BENIGN PROSTATIC HYPERPLASIA

This early-stage study compares two versions of an experimental drug (AD-116 and AD-1161) for benign prostatic hyperplasia (enlarged prostate). It involves 44 healthy adult men who receive a single dose of each version under fed conditions to check safety and how the drug moves t…

This study tests a device that sends mild electrical pulses to the sacral nerve to help men with overactive bladder. It aims to reduce urgent bathroom trips and improve quality of life. About 150 men will be followed for one year to check safety and effectiveness.

This study tests the safety of a new device that uses sound waves (histotripsy) to break down extra prostate tissue in men with benign prostatic hyperplasia (BPH). About 80 men aged 50 and older with moderate to severe symptoms will be treated and monitored for side effects. The …

This study is testing a new robotic system to help surgeons remove excess prostate tissue in men with an enlarged prostate (BPH). About 54 men will take part to see if the robot can complete the surgery without needing to switch to standard methods. The goal is to improve precisi…

This study is testing a new device called the Glean Urodynamics System that monitors bladder function both in the clinic and at home for up to 24 hours. About 101 adults with bladder problems like overactive bladder or enlarged prostate will use the device to see if it is safe an…

This study is tracking 500 men who receive the Optilume BPH Catheter System to treat symptoms of an enlarged prostate (BPH). The goal is to see how well the device improves urinary symptoms and how safe it is in everyday use. Participants are followed for 12 months to measure cha…

This study tests whether pelvic floor muscle exercises can help men who have had prostate surgery for an enlarged prostate (BPH) regain better bladder control and improve their quality of life. About 46 participants will be randomly assigned to either do these exercises or receiv…

This study tests whether adding a traditional Chinese medicine called Lingze tablets to the standard drug tamsulosin can improve sleep and reduce nighttime urination in men who still have bothersome symptoms after prostate surgery. About 136 men aged 50 and older will be randomly…

This study tests a modified surgery that aims to keep ejaculation working while still treating urinary problems from an enlarged prostate. About 336 men over 40 will be randomly assigned to either the standard complete removal or a partial removal that spares the area needed for …

This study tests the Optilume BPH Catheter System in 92 men aged 50 and older with an enlarged prostate causing urinary problems. The goal is to see if the device safely improves symptoms like frequent urination and weak stream. Participants will be followed for 12 months to meas…

This study tests a special catheter that delivers numbing medicine directly into the prostate during Rezum water vapor therapy for enlarged prostate. The goal is to see if this local anesthesia can replace general anesthesia, making the procedure faster and less painful. About 24…

This study is a worldwide registry that will collect information from 7500 men undergoing surgery for an enlarged prostate (BPH). The goal is to track how well different surgical treatments work in real life and what complications occur. By gathering this data, doctors hope to be…

This study is for men aged 50 and older with an enlarged prostate who are starting finasteride. Researchers want to learn why some men don't get symptom relief from this drug. They will use MRI scans and symptom questionnaires to find markers that could predict resistance, so fut…

This study looks at whether men with an enlarged prostate can safely continue taking their blood thinners during laser surgery. About 389 men on anticoagulants will be randomly assigned to either stay on their medication or stop it before surgery. The goal is to see if continuing…