Shockwave combo may boost penile curvature treatment

NCT ID NCT06065436

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding low-intensity shockwave therapy to standard Xiaflex injections can better reduce penile curvature in men with Peyronie's disease. Sixty participants will receive both treatments or Xiaflex alone. The goal is to improve sexual function and reduce bother from symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Collagenase Clostridium Histolyticum (Xiaflex) and low-intensity shockwave therapy
What this could lead to: If it works, this could offer a more effective non-surgical option to reduce penile curvature and improve sexual function in men with Peyronie's disease.
What could go wrong: This is a small, early-phase trial with only 60 participants. The shockwave therapy may not add significant benefit, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

erectile dysfunction Penile Induration Peyronie disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ERECTILE DYSFUNCTION PEYRONIE DISEASE

Contacts and locations

Locations

Mayo Clinic Minnesota
RECRUITING

Rochester, Minnesota, 55905, United States

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