This study tests a new approach called Bioblation, which combines a prostate biopsy with laser ablation in a single session under local anesthesia. It is for men with severe urinary symptoms and suspected low- to intermediate-risk prostate cancer. The goal is to see if this one-s…

This study tests whether giving tranexamic acid (a drug that helps blood clot) before prostate surgery can reduce bleeding and prevent anemia in older men. About 80 men aged 50+ with enlarged prostates will receive either the drug or a placebo. The goal is to see if this simple a…

This study tests a liquid material called SQUIDPERI for a procedure that blocks blood flow to the prostate (prostatic artery embolization) in men with an enlarged prostate. The goal is to see if it works better than standard particles at easing urinary symptoms like frequent or w…

This study tests whether taking antibiotics for 3 days before prostate surgery works as well as the usual 7 days to prevent infections like urinary tract infections or sepsis. The trial includes 250 adults who have a urinary catheter and are scheduled for a specific prostate proc…

This study tests a new, non-invasive wearable device that uses electrical impedance tomography to monitor bladder function in 40 men with benign prostatic hyperplasia (BPH). Participants will wear the device while undergoing standard urine flow tests to see if the new method matc…

This study is developing a new blood test that combines quantum sensors and artificial intelligence to detect prostate cancer. Researchers will analyze DNA fragments in blood samples from 1100 men to train an AI model. The goal is to create a non-invasive, accurate diagnostic too…

This study will compare two treatments for moderate to severe urinary symptoms caused by an enlarged prostate. One group takes a standard drug (alfalitic) plus a natural supplement (Serenoa repens, or saw palmetto), while the other takes the same drug plus another standard medica…

This study tests a laser surgery for men with small prostates that still cause bothersome urinary symptoms. It compares three surgical methods to see which best prevents bladder neck scarring and improves urine flow. 426 men aged 40 to 80 will take part. The goal is to find the s…

This study tests a procedure called irreversible electroporation (IRE) to treat urinary symptoms caused by an enlarged prostate. About 40 men aged 50 and older with moderate to severe symptoms will receive the treatment. The goal is to see if IRE safely improves urine flow and re…

This study looks at whether the Emsella chair, a non-invasive device that strengthens pelvic floor muscles, can reduce short-term stress urinary incontinence in men after prostate surgery for an enlarged prostate. Thirty men with moderate-to-large prostates will receive Emsella t…

This study tests whether guided imagery exercises can reduce fear and improve comfort in men undergoing a common prostate surgery (TURP). Seventy participants will be randomly assigned to either listen to guided imagery sessions before and after surgery or receive standard care a…

This study tests whether a 12-week program of pelvic floor exercises, extra health information, and mental health support before prostate surgery can help men recover faster and reduce short-term urine leakage. Forty men with enlarged prostates will be split into two groups: one …

This study tracks how well the Zenflow Spring System works in everyday medical practice for men with BPH (enlarged prostate). About 300 participants will be followed for a year to see if symptoms improve, how quickly they return to normal activities, and if any side effects occur…

This study tests whether high-intensity focused ultrasound (HIFU) can safely and effectively treat urinary symptoms caused by an enlarged prostate. Seventeen men aged 45 to 80 with moderate to severe symptoms will receive a single HIFU treatment using a probe placed in the rectum…

This study compares two common drugs, silodosin and tamsulosin, to see which one better relieves moderate to severe urinary symptoms caused by an enlarged prostate. About 140 men aged 50 and older will take each medication for four weeks in a crossover design, with no washout per…

This study tests whether taking a daily 5 mg tadalafil pill can help men with an enlarged prostate recover bladder control faster after surgery. About 40 men will receive either tadalafil or a placebo for 12 weeks after their procedure. The goal is to see if the drug reduces stre…

This study tests a gel called PuraStat that is applied inside the prostate after a water-jet surgery (Aquablation) for enlarged prostate. The goal is to see if it reduces bleeding enough for men to go home the same day. Twenty-five men will take part in this early pilot study.

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This study compares three different surgical techniques for men with enlarged prostates (over 80 grams) who have trouble urinating. The goal is to see which method is safest and works best in the short term. About 105 men will take part and be followed for at least one year after…

This study compares three different laser types used during prostate surgery for men with an enlarged prostate (BPH). The goal is to see which laser removes prostate tissue most efficiently and safely. About 159 men aged 50 to 80 who need surgery will take part. Results will help…

This study will compare two laser surgeries (HoLEP and ThuLEP) for treating an enlarged prostate in 200 men aged 40-90. The goal is to see which procedure better preserves bladder control, avoids urethral narrowing, and maintains sexual function. Researchers will track outcomes l…

This study compares taking tamsulosin every day versus every other day in 288 men aged 40 and older with enlarged prostate and moderate-to-severe urinary symptoms. The goal is to see if the every-other-day schedule controls symptoms just as well while possibly causing fewer sexua…

This study tests a new medicine, DNN.65.21.005, against a standard drug (Combodart) to see if it safely reduces urinary problems caused by an enlarged prostate. About 218 men aged 50 and older with bothersome symptoms will take the drug for 180 days. The main goal is to measure c…

This study compares three common surgeries for an enlarged prostate (BPH) in about 200 men. The goal is to see which procedure works best for improving urination, quality of life, and sexual function. Results will help doctors guide patients to the most suitable treatment.

