Can a daily pill rescue erectile function when On-Demand treatments fail?

NCT ID NCT07753720

Recruiting now Disease control Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 14, 2026 · Updated 5 times

Summary

This trial compares two approaches for men with erectile dysfunction that doesn't respond well to on-demand PDE5 inhibitor pills: taking a low-dose tadalafil pill every day on its own, or taking it alongside the usual on-demand medication. Over 12 weeks, researchers will measure changes in erectile function, treatment satisfaction, and side effects in 260 men aged 18 to 70. The goal is to see whether the daily-plus-on-demand combination offers better results than daily tadalafil alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tadalafil 5 mg taken daily, either alone or added to the participant's current on-demand PDE5 inhibitor
What this could lead to: If adding daily tadalafil works better than the on-demand pill alone, it could offer a new option for men whose erectile dysfunction doesn't improve with standard on-demand treatments.
What could go wrong: This is a relatively small, 12-week trial, and results may not apply to everyone. Tadalafil can cause side effects like headache, flushing, or upset stomach, and the added benefit over monotherapy is not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ERECTILE DYSFUNCTION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

erectile dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ERECTILE DYSFUNCTION TADALAFIL

Contacts and locations

Locations

Department of Urology, Al-Hussein and Sayed Galal University Hospitals, Al-Azhar University
RECRUITING

Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.