BENIGN PROSTATIC HYPERPLASIA

This trial tests a new device called Vivifi that aims to reduce symptoms of an enlarged prostate (BPH) by gently altering the blood supply to the prostate through a small scrotal procedure. The study involves 20 men aged 45–80 with moderate-to-severe urinary symptoms. Researchers…

This trial compares two prostate medications, tamsulosin and silodosin, to see how each affects the iris—the colored part of the eye—in men with benign prostatic hyperplasia (BPH). Both drugs can make the iris floppy and the pupil small, which complicates cataract surgery. The st…

This trial is testing whether a new formulation of a drug for benign prostatic hyperplasia (enlarged prostate) works the same as the existing version. Healthy adult male volunteers receive a single dose of each formulation after a meal, and researchers compare how much drug gets …

This trial compares a new formulation (AD-116A) of a drug used for benign prostatic hyperplasia to the original version (AD-1161) in healthy adult male volunteers. The goal is to see if the two formulations are bioequivalent—meaning they work the same way in the body. Participant…

This study follows 600 men in South Korea with moderate to severe enlarged prostate symptoms that tamsulosin alone didn't control well. Researchers will track side effects and symptom improvement over 24 weeks of treatment with Vesomni, a combination tablet. The goal is to see ho…

This study compares two minimally invasive procedures for men with an enlarged prostate that has a median lobe—a part that can block urine flow. One treatment uses water vapor (steam) to shrink tissue, the other uses a laser. Eighty men will be randomly assigned to one of the two…

This study tests a new approach called Bioblation, which combines a prostate biopsy with laser ablation in a single session under local anesthesia. It is for men with severe urinary symptoms and suspected low- to intermediate-risk prostate cancer. The goal is to see if this one-s…

This study tests whether giving tranexamic acid (a drug that helps blood clot) before prostate surgery can reduce bleeding and prevent anemia in older men. About 80 men aged 50+ with enlarged prostates will receive either the drug or a placebo. The goal is to see if this simple a…

This study tests a new, non-invasive wearable device that uses electrical impedance tomography to monitor bladder function in 40 men with benign prostatic hyperplasia (BPH). Participants will wear the device while undergoing standard urine flow tests to see if the new method matc…

This trial investigates whether early electroacupuncture can reduce persistent lower urinary tract symptoms—like frequent or painful urination—in men recovering from benign prostatic hyperplasia surgery. Participants receive three sessions of electroacupuncture starting two days …

This trial tests whether coloring mandalas for 20 minutes can lower anxiety, pain, and improve vital signs and satisfaction in men undergoing transurethral resection of the prostate (TURP). Half of the 64 participants will color a mandala before surgery; the other half will recei…

This study tests a laser surgery for men with small prostates that still cause bothersome urinary symptoms. It compares three surgical methods to see which best prevents bladder neck scarring and improves urine flow. 426 men aged 40 to 80 will take part. The goal is to find the s…

This study looks at whether the Emsella chair, a non-invasive device that strengthens pelvic floor muscles, can reduce short-term stress urinary incontinence in men after prostate surgery for an enlarged prostate. Thirty men with moderate-to-large prostates will receive Emsella t…

This study tests whether guided imagery exercises can reduce fear and improve comfort in men undergoing a common prostate surgery (TURP). Seventy participants will be randomly assigned to either listen to guided imagery sessions before and after surgery or receive standard care a…

This study tests whether a 12-week program of pelvic floor exercises, extra health information, and mental health support before prostate surgery can help men recover faster and reduce short-term urine leakage. Forty men with enlarged prostates will be split into two groups: one …

This study compares two common drugs, silodosin and tamsulosin, to see which one better relieves moderate to severe urinary symptoms caused by an enlarged prostate. About 140 men aged 50 and older will take each medication for four weeks in a crossover design, with no washout per…

This study tests a gel called PuraStat that is applied inside the prostate after a water-jet surgery (Aquablation) for enlarged prostate. The goal is to see if it reduces bleeding enough for men to go home the same day. Twenty-five men will take part in this early pilot study.

This study tests Prosman™, a supplement made from plum extract, in 38 men aged 40-60 with mild to moderate prostate enlargement symptoms. Participants will take either Prosman™ or a placebo daily for 8 weeks. Researchers will measure changes in urinary symptoms, hormone levels, a…

This study compares two common prostate medications, tamsulosin and silodosin, to see how they affect pupil size and the thickness of a layer at the back of the eye called the choroid. Men aged 50 and older with benign prostatic hyperplasia (BPH) who have not used these drugs bef…

This study follows men aged 45 and older who are scheduled for surgery that removes only the middle part of an enlarged prostate (the median lobe). The goal is to see which factors before surgery—like symptoms, urine flow, and prostate shape—are linked to success one year later. …

This study examines how often patients have a difficult time placing a breathing tube during prostate surgery called HoLEP. Researchers look back at medical records of 300 patients to find out which factors, such as weight, prostate size, or certain medications, may increase the …

This study looks at how feeling anxious or scared before prostate surgery affects recovery and satisfaction in men with an enlarged prostate. Researchers will follow 80 men who are having either laser or standard surgery. They will use questionnaires to measure anxiety, depressio…

This study will analyze data from 2,000 men who had prostate surgery for an enlarged prostate (BPH). Researchers want to build a scoring system using MRI scans, urine flow tests, and symptom scores to predict who will have a good outcome. The goal is to help doctors and patients …

This study looks at men over 50 with an enlarged prostate who cannot empty their bladder and need a catheter. They will all have a standard surgery called TURP to remove part of the prostate. Researchers want to see if those with weak bladder muscles (detrusor underactivity) are …

This study looks at whether a protein called CTGF in urine can indicate bladder scarring and predict how well men recover after surgery for an enlarged prostate. Researchers will measure CTGF levels before surgery in 50 men and compare them to their outcomes. The goal is to find …

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…