Natural supplement vs. little blue pill: which works better for ED?

NCT ID NCT07642505

Recruiting now Symptom relief Sponsor: Beni-Suef University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a natural supplement called L-citrulline can improve mild to moderate erectile dysfunction as well as the standard drug tadalafil (Cialis), and whether taking both together works even better. About 133 men aged 30-70 will take one of three treatments daily for 12 weeks. Researchers will measure changes in erectile function scores and track side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: L-citrulline and tadalafil
What this could lead to: If it works, this could show that a natural supplement (L-citrulline) is as effective as a standard ED drug, or that combining them works better than either alone.
What could go wrong: This is a small, early-phase trial (133 men) comparing a supplement to an established drug. The supplement may not work as well, and results may not apply to all men with ED.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

erectile dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ERECTILE DYSFUNCTION

Contacts and locations

Locations

Department of Urology- Beni-Suef University Hospitals
RECRUITING

Banī Suwayf, Beni Suweif Governorate, 02456, Egypt

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