Shockwave combo may improve penile curvature treatment
NCT ID NCT06065436
First seen Jan 08, 2026 · Last updated Jun 22, 2026 · Updated 33 times
Summary
This Mayo Clinic study tests whether adding low-intensity shockwave therapy to Xiaflex injections can further reduce penile curvature in men with Peyronie's disease. Sixty men with stable symptoms and curvature between 30 and 90 degrees will receive both treatments. The goal is to see if the combination improves bother, sexual function, and the need for surgery.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic Minnesota
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Collagenase Clostridium Histolyticum (Xiaflex) and low-intensity shockwave therapy
What this could lead to
If it works, this combination could offer a non-surgical way to better straighten the penis and improve sexual function for men with Peyronie's disease.
What could go wrong
This is a small, early-phase trial with only 60 participants. The shockwave therapy may not add any benefit over Xiaflex alone, and results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.