New Needle-Free prostate treatment could replace surgery

NCT ID NCT05306145

Completed Disease control Sponsor: Shanghai East Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a new procedure called high-frequency irreversible electroporation (H-FIRE) to standard surgery (TURP) for treating benign prostatic hyperplasia (enlarged prostate). 118 men aged 40 and older with moderate to severe symptoms are participating. H-FIRE uses electrical pulses to destroy excess prostate tissue without cutting, while TURP surgically removes tissue. The goal is to see if H-FIRE is as effective at improving urine flow and symptoms, with potentially fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: High frequency irreversible electroporation (H-FIRE) procedure
What this could lead to: If H-FIRE works as well as TURP but with fewer side effects, it could offer men with enlarged prostate a less invasive treatment option.
What could go wrong: This is a small, single-center trial with 118 participants, so results may not apply to everyone. H-FIRE is still experimental and may not be as effective or safe as standard surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

benign prostatic hyperplasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BENIGN PROSTATIC HYPERPLASIA

Contacts and locations

Locations

Haifeng Wang

Shanghai, China

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