This study tests Prosman™, a supplement made from plum extract, in 38 men aged 40-60 with mild to moderate prostate enlargement symptoms. Participants will take either Prosman™ or a placebo daily for 8 weeks. Researchers will measure changes in urinary symptoms, hormone levels, a…

This study looks at men with an enlarged prostate who previously used the ProVee urethral expander device. Researchers want to see if these men needed any additional surgical treatments after the device was removed. The goal is to understand how well the device works over the lon…

This study looks at how feeling anxious or scared before prostate surgery affects recovery and satisfaction in men with an enlarged prostate. Researchers will follow 80 men who are having either laser or standard surgery. They will use questionnaires to measure anxiety, depressio…

This study will analyze data from 2,000 men who had prostate surgery for an enlarged prostate (BPH). Researchers want to build a scoring system using MRI scans, urine flow tests, and symptom scores to predict who will have a good outcome. The goal is to help doctors and patients …

This study looks at men over 50 with an enlarged prostate who cannot empty their bladder and need a catheter. They will all have a standard surgery called TURP to remove part of the prostate. Researchers want to see if those with weak bladder muscles (detrusor underactivity) are …

This study will follow 400 men undergoing HoLEP surgery for an enlarged prostate to see if the percentage of tissue removed (enucleation ratio) predicts how much their symptoms improve after 3 months. Researchers aim to find the minimum ratio needed for meaningful relief, measure…

This study will look at 320 men having HoLEP surgery for an enlarged prostate to see if the type of anesthesia (general vs. spinal) affects bleeding and recovery. Researchers will measure changes in hemoglobin levels, time to discharge, and symptom scores three months after surge…

This study will test a special AI program called UroMed AI Doctor, designed to help with urology care. Researchers will compare AI-assisted care to traditional care from a specialist for patients with kidney stones, enlarged prostate, or bladder cancer. The goal is to see if the …

This registry will follow 3,000 men with benign prostatic hyperplasia (BPH) who undergo Aquablation, a waterjet-based procedure to remove excess prostate tissue. Researchers will collect data from medical records to evaluate how well the procedure improves urinary symptoms and it…

This study is a large registry that will follow 2,000 men with enlarged prostate (BPH) who receive minimally invasive treatments like Rezum, UroLift, or Aquablation. Researchers will track symptoms, urine flow, and quality of life for up to 6 years to see which treatments work be…

This study aims to find out what factors help predict a successful outcome after a type of prostate surgery called HoLEP, which treats an enlarged prostate. Researchers will follow 604 men aged 40 and older who are scheduled for HoLEP. They will measure success based on symptom r…

This study looks at whether a protein called CTGF in urine can indicate bladder scarring and predict how well men recover after surgery for an enlarged prostate. Researchers will measure CTGF levels before surgery in 50 men and compare them to their outcomes. The goal is to find …

This early-stage trial tests a new drug called CKD-846 in 32 healthy men with benign prostate hypertrophy (enlarged prostate). The main goal is to see how the drug moves through the body and if it is safe. Participants must be men aged 19 to 55 with a healthy weight.

This study looks at how age and sex influence pain before and after a first-time flexible cystoscopy (a thin tube inserted into the bladder). Researchers will ask 150 adults to rate their expected and actual pain using a simple 0-10 scale. The goal is to better understand who mig…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study will observe 200 men with an enlarged prostate (BPH) who are scheduled for a standard surgery called TURP. Researchers want to find out which simple tests done before surgery—like symptom questionnaires, ultrasound, and urine flow measurements—best predict a good outco…

This early-stage study tests two different forms of a drug for benign prostatic hyperplasia (enlarged prostate) in 44 healthy adult male volunteers. Participants receive a single dose of each version under fasting conditions to compare safety and how the drug moves through the bo…

This study will check if a new measure, the Qmax/eGFR ratio, is linked to how severe urinary symptoms are in men over 40. Qmax measures urine flow speed, and eGFR reflects kidney function. One hundred men with urinary issues will take a urine flow test, a blood test, and a sympto…

This study will observe 100 men aged 40 and older who have lower urinary tract symptoms (like frequent or weak urination). Researchers will ask them if they would consider surgery if their symptoms don't improve. They will also measure symptom severity and urine flow. The goal is…

This study will enroll 250 men aged 40 and older who have lower urinary tract symptoms. Researchers will compare different urine flow patterns (measured by a simple test) with symptom scores from a standard questionnaire. The goal is to see if certain flow patterns are linked to …